METHODS OF DIAGNOSING AND TREATING MICROBIOME-ASSOCIATED DISEASE USING INTERACTION NETWORK PARAMETERS
First Claim
1. A method for modulating microbiota comprising(i) analyzing a biological interaction network within a superorganism which includes at least one microbial derived component, wherein a superorganism is an organism consisting of many organisms, and wherein a microbial derived component is a microbe, or a gene, protein, transcript, carbohydrate, lipid, or metabolite derived from a microbe,(ii) selecting a node or edge in the network, wherein a node is a terminal point or an intersection point of a graphical representation of a network;
- and wherein an edge is a link between two nodes, and(iii) providing modulators of the node or edge.
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Accused Products
Abstract
Methods of diagnosing and treating microbiome-associated disease or improving health using interaction network parameters are provided. Methods are provided to analyze interaction networks between microbes, and between microbes and the host, to determine important (e.g. “highly-connected”) organisms or molecules as determined by various network parameters. Methods are provided including and beyond correlation to use these “highly-connected” organisms or molecules as targets for modulation or as therapeutic agents to improve health.
152 Citations
11 Claims
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1. A method for modulating microbiota comprising
(i) analyzing a biological interaction network within a superorganism which includes at least one microbial derived component, wherein a superorganism is an organism consisting of many organisms, and wherein a microbial derived component is a microbe, or a gene, protein, transcript, carbohydrate, lipid, or metabolite derived from a microbe, (ii) selecting a node or edge in the network, wherein a node is a terminal point or an intersection point of a graphical representation of a network; - and wherein an edge is a link between two nodes, and
(iii) providing modulators of the node or edge. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
- and wherein an edge is a link between two nodes, and
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10. A method for developing diagnostics for the determination of a physiological state comprising
(i) analyzing a biological interaction network within a superorganism which includes at least one microbial derived component, (ii) selecting a node or edge in the network based on one or more network parameters, and (iii) developing a diagnostic to measure the node.
Specification