SAMPLE ANALYSIS SYSTEM
First Claim
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1. A disposable reaction cassette for a sample analysis device, comprising:
- a plurality of containers, each having an open top end and a closed bottom end, wherein at least one of said plurality of containers is pre-packaged with a reagent needed for a sample analysis procedure and is sealed with a pierceable or removable cover at the top end of said container; and
a flow strip comprising;
a plurality of ports; and
one or more reaction chambers connected to one or more of said plurality of ports, each reaction chamber comprises a microarray,wherein said plurality of ports interact with said sample analysis device via one or more fluid communication devices to establish fluid communication between said plurality of ports and said sample analysis device.
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Abstract
An integrated sample analysis system is disclosed. The sample analysis system contains (1) a sample preparation/analysis module having sample purification device comprising a monolith that binds specifically to nucleic acids and a sample analysis device comprising a microarray enclosed in a reaction chamber having a hydrophilic interior surface; (2) a temperature control module comprising a thermocycler having a thermally conductive temperature-control bladder; and (3) an imaging device capable of capturing an image of the microarray in the reaction chamber.
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Citations
20 Claims
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1. A disposable reaction cassette for a sample analysis device, comprising:
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a plurality of containers, each having an open top end and a closed bottom end, wherein at least one of said plurality of containers is pre-packaged with a reagent needed for a sample analysis procedure and is sealed with a pierceable or removable cover at the top end of said container; and a flow strip comprising; a plurality of ports; and one or more reaction chambers connected to one or more of said plurality of ports, each reaction chamber comprises a microarray, wherein said plurality of ports interact with said sample analysis device via one or more fluid communication devices to establish fluid communication between said plurality of ports and said sample analysis device. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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15. A flow strip comprising:
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a plurality of ports, each port comprises a pierceable septum or a dome valve for establishing fluid communication with a sample purification device; and a plurality of reaction chambers, connected to said plurality of ports, wherein each reaction chamber contains a microarray. - View Dependent Claims (16)
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17. A flow control manifold, comprising:
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a manifold body; a plurality of fluid supply ports formed on said manifold body, said fluid supply ports are adapted to be connected to a fluid supply device; a plurality of plunger channels formed within said manifold body, wherein each plunger channel having a plunger channel inlet at one end and a plunger channel outlet at another end; and a plurality of plungers that are movable along the length of said plunger channels, wherein each plunger comprises a seal that seals against the interior wall of the plunger channel in which said plunger is located and wherein said plungers enter said plunger channels from said plunger channel inlets, wherein each of said plurality of fluid supply ports is connected to a plunger channel at a location in the proximity of the plunger channel inlet of said plunger channel. - View Dependent Claims (18)
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19. A flow-control device, comprising:
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a selector channel having a plurality of outlet ports, and a linear motion actuator comprising; an elongated shaft; and a motor that controls the linear movement of said shaft, wherein said elongated shaft having a proximal end, a distal end, and an enclosed fluid communication channel within said shaft, said fluid communication channel extends from a first opening at said proximal end of said shaft to a second opening at said distal end of said shaft, said first opening is adapted to be connected to a fluid source, and said second opening is flanked by two seals on said shaft such that when said shaft is placed in said selector channel, said two seals seal against the interior wall of said selector channel and form a fluid communication passage between said two seals, wherein a fluid communication is established between said fluid source and an outlet port of said flow-control device when said fluid communication passage is formed between said second opening and said outlet port.
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20. An integrated sample analysis system, comprising:
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(1) a sample preparation/analysis module comprising; a sample purification device comprising a monolith that binds specifically to nucleic acids; and a sample analysis device comprising a microarray enclosed in a reaction chamber having a hydrophilic interior surface; (2) a temperature control module comprising; a thermocycler comprising a thermally conductive temperature-control bladder, said bladder being configured such that, upon receiving said temperature-control substance, said bladder expands to abut an exterior surface of said reaction chamber to enable thermal exchange between said temperature-control substance and the internal volume of said reaction chamber; and (3) an imaging device positioned to capture an image of said microarray in said reaction chamber.
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Specification