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BISPECIFIC ANTI-EGFR/ANTI-IGF-1R ANTIBODIES

  • US 20120149879A1
  • Filed: 12/20/2011
  • Published: 06/14/2012
  • Est. Priority Date: 09/26/2008
  • Status: Abandoned Application
First Claim
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1. A bispecific antibody binding to EGFR and IGF-1R comprising a first antigen-binding site that binds to EGFR and a second antigen-binding site that binds to IGF-1R, characterized in thati) said antigen-binding sites are each a pair of an antibody heavy chain variable domain and an antibody light chain variable domain;

  • ii) said first antigen-binding site comprises in the heavy chain variable domain a CDR3 region of SEQ ID NO;

    1, a CDR2 region of SEQ ID NO;

    2, and a CDR1 region of SEQ ID NO;

    3, and in the light chain variable domain a CDR3 region of SEQ ID NO;

    4, a CDR2 region of SEQ ID NO;

    5, and a CDR1 region of SEQ ID NO;

    6; and

    iii) said second antigen-binding site comprises in the heavy chain variable domain a CDR3 region of SEQ ID NO;

    11, a CDR2 region of SEQ ID NO;

    12, and a CDR1 region of SEQ ID NO;

    13, and in the light chain variable domain a CDR3 region of SEQ ID NO;

    14, a CDR2 region of SEQ ID NO;

    15, and a CDR1 region of SEQ ID NO;

    16;

    or said second antigen-binding site comprises in the heavy chain variable domain a CDR3 region of SEQ ID NO;

    17, a CDR2 region of SEQ ID NO;

    18, and a CDR1 region of SEQ ID NO;

    19, and in the light chain variable domain a CDR3 region of SEQ ID NO;

    20, a CDR2 region of SEQ ID NO;

    21, and a CDR1 region of SEQ ID NO;

    22.

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