Crosslinked Adduct of Polyaniline and Polymer Acid Containing Redox Enzyme for Electrochemical Sensor
1 Assignment
0 Petitions
Accused Products
Abstract
A polymer matrix that may coated on an electrode is created by co-crosslinking (1) an adduct of a polyaniline formed by templated oxidative polymerization on a polymer acid; (2) a water-soluble crosslinker; and (3) a redox enzyme. The polymer matrix may be hydrated, and the absorbed water may make it permeable to, for example, glucose. The polyaniline may be polyaniline itself or a substituted polyaniline; the water-soluble crosslinker may be poly(ethylene glycol)diglycidyl ether, and the redox enzyme may be glucose oxidase. The polymer matrix may be produced by co-crosslinking (1) an adduct of an electrically conductive polymer and a polymer acid; (2) a water-soluble crosslinker; and (3) a redox enzyme in a single step at an about neutral pH, curing by drying. After hydration, the crosslinked polymer matrix may form a 3-dimensional glucose-permeable bioelectrocatalyst, catalyzing the electrooxidation of glucose.
-
Citations
34 Claims
-
1-21. -21. (canceled)
-
22. A method of determining the concentration of an analyte in a biological fluid, the method comprising:
-
contacting an electrochemical sensor with the biological fluid, wherein the electrochemical sensor comprises; a working electrode; a counter electrode; and a crosslinked polymer matrix disposed on a least a portion of the working electrode, the crosslinked polymer matrix comprising; polyaniline or a ring substituted polyaniline and a polymer acid; a water soluble crosslinker; and one or more enzymes, wherein at least one of the enzymes is a redox enzyme; and determining the concentration of the analyte in the biological fluid. - View Dependent Claims (23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34)
-
Specification