COMPOSITION FOR INDUCING MIGRATION OF NEURAL STEM CELLS CONTAINING PERIOSTIN AS EFFECTIVE INGREDIENT

• US 20120156175A1
• Filed: 06/21/2011
• Published: 06/21/2012
• Est. Priority Date: 12/20/2010
• Status: Active Grant

• Current Assignee: Ajou University Industry
• Original Assignee: Ajou University Industry
• Inventors: LEE, Myung Ae, Jeon, Jeong Yong
• Granted Patent: US 9,028,810 B2
• Time in Patent Office: Days
• US Class Current: 424/93.7
• CPC Class Codes: A61K 38/1709 from mammals
• CPC Class Codes: A61P 25/00 Drugs for disorders of the nervous system
• CPC Class Codes: A61P 25/28 for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: C07K 14/47 from mammals
• CPC Class Codes: C12N 2501/998 Proteins not provided for elsewhere
• CPC Class Codes: C12N 5/0619 Neurons
• CPC Class Codes: C12N 5/0623 Stem cells

Abstract

A novel use of periostin, and more particularly a composition for inducing the migration of neural stem cells, which contains periostin or a periostin-secreting cell as an active ingredient, based on the discovery of a novel function of periostin that induces the migration of neural stem cells. Periostin induces the migration of neural stem cells, and thus the composition for inducing the migration of neural stem cells, which contains periostin or periostin-secreting cells as an active ingredient, can be used in various applications based on neural stem cells. A pharmaceutical composition containing suicide gene-expressing neural stem cells and periostin allows the neural stem cells to effectively migrate to tumor tissues, and thus can be used as a cell therapeutic agent for treating cancer. Also, the pharmaceutical composition containing neural stem cells and periostin has improved effects on the stimulation of regeneration of nerve cells and the treatment of neural diseases.

Claims

1. A composition for inducing the migration of neural stem cells, the composition containing periostin or periostion-secreting cells as an active ingredient.

2. The composition for inducing the migration of neural stem cells according to claim 1, wherein the periostin comprises an amino acid sequence set forth in any one of SEQ ID NO:

1 to SEQ ID NO;

4.

3. A pharmaceutical composition for treating cancer diseases, the composition containing:

(a) neural stem cells expressing a suicide gene; and

(b) periostin or periostin-secreting cells.

4. The pharmaceutical composition for treating cancer diseases, wherein the cancer disease is selected from the group consisting of brain tumor, ovarian cancer, lung cancer and breast cancer.

5. A composition for stimulating the regeneration of nerve cells, the composition containing:

(a) neural stem cells; and

(b) periostin or periostin-secreting cells.

6. A pharmaceutical composition for treating neural disease, the composition containing:

(a) neural stem cells; and

(b) periostin or periostin-secreting cells.

7. The composition according to claim 6, the neural disease is selected from the group consisting of brain injury, dementia, Parkinson'"'"'s disease, Alzheimer'"'"'s disease, Huntington'"'"'s disease, epilepsy, paralysis, stroke, ischemic brain disease, degenerative brain disease, peripheral nerve injury, amyotropic laterial sclerosis and peripheral nerve disease.

8. A method for treating cancer diseases, the method including administering (a) neural stem cells expressing a suicide gene;

and (b) periostin or periostin-secreting cells.

9. A method for treating neural disease, the method including administering periostin or periostin-secreting cells.

10. The method for treating neural disease according to claim 9, wherein neural stem cells are further administered.