Brownian Microbarcodes for Bioassays
First Claim
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1. A system for genetic research, comprising:
- an objective lens;
a light engine;
a microscope stage, wherein the stage comprises robotics to move the stage in the x, y and z directions, and wherein the stage accepts trays about the size of a standard 96-well plate;
a tray, wherein the tray is designed to fit at least one microarray cartridge, at least one glass microscope slide and is about the size of the standard 96-well plate;
an electronics module, wherein the electronics module supplies power and controls the operation of all electronic components of the system;
a filter cube; and
a camera.
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Abstract
Presented are encoded microparticles, methods of use in biological assays, and flexible, modular instrument systems for conducting a variety of biological assays using the encoded microparticles. The systems include various instrumentation components which are exchangeable and offer a single flexible platform on which a large number of different types of experiments and assays may be conducted including, for example, microarray analysis, encoded microparticle single and multiplex detection, tissue dissection and isolation, and other genetic analysis techniques.
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Citations
21 Claims
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1. A system for genetic research, comprising:
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an objective lens; a light engine; a microscope stage, wherein the stage comprises robotics to move the stage in the x, y and z directions, and wherein the stage accepts trays about the size of a standard 96-well plate; a tray, wherein the tray is designed to fit at least one microarray cartridge, at least one glass microscope slide and is about the size of the standard 96-well plate; an electronics module, wherein the electronics module supplies power and controls the operation of all electronic components of the system; a filter cube; and a camera. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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15. A system for genetic research, comprising:
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an objective lens; a light engine; a microscope stage, wherein the stage comprises robotics to move the stage in the x, y and z directions, and wherein the stage accepts trays about the size of a standard 96-well plate; a tray, wherein the tray is designed to fit at least one microarray cartridge, at least one glass microscope slide and is about the size of the standard 96-well plate; an electronics module, wherein the electronics module supplies power and controls the operation of all electronic components of the system; a filter cube; and a camera, wherein the system is adapted to visualize and detect at least one encoded microparticle, wherein the encoded microparticle comprises; a longest dimension less than 50 microns; a plurality of segments, wherein the plurality of segments form a spatial code; and an outer surface, wherein the outer surface encloses the spatial code, and wherein the spatial code is detectable through the outer surface. - View Dependent Claims (16, 17, 18, 19, 20, 21)
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Specification