High-Speed, High-Resolution Electrophysiology In-Vivo Using Conformal Electronics
First Claim
Patent Images
1. A device for interfacing with a tissue in a biological environment, the device comprising:
- a flexible or stretchable substrate;
a flexible or stretchable electronic circuit comprising one or more inorganic semiconductor circuit elements supported by the flexible or stretchable substrate; and
a barrier layer encapsulating at least a portion of the flexible or stretchable electronic circuit;
wherein the barrier layer and the flexible or stretchable substrate limit a net leakage current from the flexible or stretchable electronic circuit to an amount which does not adversely affect the tissue; and
wherein the flexible or stretchable substrate, the flexible or stretchable electronic circuit and the barrier layer provide a net bending stiffness of the device low enough that the device establishes conformal contact with the tissue in the biological environment.
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Abstract
Provided herein are biomedical devices and methods of making and using biomedical devices for sensing and actuation applications. For example, flexible and/or stretchable biomedical devices are provided including electronic devices useful for establishing in situ conformal contact with a tissue in a biological environment. The invention includes implantable electronic devices and devices administered to the surfaces(s) of a target tissue, for example, for obtaining electrophysiology data from a tissue such as cardiac, brain tissue or skin.
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Citations
90 Claims
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1. A device for interfacing with a tissue in a biological environment, the device comprising:
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a flexible or stretchable substrate; a flexible or stretchable electronic circuit comprising one or more inorganic semiconductor circuit elements supported by the flexible or stretchable substrate; and a barrier layer encapsulating at least a portion of the flexible or stretchable electronic circuit; wherein the barrier layer and the flexible or stretchable substrate limit a net leakage current from the flexible or stretchable electronic circuit to an amount which does not adversely affect the tissue; and
wherein the flexible or stretchable substrate, the flexible or stretchable electronic circuit and the barrier layer provide a net bending stiffness of the device low enough that the device establishes conformal contact with the tissue in the biological environment. - View Dependent Claims (8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58)
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2. A device for interfacing with a tissue in a biological environment, the device comprising:
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a flexible or stretchable substrate; a flexible or stretchable electronic circuit comprising one or more inorganic semiconductor circuit elements supported by the flexible or stretchable substrate; and a barrier layer encapsulating at least a portion of the flexible or stretchable electronic circuit; wherein the barrier layer is patterned so as to selectively modulate physical contact, thermal contact, optical communication or electrical communication between the flexible or stretchable electronic circuit and the tissue in the biological environment; and
wherein the flexible or stretchable substrate, the flexible or stretchable electronic circuit and the barrier layer provide a net bending stiffness of the device low enough that the device establishes conformal contact with the tissue in the biological environment.
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3. A device for interfacing with a tissue in a biological environment, the device comprising:
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a flexible or stretchable substrate; a flexible or stretchable electronic circuit comprising one or more inorganic semiconductor circuit elements supported by the flexible or stretchable substrate; and a barrier layer encapsulating at least a portion of the flexible or stretchable electronic circuit; wherein the barrier layer and the flexible or stretchable substrate limits heat transfer from the flexible or stretchable electronic circuit to the tissue in the biological environment to an amount that does not adversely affect the tissue in the biological environment; and
wherein the flexible or stretchable substrate, the flexible or stretchable electronic circuit and the barrier layer provide a net bending stiffness of the device low enough that the device establishes conformal contact with the tissue in the biological environment.
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4. A device for interfacing with a tissue in a biological environment, the device comprising:
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a flexible or stretchable substrate; a flexible or stretchable electronic circuit comprising one or more inorganic semiconductor circuit elements supported by the flexible or stretchable substrate; and a barrier layer encapsulating at least a portion of the flexible or stretchable electronic circuit; wherein the barrier layer is patterned so as to provide one or more permeable regions that are selectively permeable to one or more target molecules to allow transport of the target molecules from the biological environment to the flexible or stretchable electronic circuit or from the flexible or stretchable electronic circuit to the biological environment; and
wherein the flexible or stretchable substrate, the flexible or stretchable electronic circuit and the barrier layer provide a net bending stiffness of the device low enough that the device establishes conformal contact with the tissue in the biological environment.
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5. A device for interfacing with a tissue in a biological environment, the device comprising:
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a flexible or stretchable substrate; a flexible or stretchable electronic circuit comprising one or more inorganic semiconductor circuit elements supported by the flexible or stretchable substrate; and a barrier layer encapsulating at least a portion of the flexible or stretchable electronic circuit; wherein the barrier layer is patterned so as to provide one or more impermeable regions that are impermeable to one or more target molecules to prevent transport of the target molecules from the biological environment to the flexible or stretchable electronic circuit or from the flexible or stretchable electronic circuit to the biological environment; and
wherein the flexible or stretchable substrate, the flexible or stretchable electronic circuit and the barrier layer provide a net bending stiffness of the device low enough that the device establishes conformal contact with the tissue in the biological environment.
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6. A device for interfacing with a tissue in a biological environment, the device comprising:
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a flexible or stretchable substrate; a flexible or stretchable electronic circuit comprising one or more inorganic semiconductor circuit elements supported by the flexible or stretchable substrate; and a barrier layer encapsulating at least a portion of the flexible or stretchable electronic circuit; wherein the barrier layer is patterned to provide one or more transparent regions, wherein the transparent regions transmit to or from the flexible or stretchable electronic circuit ultraviolet, visible or near-infrared electromagnetic radiation having a preselected wavelength distribution or wherein the barrier layer is patterned to provide one or more opaque regions that substantially prevent transmission to or from the flexible or stretchable electronic circuit of electromagnetic radiation having a preselected distribution of wavelengths in the ultraviolet, visible or near-infrared regions of the electromagnetic spectrum; and
wherein the flexible or stretchable substrate, the flexible or stretchable electronic device and the barrier layer provide a net bending stiffness of the device low enough that the device establishes conformal contact with the tissue in the biological environment.
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7. A device for interfacing with a tissue in a biological environment, the device comprising:
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a flexible or stretchable substrate; a flexible or stretchable electronic circuit supported by the flexible or stretchable substrate, wherein the flexible or stretchable electronic circuit comprises a plurality of sensors, actuators or both sensors and actuators provided in an array and one or more inorganic semiconductor circuit elements; a controller in communication with the flexible or stretchable electronic circuit, the controller configured to receive input signals from the flexible or stretchable electronic circuit and provide output signals to the flexible or stretchable electronic circuit, wherein the controller receives and analyzes input signals corresponding to one or more measurements from said sensors and generates output signals that control or provide one or more sensing or actuation parameter to the flexible or stretchable electronic circuit; and a barrier layer encapsulating at least a portion of the flexible or stretchable electronic circuit; wherein the flexible or stretchable substrate, the flexible or stretchable electronic circuit and the barrier layer provide a net bending stiffness of the device low enough that the device establishes conformal contact with the tissue in the biological environment.
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59. An device for collecting electrophysiology data from a tissue in a biological environment, the device comprising:
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a flexible or stretchable substrate; a flexible or stretchable electrode array comprising one or more inorganic semiconductor circuit elements and a plurality of electrode elements positioned in electrical communication with at least a portion of the semiconductor circuit elements, wherein the one or more inorganic semiconductor circuit elements include multiplex circuitry and amplification circuitry, and wherein the electrode array is supported by the flexible or stretchable substrate; a barrier layer encapsulating at least a portion of the flexible or stretchable electrode array to limit a net leakage current from flexible or stretchable electrode array to the tissue to an amount that does not adversely affect the tissue; wherein the flexible or stretchable substrate, the flexible or stretchable electrode array and the barrier layer provide a net bending stiffness of the device low enough that the device establishes conformal contact with the tissue in the biological environment, thereby, positioning at least one of the plurality of electrode elements in electrical communication with the tissue in the biological environment.
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60. A method of collecting electrophysiology data from a tissue in a biological environment, the method comprising the steps of:
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providing a conformable electronic device comprising; a flexible or stretchable substrate; a flexible or stretchable electrode array comprising one or more inorganic semiconductor circuit elements and a plurality of electrode elements positioned in electrical communication with at least a portion of the semiconductor circuit elements, wherein the one or more inorganic semiconductor circuit elements include multiplex circuitry and amplification circuitry, and wherein the electrode array is supported by the flexible or stretchable substrate; a barrier layer encapsulating at least a portion of the flexible or stretchable electrode array to limit a net leakage current from flexible or stretchable electrode array to the tissue to an amount that does not adversely affect the tissue; wherein the flexible or stretchable substrate, the flexible or stretchable electronic device and the barrier layer provide a net bending stiffness of the device low enough that the device establishes conformal contact with the tissue in the biological environment; contacting the tissue with the conformable electronic device, thereby establishing the conformal contact such that at least a portion of the plurality of electrode elements is provided in electrical communication with the tissue in the biological environment; and measuring voltages associated with the tissue in the biological environment on at least a portion of the plurality of electrode elements. - View Dependent Claims (61)
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62. A device for interfacing with a tissue in a biological environment, the device comprising:
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a flexible or stretchable substrate; a stretchable or flexible array of light emitting diodes comprising a plurality of light emitting diodes in electrical communication with a plurality of stretchable or flexible electrical interconnects, the stretchable or flexible array of light emitting diodes supported by the flexible or stretchable substrate; a barrier layer encapsulating at least a portion of the stretchable or flexible array of light emitting diodes to limit a net leakage current from the stretchable or flexible array of light emitting diodes to the tissue to an amount that does not adversely affect the tissue; wherein the flexible or stretchable substrate, stretchable or flexible array of light emitting diodes and the barrier layer provide a net bending stiffness of the device low enough that the device establishes conformal contact with the tissue in the biological environment. - View Dependent Claims (63)
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64. A method of interfacing an array of light emitting diodes with a tissue of a subject, the method comprising the steps of:
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providing a conformable device for interfacing with a tissue in a biological environment, the device comprising; a flexible or stretchable substrate; a stretchable or flexible array of light emitting diodes comprising a plurality of light emitting diodes in electrical communication with a plurality of stretchable or flexible electrical interconnects, the stretchable or flexible array of light emitting diodes supported by the flexible or stretchable substrate; a barrier layer encapsulating at least a portion of the stretchable or flexible array of light emitting diodes to limit a net leakage current from the stretchable or flexible array of light emitting diodes to the tissue to an amount that does not adversely affect the tissue;
wherein the flexible or stretchable substrate, stretchable or flexible array of light emitting diodes and the barrier layer provide a net bending stiffness of the device low enough that the device establishes conformal contact with the tissue in the biological environment; andcontacting the conformable device with the tissue of the subject, thereby establishing the conformal contact with the tissue in the biological environment.
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65. A method of sensing or actuating a tissue in a biological environment;
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providing a subject having the tissue in the biological environment; providing a conformable device, the device comprising a flexible or stretchable substrate; a flexible or stretchable electronic circuit supported by the flexible or stretchable substrate, wherein the flexible or stretchable electronic circuit comprises an plurality of sensors, actuators or both sensors and actuators provided in an array, wherein said sensors or actuators comprise one or more inorganic semiconductor circuit elements; and a barrier layer encapsulating at least a portion of the flexible or stretchable electronic circuit;
wherein the barrier layer and the flexible or stretchable substrate limit a net leakage current from the flexible or stretchable electronic circuit to an amount which does not adversely affect the tissue or said barrier layer is patterned so as to selectively modulate physical contact, thermal contact, optical communication or electrical communication between said flexible or stretchable electronic circuit and said tissue in said biological environment;wherein the flexible or stretchable substrate, the flexible or stretchable electronic circuit and the barrier layer provide a net bending stiffness of the device low enough that the conformable device establishes conformal contact with the tissue in the biological environment; contacting the tissue with the conformable device, thereby establishing the conformal contact such that at least a portion of the plurality of sensors, actuators or both sensors and actuators of the array is provided in physical contact, electrical communication, optical communication, fluid communication or thermal communication with the tissue in the biological environment; and sensing or actuating the tissue in contact with the conformable device. - View Dependent Claims (66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90)
- the method comprising;
Specification