MICROFLUIDIC SYSTEM AND BUBBLE MANIPULATION METHOD THEREOF

• US 20120160680A1
• Filed: 06/14/2011
• Published: 06/28/2012
• Est. Priority Date: 12/22/2010
• Status: Abandoned Application

• Current Assignee: National Chiao Tung University (Government of The Republic of China)
• Original Assignee: National Chiao Tung University (Government of The Republic of China)
• Inventors: FAN, SHIH-KANG, TSAI, LING-PIN
• Application Number:
  US13/159,746
• Publication Number:
  US 20120160680A1
• Time in Patent Office: Days
• US Class Current: 204/451
• CPC Class Codes: B01L 2200/0673 Handling of plugs of fluid surrounded by immiscible fluid
• CPC Class Codes: B01L 3/502792 for moving individual droplets on a plate, e.g. by locally altering surface tension

Abstract

A microfluidic system includes a first electrode plate having a first substrate and a first electrode layer, wherein the first electrode layer has a plurality of continuously-arranged driving electrodes; a second electrode plate having a second substrate and a second electrode layer, wherein the second electrode layer corresponds to the first electrode layer; a spacing structure disposed between the first electrode plate and the second electrode plate so as to define a fluidic space therebetween; at least one fluid manipulatably received in the fluidic space, wherein the fluid has at least one gas bubble having a reaction gas thereinside, and the gas bubble is an enclosure structure. An electric potential is applied for driving the fluid and then controlling the position of the gas bubble. A gas breakdown voltage is applied to electrically discharge the gas in the gas bubble.

Claims

1. A bubble-manipulating microfluidic system, comprising:

a first electrode plate having a first substrate and a first electrode layer disposed on a surface of the first substrate, wherein the first electrode layer has a plurality of continuously-arranged driving electrodes;

a second electrode plate having a second substrate and a second electrode layer disposed on a surface of the second substrate, wherein the second electrode layer faces to the first electrode layer;

a spacing structure disposed between the first electrode plate and the second electrode plate so as to define a fluidic space therebetween;

at least one fluid manipulatably in the fluidic space, wherein the fluid carries at least one gas bubble having a reaction gas thereinside, and the gas bubble is an enclosed environment.

2. The microfluidic system as claimed in claim 1, wherein the first electrode plate further has a first dielectric layer disposed on the first electrode layer, and the second electrode plate further has a second dielectric layer disposed on the second electrode layer.

3. The microfluidic system as claimed in claim 2, wherein the first electrode plate further has a first hydrophobic layer disposed on the first dielectric layer, and the second electrode plate further has a second hydrophobic layer disposed on the second dielectric layer.

4. The microfluidic system as claimed in claim 1, wherein the first electrode plate further has a first hydrophobic layer disposed on the first electrode layer, and the second electrode plate further has a second hydrophobic layer disposed on the second electrode layer.

5. The microfluidic system as claimed in claim 1, wherein the enclosed environment is defined by the first electrode plate, the second electrode plate and the fluid.

6. The microfluidic system as claimed in claim 1, further comprising at least one gas inlet unit, a gas outlet unit and a spacer unit.

7. A bubble manipulation method, comprising the steps of:

providing a bubble-manipulating microfluidic system, wherein the bubble-manipulating microfluidic system includes a first electrode plate having a first substrate and a first electrode layer, a second electrode plate having a second substrate and a second electrode layer, a spacing structure disposed between the first electrode plate and the second electrode plate and at least one fluid manipulatably in a fluidic space defined between the first electrode plate and the second electrode plate, the fluid carries at least one gas bubble having a reaction gas thereinside;

wherein the first electrode layer has a plurality of continuously-arranged driving electrodes, and the second electrode layer faces to the first electrode layer;

driving the fluid in the fluidic space by applying an electric potential to the first and the second electrode layers; and

simultaneously pushing the gas bubble due to the movement of the fluid.

8. The method as claimed in claim 7, further comprising the steps of:

driving and fixing the gas bubble on one of the driving electrodes by applying the electric potential to the first and the second electrode layers; and

electrically discharging the reaction gas inside the gas bubble by applying a gas breakdown voltage to said one of the driving electrodes.

9. The method as claimed in claim 8, wherein in the step of providing a bubble-manipulating microfluidic system, the method further includes the steps of:

generating a first gas bubble by applying a proper electric potential to the first and second electrode layers from a first gas reservoir provided through a first gas inlet unit;

generating a second gas bubble by applying a proper electric potential to the first and second electrode layers from a second gas reservoir provided through a second gas inlet unit; and

preparing a reaction gas bubble by mixing the first and second gas bubbles driven by applying an electric potential to the first and the second electrode layers.

10. The method as claimed in claim 9, wherein after the step of mixing the first and the second gas bubbles, the method further includes the steps of:

separating the reaction gas bubble as at least two separated gas bubbles by applying the electric potential to the first and the second electrode layers to drive the fluid, wherein one of the separated gas bubbles has a first gas mixture, the other of the separated gas bubbles has a second gas mixture; and

providing a gas outlet unit to exhaust the second gas mixture.

11. The method as claimed in claim 8, wherein after the step of applying a gas breakdown voltage to electrically discharge the reaction gas, the method further includes the step of:

driving the gas bubble with the electrically discharging reaction gas along the driving electrodes by adjusting the electric potential applied to the first and the second electrode layers.

12. The method as claimed in claim 7, wherein in the step of providing a bubble-manipulating microfluidic system, the method further includes the steps of:

generating a first gas bubble by applying a proper electric potential to the first and second electrode layers from a first gas reservoir provided through a first gas inlet unit;

generating a second gas bubble by applying a proper electric potential to the first and second electrode layers from a second gas reservoir provided through a second gas inlet unit;

preparing a reaction gas bubble by mixing the first and second gas bubbles driven by applying an electric potential to the first and the second electrode layers;

driving and fixing the reaction gas bubble on one of the driving electrodes by applying the electric potential to the first and the second electrode layers; and

reacting the reaction gas inside the reaction gas bubble by applying a gas breakdown voltage to said one of the driving electrodes.

13. The method as claimed in claim 12, wherein after the step of mixing the first and the second gas bubbles, the method further includes the steps of:

separating the reaction gas bubble as at least two separated gas bubbles by applying the electric potential to the first and the second electrode layers to drive the fluid, wherein one of the separated gas bubbles has a first gas mixture, the other of the separated gas bubbles has a second gas mixture; and

providing a gas outlet unit to exhaust the second gas mixture.