Polymer Based Lanthanide Luminescent Sensors for the Detection of Organophosphorus Compounds

• US 20120164027A1
• Filed: 08/26/2008
• Published: 06/28/2012
• Est. Priority Date: 04/28/1998
• Status: Abandoned Application

• Current Assignee: Amanda L. Jenkins, George M. Murray, Uy O. Manuel
• Original Assignee: Amanda L. Jenkins, George M. Murray, Uy O. Manuel
• Inventors: Murray, George M., Uy, O. Manuel, Jenkins, Amanda L.
• Application Number:
  US12/198,427
• Publication Number:
  US 20120164027A1
• Time in Patent Office: Days
• US Class Current: 422/69
• CPC Class Codes: G01N 2021/772 Tip coated light guide
• CPC Class Codes: G01N 21/6428 Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" in vivo A61B5/00; immunoassay G01N33/53
• CPC Class Codes: G01N 21/7703 using reagent-clad optical fibres or optical waveguides using measurement of total internal reflection or attenuated total reflection G01N21/552; optical fibres or waveguides per se G02B
• CPC Class Codes: Y10T 436/11 Automated chemical analysis
• CPC Class Codes: Y10T 436/163333 Organic [e.g., chemical warfare agents, insecticides, etc.]
• CPC Class Codes: Y10T 436/17 Nitrogen containing

Abstract

A device for measuring and detecting the organophosphorus compounds, such as a pesticides or a nerve agents is provided. The devices function by selectively binding an organophosphorous compound to a luminescent functionality-imprinted copolymer. The copolymers possess a securely bound luminescent lanthanide ion, such as Eu³⁺, in a coordination complex that has been templated for the chemical functionality.

Claims

1. A surface acoustic wave sensor for detecting the presence of an organophosphorus compound, comprising:

a film of a MIP containing a lanthanide-complex disposed on a substrate selected from the group consisting of alumina and quartz crystal;

input and output transducers disposed on the film or substrate; and

a function generator operatively associated with the input transducer for generating a surface acoustic wave along a delay line.

2. The device of claim 1, wherein the lanthanide is selected from the group consisting of:

lanthanum, cerium, praseodymium, neodymium, promethium, samarium, europium, gadolinium, terbium, dysprosium, holmium, erbium, thulium, ytterbium, and lutetium.

3. The device of claim 1, wherein the organophosphorus compound is a member selected from the group consisting of soman, sarin, tabun, VX, malathion, parathion, paraoxon, diazinon and hydrolysis products thereof.

4. The device of claim 1, wherein the organophosphorus compound is pinacolylmethylphosphonate.

5. A dosimeter for detecting the presence of a organophosphorus compound, comprising:

a MIP containing a lanthanide-complex disposed on a substrate, wherein the lanthanide-complex is capable of chemically binding with said organophosphorus compound.

6. A method for making a MIP transducer for use in a sensor, the method comprising:

(a) mixing a lanthanide, an organophosphorus compound template and at least one imprint monomer to form a lanthanide complex;

(b) mixing the lanthanide complex with a polymerization initiator and a crosslinking agent to form a copolymer solution;

(c) partially curing the copolymer solution to obtain a partially cured copolymer;

(d) washing the partially cured copolymer to remove the organophosphorus compound template to obtain the MIP transducer.

7. The method of claim 6, wherein the lanthanide is selected from the group consisting of:

lanthanum, cerium, praseodymium, neodymium, promethium, samarium, europium, gadolinium, terbium, dysprosium, holmium, erbium, thulium, ytterbium, and lutetium.

8. The method of claim 6, wherein the organophosphorus compound is a member selected from the group consisting of soman, sarin, tabun, VX, malathion, parathion, paraoxon, diazinon and hydrolysis products thereof.

9. The method of claim 6, wherein the organophosphorus compound is pinacolylmethylphosphonate.

10. The method of claim 6, wherein the imprint monomer is selected from the group consisting of 4-vinyl benzoic acid, 2-hydroxy-1,2-di-4-vinylphenylethanone, 4-vinyl-2-hydroxybenzaldehyde oxime and methyl-3,5-divinyl benzoate.

11. The method of claim 6, wherein the crosslinking agent is a member selected from the group consisting of divinyl benzene, styrene, and azobisisobutylnitrile.

12. The method of claim 6, wherein the MIP transducer is a member selected from the group consisting of Eu(DVMB)₃PMP(NO₃)₂ and Eu(DVMB)₃(NO₃)₃.