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HUMAN MONOCLONAL ANTIBODIES AGAINST INTERLEUKIN 8 (IL-8)

  • US 20120164143A1
  • Filed: 12/27/2011
  • Published: 06/28/2012
  • Est. Priority Date: 12/16/2002
  • Status: Active Grant
First Claim
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1. A method of treating cancer mediated by human IL-8 comprising administering to a subject an effective amount of a monoclonal antibody which specifically binds to human IL-8 comprising:

  • (a) a heavy chain variable region comprising an amino acid sequence which is set forth in SEQ ID NO;

    12 or which is at least 95% homologous to SEQ ID NO;

    12 or which is encoded by a nucleic acid set forth in SEQ ID NO;

    10 or encoded by a nucleotide sequence which is at least 95% homologous to SEQ ID NO;

    10;

    or(b) a light chain variable region comprising an amino acid sequence which is set forth in SEQ ID NO;

    8 or which is at least 95% homologous to SEQ ID NO;

    8 or which is encoded by a nucleic acid set forth in SEQ ID NO;

    6 or which is encoded by a nucleotide sequence which is at least 95% homologous to SEQ ID NO;

    6.

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