METHODS AND COMPOSITIONS FOR DIRECTED MICROWAVE CHEMISTRY
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Abstract
The present invention concerns a novel means by which chemical preparations can be made. Reactions can be accelerated on special cartridges using microwave energy. The chips contain materials that efficiently absorb microwave energy causing chemical reaction rate increases. The invention is important in many chemical transformations including those used in protein chemistry, in nucleic acid chemistry, in analytical chemistry, and in the polymerase chain reaction.
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Citations
44 Claims
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1-24. -24. (canceled)
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25. A method for accelerating a biospecific binding reaction involving one or more reactant(s) and a carrier fluid, wherein the one or more reactant(s) comprises one or more nucleic acid(s), said method comprising:
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(a) contacting a composite material with said reactant(s) and carrier fluid, said composite material comprising a solid material susceptible to microwave heating and capture molecules, wherein the capture molecules comprise one or more nucleic acid(s), said contacting being under conditions sufficient to allow said reactant(s) to bind to said capture molecule(s) of said composite via a biospecific interaction; (b) applying an electromagnetic field to said composite material, wherein the wavelength of the electromagnetic field is between 1 cm and 100 m and is sufficient to result in microwave heating of said solid material; and (c) allowing said composite material to transfer heat to said reactant(s); (d) whereby product is formed from said reactant(s) and said capture molecule(s) at a greater rate than without heating from the heated composite material, thereby accelerating said biospecific binding reaction. - View Dependent Claims (26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44)
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Specification