×

Peptide-Based In Vivo siRNA Delivery System

  • US 20120165393A1
  • Filed: 12/15/2011
  • Published: 06/28/2012
  • Est. Priority Date: 12/17/2010
  • Status: Active Grant
First Claim
Patent Images

1. A conjugate delivery system composition for delivering an RNA interference polynucleotide to a liver cell in vivo comprising:


  • RNAi-A+Melittin−

    (L−

    Gal)x wherein,Melittin is a melittin peptideL is physiologically labile linkage,Gal is an Asialoglycoprotein Receptor (ASGPr) ligand,x is an integer having a value greater than 80% of primary amines of Melittin, RNAi is an RNA interference polynucleotide, andA is either a hydrophobic group having at least 20 carbon atoms or a galactose cluster.

View all claims
  • 3 Assignments
Timeline View
Assignment View
    ×
    ×