Device For The Transcutaneous, In Vivo Measurement Of The Concentration Of At Least One Analyte In A Living Organism

• US 20120165625A1
• Filed: 06/02/2010
• Published: 06/28/2012
• Est. Priority Date: 06/09/2009
• Status: Active Grant

• Current Assignee: JOANNEUM RESEARCH Forschungsgesellschaft mbH (Province of Styria), Technische Universität Graz, Technische Universitat Munchen
• Original Assignee: JOANNEUM RESEARCH Forschungsgesellschaft mbH (Province of Styria), Technische Universität Graz
• Inventors: Köhler, Hans, Klimant, Ingo, Babeluk, Michael
• Granted Patent: US 9,950,111 B2
• Time in Patent Office: Days
• US Class Current: 600/316
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14539 for measuring pH
• CPC Class Codes: A61B 5/14542 for measuring blood gases A61B5/14551 takes precedence
• CPC Class Codes: A61B 5/14556 by fluorescence A61B5/14555 takes precedence
• CPC Class Codes: A61B 5/1459 invasive, e.g. introduced into the body by a catheter A61B5/1464 takes precedence
• CPC Class Codes: A61B 5/415 the glands, e.g. tonsils, adenoids or thymus
• CPC Class Codes: A61M 2005/1726 the body parameters being measured at, or proximate to, the infusion site
• CPC Class Codes: A61M 2205/3306 Optical measuring means
• CPC Class Codes: A61M 2230/201 Glucose concentration
• CPC Class Codes: A61M 2230/205 partial oxygen pressure (P-O2)
• CPC Class Codes: A61M 2230/208 pH-value
• CPC Class Codes: A61M 5/1723 using feedback of body parameters, e.g. blood-sugar, pressure measurement of body parameters A61B5/00

Abstract

The invention relates to a device for the transcutaneous, in vivo measurement of the concentration of at least one analyte in a living organism, comprising a carrier which can be introduced into the organism, and a luminescence indicator which is immobilized on the carrier and which reacts to a change in the concentration of the analyte to be measured with a change in at least one optical property, wherein the luminescence indicator is transcutaneously connected to a source for providing the excitation radiation and a detector for detecting the measuring radiation. According to the invention, the luminescence indicator is immobilized on the outer circumference of a catheter, which is used to dispense a fluid medium, for example a medicament, into the organism or to suck up a body fluid.

Claims

1. Device for transcutaneous in vivo measurement of the concentration of at least one analyte in a living organism, with a carrier insertable into the organism and, immobilized on the carrier, a luminescence indicator which reacts on a change of the concentration of the analyte to be measured with a change of at least one optical characteristic, wherein the luminescence indicator is transcutaneously connected with a source for providing the excitation radiation and a detector for detecting the measurement radiation, characterized in that the luminescence indicator is immobilized at the outer periphery of a catheter serving for delivery of a liquid medium, for example a medicament, into the organism or for sucking up a body fluid.

2. Device according to claim 1, characterized in that the luminescence indicator is immobilized in at least one segment of the catheter by physical fixation or chemical bonding.

3. Device according to claim 1, characterized in that the catheter has at its outer periphery a recess or an etching for reception of the luminescence indicator which is existent preferably in a carrier layer.

4. Device according to claim 1, characterized in that the device has a dosage unit for a medicament connected with the catheter, wherein the medicament dose is adjustable preferably depending on the analyte concentration measured by the luminescence indicator.

5. Device according to claim 1, characterized in that the catheter is positioned outwardly protruding in a base element of a housing wherein the base element is capable of being placed onto the surface of the organism under insertion of the catheter.

6. Device according to claim 5, characterized in that the housing houses the source for providing the excitation radiation, the detector for detecting the measurement radiation, and the dosage unit for delivery of a medicament.

7. Device according to claim 5, characterized in that there is existent in the housing an electronic unit which controls the provision of the excitation radiation and the detection of the measurement radiation, calculates the analyte concentration, and determines, depending on the analyte concentration, a medicament dose.

8. Device according to claim 7, characterized in that the electronic unit controls the dosage unit for the medicament and applies the determined medicament dose preferably automatically into the organism.

9. Device according to claim 1, characterized in that the analyte to be measured is an endogenous metabolite, for example glucose or lactate, or an exogenously administered substance.

10. Device for transcutaneous in vivo measurement of the concentration of at least one analyte in a living organism, with a carrier insertable into the organism and, immobilized on the carrier, a luminescence indicator which reacts on a change of the concentration of the analyte to be measured with a change of at least one optical characteristic,

wherein the luminescence indicator is transcutaneously connected with a source for providing the excitation radiation and a detector for detecting the measurement radiation,

wherein the luminescence indicator is immobilized at the outer periphery of a catheter serving for delivery of a liquid medium, for example a medicament, into the organism or for sucking up a body fluid;

the catheter is positioned outwardly protruding in a base element of a housing wherein the base element is capable of being placed onto the surface of the organism under insertion of the catheter; and

there is existent in the housing an electronic unit which controls the provision of the excitation radiation and the detection of the measurement radiation, calculates the analyte concentration, and determines, depending on the analyte concentration, a medicament dose.

11. Device for transcutaneous in vivo measurement of the concentration of at least one analyte in a living organism, with a carrier insertable into the organism and, immobilized on the carrier, a luminescence indicator which reacts on a change of the concentration of the analyte to be measured with a change of at least one optical characteristic,

wherein the luminescence indicator is transcutaneously connected with a source for providing the excitation radiation and a detector for detecting the measurement radiation,

wherein the luminescence indicator is immobilized at the outer periphery of a catheter serving for delivery of a liquid medium, for example a medicament, into the organism or for sucking up a body fluid;

and

the catheter has at its outer periphery a recess or an etching for reception of the luminescence indicator which is existent preferably in a carrier layer.