Systems and Methods for Improved In Vivo Analyte Sensor Function
First Claim
1. An electrochemical analyte sensor, comprising:
- a working electrode comprising a sensing layer disposed proximate thereto;
a counter electrode; and
an anti-inflammatory agent disposed proximate to the working electrode.
1 Assignment
0 Petitions
Accused Products
Abstract
Embodiments of the present disclosure relate to systems for improving the performance of one or more components of a sensor, such as an in vivo analyte sensor, including, for example, continuous and/or automatic in vivo analyte sensors, by detecting inflammation at an insertion site and adjusting the signal of the sensor, adjusting the display of the signal (e.g., inactivation of display), or indicating administration of an anti-inflammatory agent, such as an interleukin 1 receptor antagonist. Embodiments of the present disclosure also relate to analyte determining methods and devices (e.g., electrochemical analyte monitoring systems) that have improved signal response and stability by inclusion of one or more of a clot activator and/or an immunosuppressant proximate to a working electrode of an in vivo analyte sensor. Also provided are systems and methods of using the, for example electrochemical, analyte sensors in analyte monitoring.
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Citations
95 Claims
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1. An electrochemical analyte sensor, comprising:
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a working electrode comprising a sensing layer disposed proximate thereto; a counter electrode; and an anti-inflammatory agent disposed proximate to the working electrode. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. A method for monitoring a level of an analyte in a subject, the method comprising:
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positioning at least a portion of an analyte sensor into skin of a subject, wherein the analyte sensor comprises; a working electrode comprising a sensing layer disposed proximate thereto; a counter electrode; and an anti-inflammatory agent disposed proximate to the working electrode, and determining a level of an analyte over a period of time from signals generated by the analyte sensor, wherein the determining over a period of time provides for monitoring the level of the analyte in the subject. - View Dependent Claims (15, 16, 17, 18, 19, 20, 21, 22, 23, 24)
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25. A method for monitoring a level of an analyte using an analyte monitoring system, the method comprising:
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inserting at least a portion of an analyte sensor into skin of a subject, the analyte sensor comprising; a working electrode comprising a sensing layer disposed proximate thereto; a counter electrode; and an inflammation detector; determining a level of an analyte over a period of time from signals generated by the analyte sensor, wherein during the determining the level of the analyte during the period of time, the method further comprises determining the presence or absence of inflammation proximate to the analyte sensor positioned in the skin of the subject, and wherein the determining over a period of time provides for monitoring the level of the analyte in the subject. - View Dependent Claims (26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36)
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37. An electrochemical analyte sensor, comprising:
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a working electrode comprising a sensing layer disposed proximate thereto; a counter electrode; and a clot activator disposed proximate to the working electrode. - View Dependent Claims (38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49)
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50. A method for monitoring a level of an analyte in a subject, the method comprising:
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positioning at least a portion of an analyte sensor into skin of a subject, wherein the analyte sensor comprises; a working electrode comprising a sensing layer disposed proximate thereto; a counter electrode; and a clot activator disposed proximate to the working electrode, and determining a level of an analyte over a period of time from signals generated by the analyte sensor, wherein the determining over a period of time provides for monitoring the level of the analyte in the subject. - View Dependent Claims (51, 52, 53, 54, 55, 56, 57, 58, 59, 60)
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61-71. -71. (canceled)
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72. An electrochemical analyte sensor, comprising:
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a substrate; a working electrode disposed on the substrate, wherein the working electrode comprises a sensing layer disposed proximate to the working electrode; a counter electrode; and an immunosuppressant disposed proximate to an exterior surface of the substrate. - View Dependent Claims (73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83)
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84. A method for monitoring a level of an analyte in a subject, the method comprising:
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positioning at least a portion of an analyte sensor into skin of a subject, wherein the analyte sensor comprises; a substrate; a working electrode disposed on the substrate, wherein the working electrode comprises a sensing layer disposed proximate to the working electrode; a counter electrode; and an immunosuppressant disposed proximate to an exterior surface of the substrate, and determining a level of an analyte over a period of time from signals generated by the analyte sensor, wherein the determining over a period of time provides for monitoring the level of the analyte in the subject. - View Dependent Claims (85, 86, 87, 88, 89, 90, 91, 92, 93, 94)
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95-117. -117. (canceled)
Specification