FLUID ACCUMULATION MONITORING DEVICES, SYSTEMS AND METHODS

• US 20120165884A1
• Filed: 12/22/2010
• Published: 06/28/2012
• Est. Priority Date: 12/22/2010
• Status: Abandoned Application

• Current Assignee: Pacesetter Incorporated (Abbott Laboratories Incorporated)
• Original Assignee: Pacesetter Incorporated (Abbott Laboratories Incorporated)
• Inventors: Xi, Cecilia Qin, Rosenberg, Stuart, Gill, Jong, Nabutovsky, Yelena, Hsu, William, Wenzel, Brian Jeffrey
• Application Number:
  US12/975,794
• Publication Number:
  US 20120165884A1
• Time in Patent Office: Days
• US Class Current: 607/4
• CPC Class Codes: A61B 5/0537 Measuring body composition by impedance, e.g. tissue hydration or fat content
• CPC Class Codes: A61B 5/0538 invasively, e.g. using a catheter
• CPC Class Codes: A61B 5/4878 Evaluating oedema
• CPC Class Codes: A61B 5/7239 using differentiation including higher order derivatives
• CPC Class Codes: A61N 1/3627 for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy
• CPC Class Codes: A61N 1/36521 the parameter being derived from measurement of an electrical impedance

Abstract

Provided herein are implantable systems, and methods for use therewith, for monitoring a patient'"'"'s fluid accumulation level. A thoracic impedance signal for the patient is obtained. Based on the thoracic impedance signal, a duration metric indicative of a duration of drop of the thoracic impedance signal, a magnitude metric indicative of a magnitude of drop of the thoracic impedance signal, and a rate metric indicative of a rate of drop of the thoracic impedance signal is determined. The patient'"'"'s fluid accumulation level is monitored based on the duration metric, the magnitude metric and the rate metric.

Claims

1. For use with an implantable system, a method for monitoring fluid accumulation in a patient'"'"'s thoracic cavity, the method comprising:

(a) obtaining a thoracic impedance signal for the patient;

(b) determining, based on the thoracic impedance signal,

(b.1) a duration metric indicative of a duration of drop of the thoracic impedance signal,

(b.2) a magnitude metric indicative of a magnitude of drop of the thoracic impedance signal, and

(b.3) a rate metric indicative of a rate of drop of the thoracic impedance signal; and

(c) monitoring a fluid accumulation level based on the duration metric, the magnitude metric and the rate metric.

2. The method of claim 1, further comprises:

(d) triggering an alert, triggering therapy and/or adjusting therapy in response to detecting an abnormal fluid accumulation level.

3. The method of claim 1, wherein

step (b) further comprises determining, based on the thoracic impedance signal, an acceleration metric indicative of an acceleration of drop of the thoracic impedance signal;

and

the monitoring the fluid accumulation level at step (c) is also based on the acceleration metric.

4. The method of claim 1, wherein step (c) comprises:

(c.1) comparing the duration metric to a duration threshold;

(c.2) comparing the magnitude metric to a magnitude threshold;

(c.3) comparing the rate metric to a rate threshold; and

(c.4) monitoring an abnormal fluid accumulation level based on results of steps (c.1), (c.2) and (c.3).

5. The method of claim 4, further comprises:

determining, based on the thoracic impedance signal, an acceleration metric indicative of an acceleration of drop of the thoracic impedance signal; and

modifying at least one of the duration threshold, the magnitude threshold, and the rate threshold based on the acceleration metric.

6. The method of claim 4, wherein step (c.4) includes detecting an abnormal fluid accumulation level when at least one of the following events occur:

the duration metric reaches the duration threshold;

the magnitude metric reaches the magnitude threshold; and

the rate metric reaches the rate threshold.

7. The method of claim 4, wherein step (c.4) includes detecting an abnormal fluid accumulation level when at least two of the following events occur:

the duration metric reaches the duration threshold;

the magnitude metric reaches the magnitude threshold; and

the rate metric reaches the rate threshold.

8. The method of claim 4, wherein step (c.4) includes detecting an abnormal fluid accumulation level when all three of the following events occur:

the duration metric reaches the duration threshold;

the magnitude metric reaches the magnitude threshold; and

the rate metric reaches the rate threshold.

9. The method of claim 4, wherein step (c) further comprises:

(c.5) in response to detecting an abnormal fluid accumulation level, performing at least one of the following

(c.5.a) comparing the duration metric to one or more secondary duration threshold;

(c.5.b) comparing the magnitude metric to one or more secondary magnitude threshold; and

(c.5.c) comparing the rate metric to one or more secondary rate threshold; and

(c.6) determining a severity of the abnormal fluid accumulation based on results of step (c.5).

10. The method of claim 8, further comprises:

(d) triggering an alert, triggering therapy and/or adjusting therapy in response to detecting an abnormal fluid accumulation level and based on the determined severity of the fluid accumulation.

11. The method of claim 4, wherein step (c) further comprises:

(c.5) in response to detecting an abnormal fluid accumulation level, determining an acceleration metric indicative of an acceleration of drop of the thoracic impedance signal; and

(c.6) characterizing an onset of the detected abnormal fluid accumulation level based on results of step (c.5).

12. The method of claim 1, further comprising:

(d) storing within the implantable system information indicative of the monitored fluid accumulation level so that the stored information is available for transfer to a non-implanted system.

13. The method of claim 1, wherein step (b.1) comprises using a timer to determine the duration metric, which includes:

starting the timer in response to detecting that a slope of the thoracic impedance signal has been negative for at least a predetermined time;

resetting the timer when the slope of the thoracic impedance signal changes to positive for at least a predetermined reset time;

not resetting the timer when the slope of the thoracic impedance signal changes to positive for less than the predetermined reset time; and

after the slope drop duration time has been started, determining the duration metric based on a sum of the predetermined time and an amount of time since the timer had been started.

14. An implantable system configured to monitor fluid accumulation in a patient'"'"'s thoracic cavity, comprising:

one or more electrodes configured to obtain a thoracic impedance signal for the patient;

a fluid accumulation monitor configured to determine, based on the thoracic impedance signal,

a duration metric indicative of a duration of drop of the thoracic impedance signal,

a magnitude metric indicative of a magnitude of drop of the thoracic impedance signal, and

a rate metric indicative of a rate of drop of the thoracic impedance signal; and

wherein the fluid accumulation monitor is configured to monitor a fluid accumulation level based on the duration metric, the magnitude metric and the rate metric.

15. The implantable system of claim 14, wherein the fluid accumulation monitor is also configured to trigger an alert, therapy and/or adjust therapy in response to detecting an abnormal fluid accumulation level.

16. The implantable system of claim 14, wherein:

the fluid accumulation monitor is also configured to determine, based on the thoracic impedance signal, an acceleration metric indicative of an acceleration of drop of the thoracic impedance signal, and

the fluid accumulation monitor is configured to monitor the fluid accumulation level also based on the acceleration metric.

17. The implantable system of claim 14, wherein the fluid accumulation monitor is configured to:

compare the duration metric to a duration threshold;

compare the magnitude metric to a magnitude threshold;

compare the rate metric to a rate threshold; and

monitor for the abnormal fluid accumulation level based on results of the comparisons.

18. The implantable system of claim 17, wherein:

the fluid accumulation monitor is also configured to determine, based on the thoracic impedance signal, an acceleration metric indicative of an acceleration of drop of the thoracic impedance signal; and

the fluid accumulation monitor is configured to modify at least one of the duration threshold, the magnitude threshold, and the rate threshold based on the acceleration metric.

19. The implantable system of claim 17, wherein the fluid accumulation monitor is also configured to determine a severity of a detected abnormal fluid accumulation level based on results of comparing at least one of the duration metric, the magnitude metric, and the rate metric to one or more corresponding secondary threshold.

20. The implantable system of claim 17, wherein the fluid accumulation monitor is also configured to characterize an onset of a detected abnormal fluid accumulation level by determining an acceleration metric indicative of an acceleration of drop of the thoracic impedance signal, and comparing the acceleration metric to one or more acceleration threshold.

21. The implantable system of claim 14, further including a timing control mechanism including a timer to determine the duration metric, wherein the timing control mechanism:

starts the timer in response to detecting that a slope of the thoracic impedance signal has been negative for at least a predetermined time;

resets the timer when the slope of the thoracic impedance signal changes to positive for at least a predetermined reset time;

does not reset the timer when the slope of the thoracic impedance signal changes to positive for less than the predetermined reset time; and

after the slope drop duration time has been started, determines the duration metric based on a sum of the predetermined time and an amount of time since the timer had been started.

22. For use with an implantable system, a method comprising:

(a) obtaining a thoracic impedance signal indicative of fluid accumulation within a patient'"'"'s thoracic cavity;

(b) monitoring, based on the thoracic impedance signal,

a duration of drop of the thoracic impedance signal,

a magnitude of drop of the thoracic impedance signal, and

a rate of drop of the thoracic impedance signal; and

(c) monitoring for an abnormal fluid accumulation level based on the duration of drop, the magnitude of drop and the rate of drop of the thoracic impedance signal.

23. The method of claim 22, further comprising:

(d) in response to detecting an abnormal fluid accumulation level, determining a cause of the abnormal fluid accumulation level based on one or more of the duration of drop, the magnitude of drop and the rate of drop of the thoracic impedance signal.

24. The method of claim 22, further comprising:

(d) in response to detecting an abnormal fluid accumulation level, determining an acceleration of drop of the thoracic impedance signal, and characterizing an onset of the detected abnormal fluid accumulation level based on the acceleration of drop of the thoracic impedance signal.