CALIBRATION OF A HANDHELD DIABETES MANAGING DEVICE THAT RECEIVES DATA FROM A CONTINUOUS GLUCOSE MONITOR
First Claim
1. A method for calibrating a handheld diabetes managing device to determine an estimated glucose level of a patient from data generated by a continuous glucose monitor, comprising:
- sampling a current of the continuous glucose monitor at a sampling interval over a time period to generate a plurality of current samples for the time period, the current being related to a glucose level of the patient;
determining a mean of the plurality of current samples;
determining a median of the plurality of current samples;
determining a standard deviation of the plurality of current samples;
measuring a blood glucose level of the patient at a first time; and
determining a calibration equation that associates the plurality of current samples with the estimated glucose level of the patient based on the measured blood glucose level and the plurality of current samples when the standard deviation is less than a first threshold and an absolute value of a difference between the mean and median is less than a second threshold.
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Abstract
A method for calibrating a handheld diabetes managing device based on data generated by a continuous glucose monitor. The method can include sampling a current of the continuous glucose monitor at a sampling interval over a time period to generate a plurality of current samples for the time period. The method can also include determining a mean, median and standard deviation of the plurality of current samples. The blood glucose level of the patient can be measured at a first time and a calibration equation that associates the plurality of current samples with the estimated glucose level of the patient based on the measured blood glucose level and the plurality of current samples can be determined when the standard deviation is less than a first threshold and an absolute value of a difference between the mean and median is less than a second threshold.
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Citations
20 Claims
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1. A method for calibrating a handheld diabetes managing device to determine an estimated glucose level of a patient from data generated by a continuous glucose monitor, comprising:
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sampling a current of the continuous glucose monitor at a sampling interval over a time period to generate a plurality of current samples for the time period, the current being related to a glucose level of the patient; determining a mean of the plurality of current samples; determining a median of the plurality of current samples; determining a standard deviation of the plurality of current samples; measuring a blood glucose level of the patient at a first time; and determining a calibration equation that associates the plurality of current samples with the estimated glucose level of the patient based on the measured blood glucose level and the plurality of current samples when the standard deviation is less than a first threshold and an absolute value of a difference between the mean and median is less than a second threshold. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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15. A method for calibrating a handheld diabetes managing device to determine an estimated glucose level of a patient from data generated by a continuous glucose monitor, comprising:
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sampling a current of the continuous glucose monitor at a sampling interval over a time period to generate a plurality of current samples for the time period, the current being related to a glucose level of the patient; determining a mean of the plurality of current samples; determining a median of the plurality of current samples; determining a standard deviation of the plurality of current samples; determining a 25% quantile value of the plurality of current samples; determining a 75% quantile value of the plurality of current samples; determining a trend measure of the plurality of current samples, the trend measure corresponding to a change in the current over the time period; measuring a blood glucose level of the patient at a first time; and determining a linear calibration equation that associates the plurality of current samples with the estimated glucose level of the patient based on the measured blood glucose level and the plurality of current samples when (i) the standard deviation is less than a first threshold, (ii) an absolute value of a difference between the mean and median is less than a second threshold, (iii) the median minus the 25% quantile value is less than a third threshold, (iv) the 75% quantile value minus the median is less than a fourth threshold, and (v) an absolute value of the trend measure is less than a fifth threshold. - View Dependent Claims (16, 17, 18, 20)
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19. A diabetes management system that periodically determines an estimated glucose level of a patient, comprising:
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a continuous glucose monitor configured to;
(i) sample a current related to a glucose level of the patient at a sampling interval over a time period to generate a plurality of current samples for the time period, (ii) determine a mean of the plurality of current samples, (iii) determine a median of the plurality of current samples, and (iv) determine a standard deviation of the plurality of current samples; anda handheld diabetes managing device in communication with the continuous glucose monitor and configured to;
(i) measure a blood glucose level of the patient at a first time, (ii) receive the mean, median and standard deviation of the plurality of current samples from the continuous glucose monitor, (iii) determine a calibration equation that associates the plurality of current samples with the estimated glucose level of the patient based on the measured blood glucose level and the plurality of current samples when the standard deviation is less than a first threshold and an absolute value of a difference between the mean and median is less than a second threshold, and (iv) determine the estimated glucose level of the patient based on the calibration equation and the current sampled by the continuous glucose monitor.
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Specification