Durable Antimicrobial Composition Including a Surfactant

• US 20120171300A1
• Filed: 10/10/2011
• Published: 07/05/2012
• Est. Priority Date: 12/30/2010
• Status: Abandoned Application

• Current Assignee: Kimberly-Clark Worldwide Incorporated (Kimberly-Clark Corporation)
• Original Assignee: Kimberly-Clark Worldwide Incorporated (Kimberly-Clark Corporation)
• Inventors: Koenig, David William, Cunningham, Corey Thomas, Paulsen, Jeremy David, Vongsa, Rebecca Ann
• Application Number:
  US13/269,922
• Publication Number:
  US 20120171300A1
• Time in Patent Office: Days
• US Class Current: 424/616
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 2800/594 Mixtures of polymers
• CPC Class Codes: A61K 2800/596 Mixtures of surface active compounds
• CPC Class Codes: A61K 31/19 Carboxylic acids, e.g. valproic acid salicylic acid A61K31/60
• CPC Class Codes: A61K 33/02 Ammonia; Compounds thereof
• CPC Class Codes: A61K 33/40 Peroxides
• CPC Class Codes: A61K 8/22 Peroxides; Oxygen; Ozone
• CPC Class Codes: A61K 8/365 Hydroxycarboxylic acids; Ketocarboxylic acids
• CPC Class Codes: A61K 8/416 Quaternary ammonium compounds A61K8/35 takes precedence
• CPC Class Codes: A61K 8/8152 Homopolymers or copolymers of esters, e.g. (meth)acrylic acid esters; Compositions of derivatives of such polymers
• CPC Class Codes: A61K 8/817 Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen; Compositions or derivatives of such polymers, e.g. vinylimidazol, vinylcaprolactame, allylamines (Polyquaternium 6)
• CPC Class Codes: A61K 8/84 obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
• CPC Class Codes: A61K 8/86 Polyethers
• CPC Class Codes: A61K 8/88 Polyamides
• CPC Class Codes: A61P 31/04 Antibacterial agents
• CPC Class Codes: A61P 31/10 Antimycotics
• CPC Class Codes: A61P 31/12 Antivirals
• CPC Class Codes: A61Q 17/005 Antimicrobial preparations
• CPC Class Codes: Y02A 50/30 Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

The present invention relates to compositions having durable antimicrobial activity. The compositions include a carbonate/bicarbonate salt of a quaternary ammonium cation, an organic acid, hydrogen peroxide, a surfactant and a polymer. The polymer is selected from cationic amine polymer-epichlorohydrin adduct, cationic amine polymer-epichlorohydrin resin, poly(methacrylamidopropyltrimethylammonium)chloride, poly(bis(2-chloroethyl)ether-alt-1,3-bis(dimethylamino)propyl)urea, poly(diallyldimethylammonium)chloride, poly(t-butyl acrylate co-ethyl acrylate co-methacrylic acid), polyethylene oxide, polyquaternium-16, polyquaternium-22, polyquatemium-67 and combinations thereof. The surfactant is selected from cationic surfactants, non-ionic surfactants, zwitterionic surfactants and combinations thereof.

Claims

1. A composition having durable antimicrobial activity comprising:

a carbonate/bicarbonate salt of a quaternary ammonium cation;

an organic acid;

a surfactant selected from cationic surfactants, non-ionic surfactants, zwitterionic surfactants, and combinations thereof;

hydrogen peroxide; and

a polymer selected from cationic amine polymer-epichlorohydrin adduct, cationic amine polymer-epichlorohydrin resin, poly(methacrylamidopropyltrimethylammonium)chloride, poly(bis(2-chloroethyl)ether-alt-1,3-bis(dimethylamino)propyl)urea, poly(diallyldimethylammonium)chloride, poly(t-butyl acrylate co-ethyl acrylate co-methacrylic acid), polyethylene oxide, polyquatemium-16, polyquaternium-22, polyquaternium-67, and combinations thereof.

2. The composition of claim 1 wherein the carbonate/bicarbonate salt of a quaternary ammonium cation is selected from dioctyldimethylammonium carbonate, decyloctyldimethylammonium carbonate, didecyldimethylammonium carbonate, benzalkonium carbonate, benzethonium carbonate, stearalkonium carbonate, cetrimonium carbonate, behentrimonium carbonate, dioctyldimethylammonium bicarbonate, decyloctyldimethylammonium bicarbonate, didecyldimethylammonium bicarbonate, benzalkonium bicarbonate, benzethonium bicarbonate, stearalkonium bicarbonate, cetrimonium bicarbonate, behentrimonium bicarbonate, and combinations thereof.

3. The composition of claim 1 wherein the organic acid is selected from citric, malic, maleic, oxalic, glutaric, succinic, lactic, glycolic, fumaric, acetic, benzoic, propionic, sorbic, tartaric, formic, and combinations thereof.

4. The composition of claim 1 wherein the composition further comprises urea.

5. The composition of claim 1 wherein the composition retains antimicrobial activity after twenty-five insults of E. coli as measured by a log 2 reduction in organisms upon the twenty-fifth insult of 10⁶ total organisms.

6. The composition of claim 1 wherein the composition is effective against Gram positive bacteria, Gram negative bacteria, enveloped viruses, non-enveloped viruses, fungi, fungal spores, mildew and mold.

7. The composition of claim 1 wherein the composition includes from 0.2 to 15.0 percent by weight of the carbonate/bicarbonate salt of a quaternary ammonium cation.

8. The composition of claim 1 wherein the composition includes from 0.1 to 3.0 percent by weight of the organic acid.

9. The composition of claim 1 wherein the composition includes from 0.5 to 5.0 percent by weight of hydrogen peroxide.

10. The composition of claim 1 wherein the composition includes from 0.5 to 10.0 percent by weight of polymer.

11. The composition of claim 1 wherein the composition is incorporated into a nonwoven basesheet.

12. The composition of claim 1 wherein the surfactant is selected from ethoxylated alkylphenols, ethoxylated and propoxylated fatty alcohols, polyethylene glycol ethers of methyl glucose, polyethylene glycol ethers of sorbitol, ethylene oxide-propylene oxide block copolymers, ethoxylated esters of fatty (C_8-18) acids, condensation products of ethylene oxide with long chain amines or amides, condensation products of ethylene oxide with alcohols, alkyl ammonium salts, polymeric ammonium salts, alkyl pyridinium salts, aryl ammonium salts, alkyl aryl ammonium salts, silicone quaternary ammonium compounds, alkyl amine oxides, silicone amine oxides, and combinations thereof.

13. The composition of claim 1 wherein the composition includes from 0.05 to 3 percent by weight of the surfactant.