INTEGRATED APPARATUS FOR PERFORMING NUCLEIC ACID EXTRACTION AND DIAGNOSTIC TESTING ON MULTIPLE BIOLOGICAL SAMPLES
First Claim
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1. An apparatus configured to extract and amplify nucleic acid from a plurality of nucleic-acid containing samples, comprising:
- a rack comprising a plurality of lanes, each lane of the plurality of lanes comprisinga first location configured to receive one of the plurality of samples, anda second location configured to receive a reagent holder;
a magnetic separator configured to move adjacent to one or more of the second locations of the rack;
a liquid dispenser configured movable from a first position above one of the first locations to a second position above one of the second locations; and
a bay comprising at least one heat source and configured to receive a microfluidic cartridge, and configured to interact with the cartridge to separately amplify nucleic acid extracted from the plurality of samples.
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Abstract
The technology described herein generally relates to systems for extracting polynucleotides from multiple samples, particularly from biological samples, and additionally to systems that subsequently amplify and detect the extracted polynucleotides. The technology more particularly relates to microfluidic systems that carry out PCR on multiple samples of nucleotides of interest within microfluidic channels, and detect those nucleotides.
133 Citations
20 Claims
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1. An apparatus configured to extract and amplify nucleic acid from a plurality of nucleic-acid containing samples, comprising:
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a rack comprising a plurality of lanes, each lane of the plurality of lanes comprising a first location configured to receive one of the plurality of samples, and a second location configured to receive a reagent holder; a magnetic separator configured to move adjacent to one or more of the second locations of the rack; a liquid dispenser configured movable from a first position above one of the first locations to a second position above one of the second locations; and a bay comprising at least one heat source and configured to receive a microfluidic cartridge, and configured to interact with the cartridge to separately amplify nucleic acid extracted from the plurality of samples. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. A diagnostic apparatus, comprising:
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one or more racks, each configured to receive a number of samples and a corresponding number of holders, each holder configured to receive a process chamber and one or more receptacles configured to store reagents; a magnetic separator configured to move adjacent to the process chambers of a plurality of holders; a liquid dispenser movable from a first position above a first holder to a second position above a second holder, and movable from the first position above the first holder to a different position above the first holder; and one or more bays, each bay having a shape complementary to a shape of a microfluidic cartridge, wherein each bay is configured to cooperate with the cartridge to separately process a material extracted from the number of samples. - View Dependent Claims (14, 15, 16, 17, 18, 19, 20)
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Specification