METHODS FOR DECREASING THE INCIDENCE OF NECROTIZING ENTEROCOLITIS IN INFANTS, TODDLERS, OR CHILDREN USING HUMAN MILK OLIGOSACCHARIDES
First Claim
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1. A method of reducing the incidence of necrotizing enterocolitis in an infant in need thereof, toddler or child the method comprising administering to the infant, toddler, or child a composition comprising human milk oligosaccharides in a total amount of from about 0.001 mg/mL to about 20 mg/mL.
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Abstract
Disclosed are methods of reducing the incidence of necrotizing enterocolitis in an infant, toddler, or child using nutritional compositions including human milk oligosaccharides. The nutritional compositions including the human milk oligosaccharides are effective in reducing inflammation and the incidence of inflammatory diseases.
48 Citations
22 Claims
- 1. A method of reducing the incidence of necrotizing enterocolitis in an infant in need thereof, toddler or child the method comprising administering to the infant, toddler, or child a composition comprising human milk oligosaccharides in a total amount of from about 0.001 mg/mL to about 20 mg/mL.
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7. A method of reducing the incidence of necrotizing enterocolitis in an infant, toddler, and child in need thereof, the method comprising administering to the infant, toddler, or child a nutritional composition comprising 6′
- -sialyllactose, 2′
-fucosyllactose, and lacto-N-neotetraose. - View Dependent Claims (8, 9, 10, 11, 12)
- -sialyllactose, 2′
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13. A synthetic formula for improving the feeding tolerance of an infant, toddler, or child, the synthetic formula comprising from about 0.001 mg/mL to about 20 mg/mL of an oligosaccharide blend, wherein the oligosaccharide blend comprises a first oligosaccharide selected from the group consisting of a fructooligosaccharide, a galactooligosaccharide, lacto-N-neotetraose, 2′
- -fucosyllactose, and combinations thereof;
a second oligosaccharide selected from the group consisting of 3′
-sialyllactose, 6′
-sialyllactose, and combinations thereof; and
a third oligosaccharide selected from the group consisting of inulin, a gum, polydextrose, and combinations thereof. - View Dependent Claims (14, 15, 16, 17, 18, 19, 20)
- -fucosyllactose, and combinations thereof;
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21. A method of improving the feeding tolerance of an infant, toddler, or child in need thereof, the method comprising administering to the infant, toddler, or child a nutritional composition comprising from about 0.001 mg/mL to about 20 mg/mL of an oligosaccharide blend, wherein the oligosaccharide blend comprises a first oligosaccharide selected from the group consisting of a fructooligosaccharide, a galactooligosaccharide, lacto-N-neotetraose, 2′
- -fucosyllactose, and combinations thereof;
a second oligosaccharide selected from the group consisting of 3′
-sialyllactose, 6′
-sialyllactose, and combinations thereof; and
a third oligosaccharide selected from the group consisting of inulin, a gum, polydextrose, and combinations thereof.
- -fucosyllactose, and combinations thereof;
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22. A method of improving the feeding tolerance of an infant or toddler, in need thereof, the method comprising administering to the infant or toddler a synthetic pediatric formula comprising an oligosaccharide blend comprising a first oligosaccharide selected from the group consisting of fructooligosaccharide, galactooligosaccharide, lacto-N-neotetraose, 2′
- -fucosyllactose, and combinations thereof;
a second oligosaccharide selected from the group consisting of 3′
-sialyllactose, 6′
-sialyllactose, and combinations thereof; and
a third oligosaccharide selected from the group consisting of inulin, a gum, polydextrose, and combinations thereof.
- -fucosyllactose, and combinations thereof;
Specification