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FLUOROQUINOLONE DERIVATIVES OR SULFONAMIDE MOIETY-CONTAINING COMPOUNDS AS INHIBITORS OF TYROSYL-DNAPHOSPHODIESTERASE (TDP1)

  • US 20120172371A1
  • Filed: 10/27/2011
  • Published: 07/05/2012
  • Est. Priority Date: 10/27/2010
  • Status: Active Grant
First Claim
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1. A method for treating cancer in a subject, comprising administering to a subject having cancer a therapeutically effective amount of a topoisomerase I (TopI) inhibitor and a therapeutically effective amount of (i) a fluoroquinolone derivative that inhibits tyrosyl-DNA-phosphodiesterase 1 (Tdp1) activity or (ii) a sulfonamide moiety-containing compound that inhibits tyrosyl-DNA-phosphodiesterase 1 (Tdp1) activity, thereby treating the cancer in the subject.

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