Sensing Fluid Concentration for Continuous Glucose Monitoring
First Claim
1. An analyte monitor comprising:
- a plurality of fluid paths, each fluid path comprising a distal opening adapted to be disposed on one side of a stratum corneum layer of a user'"'"'s skin, a proximal opening adapted to be disposed on another side of the stratum corneum layer and an interior space extending between the distal and proximal openings;
a sensing zone in fluid communication with the proximal openings of the fluid paths;
sensing fluid extending from the sensing zone into substantially the entire interior space of the fluid paths; and
an analyte sensor adapted to detect a concentration of analyte in the sensing fluid within the sensing zone,wherein at least one of the sensing fluid and the analyte sensor comprises a catalyst for mutarotation of glucose.
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Accused Products
Abstract
An analyte monitor having a plurality of fluid paths, each fluid path having a distal opening adapted to be disposed on one side of a stratum corneum layer of a user'"'"'s skin, a proximal opening adapted to be disposed on another side of the stratum corneum layer and an interior space extending between the distal and proximal openings; a sensing zone in fluid communication with the proximal openings of the fluid paths; sensing fluid extending from the sensing zone into substantially the entire interior space of the fluid paths; and an analyte sensor adapted to detect a concentration of analyte in the sensing fluid within the sensing zone, wherein at least one of the sensing fluid and the analyte sensor comprises a catalyst for mutarotation of glucose. The invention also includes a method of using the monitor.
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Citations
25 Claims
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1. An analyte monitor comprising:
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a plurality of fluid paths, each fluid path comprising a distal opening adapted to be disposed on one side of a stratum corneum layer of a user'"'"'s skin, a proximal opening adapted to be disposed on another side of the stratum corneum layer and an interior space extending between the distal and proximal openings; a sensing zone in fluid communication with the proximal openings of the fluid paths; sensing fluid extending from the sensing zone into substantially the entire interior space of the fluid paths; and an analyte sensor adapted to detect a concentration of analyte in the sensing fluid within the sensing zone, wherein at least one of the sensing fluid and the analyte sensor comprises a catalyst for mutarotation of glucose. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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15. A method of in vivo monitoring of an individual'"'"'s interstitial fluid analyte concentration comprising:
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creating a plurality of fluid paths through a stratum corneum layer of an area of the individual'"'"'s skin, the fluid paths each comprising a distal end in analyte communication with interstitial fluid of the individual, a proximal end in fluid communication with a sensing zone located outside of the patient'"'"'s body, an interior space extending between the distal and proximal ends of the fluid path, and a sensing fluid filling substantially the entire interior space; and sensing concentration of glucose in the sensing fluid, the sensing step comprising catalyzing for mutarotation of glucose. - View Dependent Claims (16, 17, 18, 19, 20, 21, 22, 23, 24, 25)
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Specification