METHODS, SYSTEMS, AND COMPUTER READABLE MEDIA FOR NUCLEIC ACID SEQUENCING
First Claim
1. A method for nucleic acid sequencing, comprising:
- receiving a plurality of signals indicative of a parameter measured for a plurality of defined spaces, at least some of the defined spaces comprising one or more sample nucleic acids, the signals being responsive to a plurality of nucleotide flows introducing nucleotides to the defined spaces;
determining, for at least some of the defined spaces, whether the defined space comprises a sample nucleic acid;
processing, for at least some of the defined spaces determined to comprise a sample nucleic acid, the received signals to improve a quality of the received signals; and
predicting a plurality of nucleotide sequences corresponding to respective sample nucleic acids for the defined spaces based on the processed signals and the nucleotide flows.
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Abstract
A method for nucleic acid sequencing includes receiving a plurality of signals indicative of a parameter measured for a plurality of defined spaces, at least some of the defined spaces including one or more sample nucleic acids, the signals being responsive to a plurality of nucleotide flows introducing nucleotides to the defined spaces; determining, for at least some of the defined spaces, whether the defined space includes a sample nucleic acid; processing, for at least some of the defined spaces determined to include a sample nucleic acid, the received signals to improve a quality of the received signals; and predicting a plurality of nucleotide sequences corresponding to respective sample nucleic acids for the defined spaces based on the processed signals and the nucleotide flows.
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Citations
30 Claims
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1. A method for nucleic acid sequencing, comprising:
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receiving a plurality of signals indicative of a parameter measured for a plurality of defined spaces, at least some of the defined spaces comprising one or more sample nucleic acids, the signals being responsive to a plurality of nucleotide flows introducing nucleotides to the defined spaces; determining, for at least some of the defined spaces, whether the defined space comprises a sample nucleic acid; processing, for at least some of the defined spaces determined to comprise a sample nucleic acid, the received signals to improve a quality of the received signals; and predicting a plurality of nucleotide sequences corresponding to respective sample nucleic acids for the defined spaces based on the processed signals and the nucleotide flows. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23)
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24. A non-transitory machine-readable storage medium comprising instructions which, when executed by a processor, cause the processor to perform a method for nucleic acid sequencing comprising:
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receiving a plurality of signals indicative of a parameter measured for a plurality of defined spaces, at least some of the defined spaces comprising one or more sample nucleic acids, the signals being responsive to a plurality of nucleotide flows introducing nucleotides to the defined spaces; determining, for at least some of the defined spaces, whether the defined space comprises a sample nucleic acid; processing, for at least some of the defined spaces determined to comprise a sample nucleic acid, the received signals to improve a quality of the received signals; and predicting a plurality of nucleotide sequences corresponding to respective sample nucleic acids for the defined spaces based at least partly on the processed signals and the nucleotide flows. - View Dependent Claims (25, 26, 27, 28, 29)
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30. A system, comprising:
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a machine-readable memory; and a processor configured to execute machine-readable instructions, which, when executed by the processor, cause the system to perform steps including; receiving a plurality of signals indicative of a parameter measured for a plurality of defined spaces, at least some of the defined spaces comprising one or more sample nucleic acids, the signals being responsive to a plurality of nucleotide flows introducing nucleotides to the defined spaces; determining, for at least some of the defined spaces, whether the defined space comprises a sample nucleic acid; processing, for at least some of the defined spaces determined to comprise a sample nucleic acid, the received signals to improve a quality of the received signals; and predicting a plurality of nucleotide sequences corresponding to respective sample nucleic acids for the defined spaces based at least partly on the processed signals and the nucleotide flows.
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Specification