FUCOSYLLACTOSE AS BREAST MILK IDENTICAL NON-DIGESTIBLE OLIGOSACCHARIDE WITH NEW FUNCTIONAL BENEFIT

• US 20120177691A1
• Filed: 07/12/2010
• Published: 07/12/2012
• Est. Priority Date: 07/15/2009
• Status: Abandoned Application

• Current Assignee: nv nutricia
• Original Assignee: nv nutricia
• Inventors: Stahl, Bernd, Nauta, Alma Jildou, Garssen, Johan, Samain, Eric, Drouillard, Sophie
• Application Number:
  US13/383,822
• Publication Number:
  US 20120177691A1
• Time in Patent Office: Days
• US Class Current: 424/278.1
• CPC Class Codes: A23L 29/30 containing carbohydrate syrups; containing sugars; containing sugar alcohols, e.g. xylitol; containing starch hydrolysates, e.g. dextrin products from apiculture A23L21/20; artificial sweetening agents A23L27/30
• CPC Class Codes: A23L 33/10 using additives addition of substantially indigestible substances A23L33/21
• CPC Class Codes: A23L 33/125 containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates indigestible substances A23L33/21
• CPC Class Codes: A23L 33/40 Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
• CPC Class Codes: A23L 5/00 Preparation or treatment of foods or foodstuffs, in general; Food or foodstuffs obtained thereby; Materials therefor
• CPC Class Codes: A23V 2002/00 Food compositions, function of food ingredients or processes for food or foodstuffs
• CPC Class Codes: A23V 2200/308 having an effect on cancer prevention
• CPC Class Codes: A23V 2200/324 having an effect on the immune system
• CPC Class Codes: A23V 2250/28 Oligosaccharides
• CPC Class Codes: A61K 2039/55 characterised by the host/recipient, e.g. newborn with maternal antibodies
• CPC Class Codes: A61K 2039/572 cytotoxic response
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/702 Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
• CPC Class Codes: A61K 31/7032 attached to a polyol, i.e. compounds having two or more free or esterified hydroxy groups, including the hydroxy group involved in the glycosidic linkage, e.g. monoglucosyldiacylglycerides, lactobionic acid, gangliosides
• CPC Class Codes: A61K 39/39 characterised by the immunostimulating additives, e.g. chemical adjuvants
• CPC Class Codes: A61P 31/12 Antivirals
• CPC Class Codes: A61P 37/04 Immunostimulants

Abstract

The invention concerns nutritional compositions with fucosyllactose for use in stimulation of NK cells. The composition is suitable for infants.

Claims

1-9. -9. (canceled)

10. A method for treating and/or preventing viral infections caused by orthomyxoviridae, comprising administering to a mammal in need thereof an enteral composition comprising 2′

-fucosyllactose, wherein the composition is not human milk.

11. The method according to claim 10, wherein the orthomyxoviridae comprise influenza virus, herpesviridae, rotavirus, cytomegalovirus, respiratory syncytial virus, human imunodeficiency virus and/or rhinovirus.

12. The method according to claim 10, wherein the mammal suffers from common cold, flu, measles, chicken pox, viral gastro-enteritis, HIV infection and/or a viral respiratory tract infection.

13. The method according to claim 10, wherein the mammal is an infant, HIV patient, elderly and/or oncology patient.

14. The method according to claim 10, wherein the mammal is a human.

15. The method according to claim 14, wherein the mammal is a human infant.

16. The method according to claim 13, wherein the human is a HIV patient, an elderly person and/or an oncology patient.

17. The method according to claim 10, wherein the composition further comprises at least one of beta-galacto-oligosaccharides, fructo-oligosaccharides and uronic acid oligosaccharides.

18. The method according to claim 10, wherein the composition comprises 0.07 to 1 wt % fucosyllactose, based on dry weight of the composition.

19. The method according to claim 10, wherein the composition further comprises, based on total energy of the composition, 5 to 50% protein, 15 to 85% digestible carbohydrates and 5 to 50% fat.

20. A method for enhancing a vaccination response, comprising administering to a mammal an enteral composition comprising 2′

-fucosyllactose.

21. The method according to claim 20, wherein the response to vaccination with a viral antigen is enhanced.

22. An infant formula comprising 2′

-fucosyllactose.