MAGNETIC RESONANCE AND NON-MAGNETIC RESONANCE ANALYSIS

• US 20120178076A1
• Filed: 01/07/2011
• Published: 07/12/2012
• Est. Priority Date: 01/07/2011
• Status: Abandoned Application

• Current Assignee: Quality Electrodynamics (QED), LLC
• Original Assignee: Quality Electrodynamics (QED), LLC
• Inventors: FUJITA, Hiroyuki, Patrick, John L.
• Application Number:
  US12/986,442
• Publication Number:
  US 20120178076A1
• Time in Patent Office: Days
• US Class Current: 435/1.2
• CPC Class Codes: G01R 33/28 Details of apparatus provided for in groups G01R33/44 - G01R33/64
• CPC Class Codes: G01R 33/465 applied to biological material, e.g. in vitro testing
• CPC Class Codes: G01R 33/4808 Multimodal MR, e.g. MR combined with positron emission tomography [PET], MR combined with ultrasound or MR combined with computed tomography [CT]
• CPC Class Codes: G01R 33/4812 MR combined with X-ray or computed tomography [CT]

Abstract

In one embodiment, a hypothermic pulsatile perfusion (HPP) apparatus is described. The example HPP includes a chamber configured to house an object (e.g., kidney, liver, heart, skin graft) to be transplanted. The example HPP may include a nuclear magnetic resonance (NMR) element(s) (e.g., coil) configured to facilitate performing a first (e.g., magnetic resonance (MR) based) analysis of the object using a first set of frequencies. The example HPP may also include a spectrum element (e.g., optical probe) configured to facilitate performing a second (e.g., non-MR based) analysis of the object using a second, different set of frequencies. The HPP apparatus is constructed from MR compatible, non-ferromagnetic materials. In one embodiment, a combination MR/non-MR apparatus may apply MR and non-MR electromagnetic energy to an object housed in the HPP apparatus.

Claims

1. A hypothermic pulsatile perfusion (HPP) apparatus, comprising:

a chamber configured to house an organ;

one or more nuclear magnetic resonance (NMR) elements configured to facilitate performing a first magnetic resonance (MR) based analysis of the organ using frequencies falling within a spectral bound, the spectral bound being associated with NMR; and

one or more spectrum elements configured to facilitate performing a second, different analysis of the organ using a second set of frequencies falling outside of the spectral bound;

the apparatus being constructed from MR compatible, non-ferromagnetic materials.

2. The HPP apparatus of claim 1, the first analysis being one or more of, magnetic resonance spectroscopy (MRS), and magnetic resonance imaging (MRI).

3. The HPP apparatus of claim 1, the second analysis being one or more of, infrared imaging, optical coherence tomography (OCT), optical spectroscopy, reflectance, absorption spectroscopy, emission spectroscopy, laser-induced fluorescence, diffusive optical imaging, fluoroscopy, digital radiography, x-ray, microscopy, digital radiography, and photography.

4. The HPP apparatus of claim 1, the second analysis being an active operation comprising applying second electromagnetic energy to the organ and receiving spectrum data in response to applying the second electromagnetic energy to the organ.

5. The HPP apparatus of claim 4, the second set of frequencies being in one or more of, the far infrared range, the infrared range, the near infrared range, the visible range, the ultraviolet range, and x-ray range.

6. The HPP apparatus of claim 1, where the second analysis is a passive operation comprising receiving image data from the organ.

7. The HPP apparatus of claim 1, comprising:

a sterile, disposable inner liner configured to house the organ in the chamber.

8. The HPP apparatus of claim 7, the inner liner being configured to hold the organ in a substantially constant position and orientation with respect to one or more of, the NMR elements, and the spectrum elements.

9. The HPP apparatus of claim 7, the inner liner being configured to house the organ in a liquid solution.

10. The HPP apparatus of claim 1, the one or more spectrum elements comprising:

an optical probe configured to detect coherent light reflected from the organ, the optical probe being configured to facilitate performing one or more of, optical coherence tomography (OCT), and optical spectroscopy on the organ, the optical probe being constructed from MR compatible, non-ferromagnetic materials.

11. The HPP apparatus of claim 10, the optical probe being positioned to remain at least a predetermined distance away from the organ.

12. The HPP apparatus of claim 10, the optical probe being positioned to be placed within the organ for interstitial analysis.

13. The HPP apparatus of claim 1, comprising one or more of, an NMR test element configured to facilitate acquiring test data for assessing operation of the NMR elements, and a spectrum test element configured to facilitate acquiring test data for assessing operation of the spectrum elements.

14. The HPP apparatus of claim 1, the MR based analysis of the organ and the second analysis of the organ being configured to provide information concerning one or more of, mitochondrial function of the organ, ATP content of the organ, ADP content of the organ, NADH concentration in the organ, a ¹H peak, and a ³¹P peak.

15. The HPP apparatus of claim 1, the first analysis and the second analysis being configured to provide data concerning one or more of, perfusion, disease detection, and cancer detection.

16. The HPP apparatus of claim 1, comprising a communication apparatus configured to provide one or more of, raw data, viability data, and imagery.

17. The HPP of claim 16, the communication apparatus being one of, a cellular telephone communication apparatus, a telephone communication apparatus, and a computer networking apparatus.

18. The HPP of claim 16, the raw data, viability data, and imagery being suitable for display on one or more of, a cellular telephone with a graphic display, a personal computer, and a tablet computer.

19. A hypothermic pulsatile perfusion (HPP) apparatus, comprising:

an organ chamber configured to house an organ;

one or more optical elements configured to facilitate performing one or more of, optical coherence tomography (OCT), laser induced fluoroscopy, infrared imaging, and optical spectroscopy on the organ; and

an optical probe configured to detect coherent light reflected from the organ;

the HPP being constructed from MR compatible materials.

20. The HPP of claim 19, comprising one or more of, a camera, an infrared camera, a microscope, and a digital radiography apparatus.

21. The HPP of claim 20, comprising a viability logic configured to provide a signal concerning a change in the viability of the organ as a function of analyzing one or more of, the coherent light reflected from the organ, and an image acquired from one or more of, the camera, the infrared camera, the digital radiography apparatus, and the microscope.

22. The HPP apparatus of claim 19, where the optical probe is configured to facilitate performing one or more of, optical coherence tomography (OCT), and optical spectroscopy on the organ, the optical probe being constructed from MR compatible, non-ferromagnetic materials.

23. The HPP apparatus of claim 19, where the optical elements comprise:

a first fiber to deliver laser light, and

an excitation source;

and

where the optical probe comprises a second fiber to collect light from the organ.

24. The HPP apparatus of claim 23, where the first fiber and the second fiber are the same fiber.

25. An apparatus, comprising:

an NMR apparatus configured to apply a first energy to an object positioned in a perfusion apparatus, the first energy being produced in accordance with a nuclear magnetic resonance (NMR) pulse sequence designed to excite one or more nuclei in the object, the perfusion apparatus comprising an RF coil positioned and oriented to facilitate optimizing NMR spectroscopy of the object;

an optical apparatus configured to apply a second energy to the object positioned in the perfusion apparatus;

a spectra receiving apparatus configured to receive spectrum data from the object, the spectrum data being produced in response to applying at least one of, the first energy, and the second energy to the object; and

a data logic configured to provide objective, quantitative object viability data from the spectrum data.

26. The apparatus of claim 25, the second energy being in one or more of, the far infrared range, the infrared range, the near infrared range, the visible range, the ultraviolet range, and x-ray range.

27. The apparatus of claim 25, where the object viability data is processed as at least one of, an instantaneous measurement, a time series measurement, and a differential between multiple measurements, where the measurements concern one or more of, mitochondrial function of the organ, ATP content of the organ, ADP content of the organ, NADH concentration in the organ, a ¹H peak, and a ³¹P peak.

28. The apparatus of claim 25, where the data logic is configured to generate an image of at least a portion of the object from the spectrum data.

29. The apparatus of claim 25, where the data logic is configured to to generate an image of at least a portion of the object from the spectrum data and to generate at least one of, an instantaneous measurement, a time series, and a differential between multiple measurements.

30. The apparatus of claim 25, comprising at least one of, an NMR test element, and an optical test element, where the NMR test element is configured to facilitate monitoring whether the NMR apparatus is functioning correctly, and the optical test element is configured to facilitate monitoring whether the optical apparatus is functioning correctly.

31. The apparatus of claim 25, the object being one of, an animal tissue, a human tissue, an animal organ, and a human organ.

32. The apparatus of claim 25, where perfusion apparatus is one of, a pulsatile perfusion apparatus, and a hypothermic pulsatile perfusion apparatus.

33. The apparatus of claim 25, comprising a communication apparatus configured to provide one or more of, raw data, viability data, and imagery.

34. The apparatus of claim 33, the communication apparatus being one of, a cellular telephone communication apparatus, a telephone communication apparatus, and a computer networking apparatus.

35. The HPP of claim 33, the raw data, viability data, and imagery being suitable for display on one or more of, a cellular telephone with a graphic display, a personal computer, and a tablet computer.

36. An apparatus, comprising:

an optical apparatus configured to apply a first energy to an organ positioned in a pulsatile perfusion (PP) apparatus;

a spectra apparatus configured to receive spectrum data from the organ and to perform a first analysis, the spectrum data being produced in response to applying the first energy to the organ; and

a data logic configured to provide objective, quantitative organ viability data from the spectrum data.

37. The apparatus of claim 36, the first energy being in the near infrared range.

38. The apparatus of claim 36, the first energy being sufficient to generate an optical response in the organ.

39. The apparatus of claim 36, comprising:

a nuclear magnetic resonance (NMR) apparatus configured to facilitate performing a second analysis of the organ, where the NMR apparatus is configured to apply a second energy to the organ, the second analysis being one or more of, magnetic resonance spectroscopy (MRS), and magnetic resonance imaging (MRI); and

a spectrum apparatus configured to facilitate performing a third analysis of the organ, the third analysis being one or more of, optical coherence tomography (OCT), optical spectroscopy, diffusive optical imaging, digital radiography, microscopy, photography, and infrared imaging; and

where the spectra apparatus is configured to perform the first, second, and third analysis, and the apparatus is constructed from MR compatible, non-ferromagnetic materials.

40. A method, comprising:

controlling a dedicated NMR apparatus to apply NMR electromagnetic energy to an object housed in a perfusion apparatus;

acquiring NMR spectrum data from the object, the NMR spectrum data having been produced in response to applying the NMR electromagnetic energy;

controlling a dedicated non-NMR apparatus to apply non-NMR electromagnetic energy to the object;

acquiring non-NMR spectrum data from the object, the non-NMR spectrum data having been produced in response to applying the non-NMR electromagnetic energy;

computing a viability data from the NMR spectrum and the non-NMR spectrum data; and

providing the viability data.

41. The method of claim 40, the object being one of, an animal tissue, a human tissue, an animal organ, and a human organ and the viability data concerning one or more of, mitochondrial function of the organ, ATP content of the organ, ADP content of the organ, NADH concentration in the organ, a ¹H peak, and a ³¹P peak.

42. The method of claim 40, the dedicated non-NMR apparatus being one of, an optical coherence tomography (OCT) apparatus, and an optical spectroscopy apparatus.

43. A method, comprising:

controlling a dedicated NMR apparatus to apply NMR electromagnetic energy to an object housed in a perfusion apparatus;

acquiring NMR spectrum data from the object, the NMR spectrum data having been produced in response to applying the NMR electromagnetic energy;

controlling a photographic apparatus to acquire photographic data from the object;

computing a viability data from the NMR spectrum data and the photographic data; and

providing the viability data.

44. The method of claim 43, the object being one of, an animal tissue, a human tissue, an animal organ, and a human organ, the perfusion apparatus being one of, a pulsatile perfusion apparatus, and a hypothermic pulsatile perfusion apparatus, and the viability data concerning one or more of, mitochondrial function of the organ, ATP content of the organ, ADP content of the organ, NADH concentration in the organ, a ¹H peak, and a ³¹P peak.

45. A method, comprising:

controlling a photographic apparatus to acquire photographic data from an object housed in a perfusion apparatus;

computing viability data from the photographic data; and

providing the viability data.

46. The method of claim 45, the object being one of, an animal tissue, a human tissue, an animal organ, and a human organ, the perfusion apparatus being one of, a pulsatile perfusion apparatus, and a hypothermic pulsatile perfusion apparatus, and the viability data concerning one or more of, mitochondrial function of the organ, ATP content of the organ, ADP content of the organ, NADH concentration in the organ, a ¹H peak, and a ³¹P peak.

47. The method of claim 45, comprising:

controlling a dedicated non-NMR apparatus to apply non-NMR electromagnetic energy to the object, the dedicated non-NMR apparatus being one of, an optical coherence tomography (OCT) apparatus, and an optical spectroscopy apparatus;

acquiring non-NMR spectrum data from the object, the non-NMR spectrum data having been produced in response to applying the non-NMR electromagnetic energy to the object; and

computing viability data from the photographic data and the non-NMR data.