Determination of a Measure of a Glycation End-Product or Disease State Using Tissue Fluorescence of Various Sites
First Claim
1. An apparatus for the determination of the presence of diabetes, the presence of pre-diabetes, or a combination thereof, from spectral information collected from in vivo tissue of an individual, comprising:
- (a) an illumination system configured to provide light at a plurality of broadband ranges;
(b) an optical probe mounted with the illumination system such that the optical probe receives light from the illumination system, wherein the optical probe is configured to transmit at least a portion of said received light to in vivo tissue of the individual, and to receive light (i) diffusely reflected in response to the transmitted light, (ii) emitted from the in vivo tissue by fluorescence thereof in response to the transmitted light, or (iii) a combination thereof;
(c) a spectrograph, mounted in optical communication with the optical probe, configured to produce a signal representative of the spectral properties of the light received by the optical probe;
(d) an analysis system configured to determine the presence of diabetes, the presence of pre-diabetes, or a combination thereof from the signal from the spectrograph.
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Accused Products
Abstract
Embodiments of the present invention provide an apparatus suitable for determining properties of in vivo tissue. An illumination system communicates light at a plurality of broadband ranges to an optical probe, which can comprise a flexible probe. Light homogenizers and mode scramblers can be employed in some embodiments. The optical probe can physically contact the tissue, or can be maintained separate from the tissue. The optical probe receives light from the illumination system and transmits it to tissue, and receives light diffusely reflected in response to the broadband light, emitted from the in vivo tissue by fluorescence thereof in response to the broadband light, or a combination thereof. The optical probe can communicate the light to a spectrograph which produces a signal representative of the spectral properties of the light. An analysis system determines a property of the in vivo tissue from the spectral properties.
104 Citations
24 Claims
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1. An apparatus for the determination of the presence of diabetes, the presence of pre-diabetes, or a combination thereof, from spectral information collected from in vivo tissue of an individual, comprising:
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(a) an illumination system configured to provide light at a plurality of broadband ranges; (b) an optical probe mounted with the illumination system such that the optical probe receives light from the illumination system, wherein the optical probe is configured to transmit at least a portion of said received light to in vivo tissue of the individual, and to receive light (i) diffusely reflected in response to the transmitted light, (ii) emitted from the in vivo tissue by fluorescence thereof in response to the transmitted light, or (iii) a combination thereof; (c) a spectrograph, mounted in optical communication with the optical probe, configured to produce a signal representative of the spectral properties of the light received by the optical probe; (d) an analysis system configured to determine the presence of diabetes, the presence of pre-diabetes, or a combination thereof from the signal from the spectrograph. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24)
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Specification