APPARATUS FOR MEASURING A PROPAGATION VELOCITY OF A BLOOD PRESSURE WAVE

• US 20120179053A1
• Filed: 08/02/2010
• Published: 07/12/2012
• Est. Priority Date: 07/31/2009
• Status: Abandoned Application

• Current Assignee: CNR Dipartimento di Medicina, Fondazione Toscana Gabriele Monasterio
• Original Assignee: CNR Dipartimento di Medicina, Fondazione Toscana Gabriele Monasterio
• Inventors: Gemignani, Vincenzo, Faita, Francesco, Bianchini, Elisabetta
• Application Number:
  US13/388,098
• Publication Number:
  US 20120179053A1
• Time in Patent Office: Days
• US Class Current: 600/485
• CPC Class Codes: A61B 5/021 Measuring pressure in heart or blood vessels A61B5/0205 takes precedence
• CPC Class Codes: A61B 5/02125 of pulse wave propagation time
• CPC Class Codes: A61B 5/02133 by using induced vibration of the blood vessel
• CPC Class Codes: A61B 5/0285 Measuring or recording phase velocity of blood waves

Abstract

An apparatus for measuring the propagation velocity of a pressure wave comprises a first sensor of cutaneous vibration to measure a vibration generated in a first application point, creating a corresponding first signal, and a second sensor of cutaneous vibrations to measure a local cutaneous vibration generated in second point of an arterial vessel, creating a corresponding second signal caused by the deformation of the vessel responsive to the progression of the pressure wave in the vessel. A control unit detects on the first and second signal respectively a first instant time T1 and a second instant time T2 corresponding to a same event of a cardiac cycle. On the basis of T1 and T2 a transit time PTT (Pulse Transit Time) is calculated of the pressure wave and then the propagation velocity is measured of the pressure wave as the ratio between the length of the path arterial.

Claims

1. An apparatus for measuring the propagation velocity of a pressure wave in a cardiovascular system, in particular a pressure wave arterial system, said apparatus comprising:

a first sensor of cutaneous vibrations, which is adapted to be mounted at a first application point of said arterial system for measuring a first cutaneous vibration, said first sensor creating a corresponding first cutaneous vibration signal;

a second sensor of cutaneous vibrations that is adapted to be mounted at a second application point of said arterial system different from said first point for measuring a second cutaneous vibration, said second sensor creating a corresponding second cutaneous vibration signal;

a means for determining the distance between said first and said second application points;

a control unit, said control unit comprising;

a means for detecting said first and said second cutaneous vibration signals as input towards said control unit;

a program means for calculating the propagation velocity of said pressure wave responsive to said distance between said first and said second application points and to said first and second cutaneous vibration signals,

wherein said first and second sensors of cutaneous vibrations are adapted to measure vibrations set between 1 Hz and 20 KHz, in particular between 5 Hz and 80 Hz.

2. An apparatus, according to claim 1, wherein said first sensor is adapted to be arranged in a first application point of the central arterial system and that is located at the heart, in order to measure the cutaneous vibration generated by the heartbeat, whereas said second sensor is adapted to be arranged at a second application point which is at an arterial vessel at a distance from the heart, in order to measure the vibration caused by the deformation of the vessel responsive to the movement of said pressure wave.

3. An apparatus, according to claim 1, wherein said first sensor is adapted to be arranged in a first application point of the central arterial system and that is located at an arterial vessel at a distance from the heart, whereas said second sensor is adapted to be arranged at a second application point which is at the same arterial vessel at a predetermined distance from said first point, in order to measure a local cutaneous vibration by the deformation of the vessel in each of said points located on said same arterial vessel.

4. An apparatus, according to claim 1, wherein said program means is adapted to determine:

on said first cutaneous vibration signal a first instant time corresponding to a predetermined event of a cardiac cycle;

on said second cutaneous vibration signal a second instant time corresponding to the occurrence of the same event of the cardiac cycle as a local deformation of said arterial vessel;

a transit time of said pressure wave as a time period difference between said first and said second instant times;

said propagation velocity of said pressure wave as the ratio between the distance between the heart and the application point of said second sensor and said transit time.

5. An apparatus, according to claim 1, wherein said first and second sensors are selected from the group comprised of:

an accelerometer, a microphone, or an inertial sensor.

6. An apparatus, according to claim 1, wherein said first and second sensors of cutaneous vibrations are applied by means of sticking plasters or other adhesive means, in order to provide a light contact with the skin of the patient at said first and second application points.

7. An apparatus, according to claim 1, wherein said apparatus comprises acquisition means of an electrocardiographic signal, said electrocardiographic signal being used as synchronism time for determining said first and second instant times.

8. An apparatus, according to claim 1, wherein said first sensor for acquisition of the signal of the cutaneous vibrations generated by the heart is adapted to be located on the sternum whereas said second sensor for acquisition of the signal of the cutaneous vibrations generated by said arterial vessel is adapted to be located on the neck of the patient, in particular at the carotid artery.

9. An apparatus, according to claim 1, wherein said first instant time corresponds to closing the aortic valve whereas said second instant time corresponds to the “

Dicrotic Notch”

of the waveform of the vessel diameter vibration.

10. An apparatus, according to claim 1, wherein said first instant time corresponds to opening the aortic valve whereas said second instant time corresponds to start of a quick increase of the diameter, i.e. the wave trough.

11. An apparatus, according to claim 1, wherein said program means is adapted to cause:

in basal conditions delay time T₀ between a tone of said first signal and the corresponding tone of said second signal;

in post-basal conditions delay time T between a tone of said first signal and the corresponding tone of said second signal;

variation of transit time Δ

T as T-T₀.

variation of the propagation velocity of said pressure wave as the ratio between said distance of the arterial path comprised between the heart and the application point of said second sensor, and said variation of the transit time Δ

T of the pressure wave.