DRUG CORES FOR SUSTAINED RELEASE OF THERAPEUTIC AGENTS
4 Assignments
0 Petitions
Accused Products
Abstract
A solid drug core insert can be manufactured by injecting a liquid mixture comprising a therapeutic agent and a matrix precursor into a sheath body. The injection can be conducted at subambient temperatures. The mixture is cured to form a solid drug-matrix core. The therapeutic agent can be a liquid at about room temperature that forms a dispersion of droplets in the matrix material. A surface of the solid drug core is exposed, for example by cutting the tube, and the exposed surface of the solid drug core releases therapeutic quantities of the therapeutic agent when implanted into the patient. In some embodiments, the insert body inhibits release of the therapeutic agent, for example with a material substantially impermeable to the therapeutic agent, such that the therapeutic quantities are released through the exposed surface, thereby avoiding release of the therapeutic agent to non-target tissues.
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Citations
76 Claims
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1-29. -29. (canceled)
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30. A method of manufacturing a drug insert for an implant body adapted for disposition within or adjacent to a body cavity, tissue, duct or fluid of a patient,
the method comprising injecting into a precursor sheath body, at an extrusion temperature of less than about 25° - C., a mixture comprising a therapeutic agent and a silicone matrix such that the precursor sheath body is substantially filled therewith, the precursor sheath body being substantially impermeable to the agent,
curing the mixture, at a curing temperature greater than about 25°
C., in the precursor sheath body to provide a cured, filled precursor sheath body containing a precursor drug core; anddividing the cured filled precursor sheath body to form a plurality of drug inserts. - View Dependent Claims (31, 33, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75)
- C., a mixture comprising a therapeutic agent and a silicone matrix such that the precursor sheath body is substantially filled therewith, the precursor sheath body being substantially impermeable to the agent,
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32. (canceled)
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34-41. -41. (canceled)
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76. A method for manufacturing a punctual plug, the method comprising;
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injecting into a precursor sheath body, at an extrusion temperature of less than about 25°
C., a mixture comprising a therapeutic agent and a silicone matrix such that the precursor sheath body is substantially filled therewith, the precursor sheath body being substantially impermeable to the agent,curing the mixture, at a curing temperature greater than about 25°
C., in the precursor sheath body to provide a cured, filled precursor sheath body containing a precursor drug core;dividing the cured filled precursor sheath to form a plurality of drug inserts; sealing each drug insert at one end of the drug insert; and inserting each drug insert into a channel of an implant body adapted to receive the insert therein.
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Specification