ANTI-IL-6 ANTIBODIES FOR THE TREATMENT OF ORAL MUCOSITIS
First Claim
Patent Images
1. A method of treating or preventing mucositis comprising administration of a composition comprising an effective amount of an IL-6 antagonist.
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0 Petitions
Accused Products
Abstract
The present invention is directed to therapeutic methods using IL-6 antagonists such as anti-IL-6 antibodies and fragments thereof having binding specificity for IL-6 to prevent or treat mucositis (e.g., oral mucositis) including persons on a treatment regimen with a drug or chemotherapy and/or radiation for cancer (e.g., head and neck cancer) that is associated with increased risk of mucositis, including oral mucositis.
47 Citations
194 Claims
- 1. A method of treating or preventing mucositis comprising administration of a composition comprising an effective amount of an IL-6 antagonist.
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- 21. A method of treating or preventing diarrhea comprising administration of a composition comprising an effective amount of an IL-6 antagonist.
- 25. A method of treating or preventing emesis comprising administration of a composition comprising an effective amount of an IL-6 antagonist.
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193. A method for the treating oral mucositis in a subject with head and neck cancer receiving concomitant chemotherapy comprising administering an effective amount of a humanized monoclonal antibody that selectively binds IL-6, wherein said antibody is Ab1.
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Specification