Skincare Compositions

• US 20120189684A1
• Filed: 07/19/2010
• Published: 07/26/2012
• Est. Priority Date: 07/17/2009
• Status: Active Grant

• Current Assignee: Reckitt Benckiser Incorporated (Reckitt Benckiser Group PLC)
• Original Assignee: Reckitt Benckiser Incorporated (Reckitt Benckiser Group PLC)
• Inventors: Buckley, Carolyn, Jackson, Stuart, Kilcullen, Neil, Pavis, Diane Marie
• Granted Patent: US 10,065,052 B2
• Time in Patent Office: Days
• US Class Current: 424/443
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 2800/28 Rubbing or scrubbing compositions; Peeling or abrasive compositions; Containing exfoliants
• CPC Class Codes: A61K 31/045 Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
• CPC Class Codes: A61K 31/19 Carboxylic acids, e.g. valproic acid salicylic acid A61K31/60
• CPC Class Codes: A61K 31/4166 having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
• CPC Class Codes: A61K 31/60 Salicylic acid; Derivatives thereof
• CPC Class Codes: A61K 36/185 Magnoliopsida (dicotyledons)
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61K 8/0208 Tissues; Wipes; Patches
• CPC Class Codes: A61K 8/34 Alcohols
• CPC Class Codes: A61K 8/365 Hydroxycarboxylic acids; Ketocarboxylic acids
• CPC Class Codes: A61K 8/368 with carboxyl groups directly bound to carbon atoms of aromatic rings
• CPC Class Codes: A61K 8/442 substituted by amido group(s)
• CPC Class Codes: A61K 8/4913 having five membered rings, e.g. pyrrolidone carboxylic acid
• CPC Class Codes: A61K 8/4946 Imidazoles or their condensed derivatives, e.g. benzimidazoles
• CPC Class Codes: A61K 8/602 Glycosides, e.g. rutin
• CPC Class Codes: A61K 8/63 Steroids; Derivatives thereof
• CPC Class Codes: A61K 8/675 Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde tocopheryl nicotinate A61K8/678
• CPC Class Codes: A61K 8/9789 Magnoliopsida [dicotyledons]
• CPC Class Codes: A61K 9/0014 Skin, i.e. galenical aspects of topical compositions non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00
• CPC Class Codes: A61P 17/10 : Anti-acne agents
• CPC Class Codes: A61P 29/00 : Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: A61P 31/00 : Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
• CPC Class Codes: A61P 31/04 : Antibacterial agents
• CPC Class Codes: A61P 31/10 : Antimycotics
• CPC Class Codes: A61P 31/12 : Antivirals
• CPC Class Codes: A61Q 19/00 : Preparations for care of the skin
• CPC Class Codes: A61Q 19/008 : Preparations for oily skin

Abstract

This invention relates to skincare compositions, in particular compositions effective in the treatment of acne vulgaris, and to methods of treatment of the skin that involve the application of such compositions, wherein the compositions comprise salicylic acid or a salt thereof in combination with at 2 actives selected from the group consisting of lactic acid or a salt thereof; glycyrrhizinic acid or a salt or derivative thereof; bisabolol; cetylhydroxyproline palmitamide; allantoin; niacinamide; and epilobium angustifolium extract.

Claims

1. A skincare composition suitable for topical application to the skin, the composition comprising keratolytic agent in combination with at least two actives selected from the group consisting of;

lactic acid or a salt thereof;

glycyrrhizinic acid or a salt or derivative thereof;

bisabolol;

cetylhydroxyproline palmitamide;

allantoin;

niacinamide; and

,

epilobium angustifolium extract.

2. A composition as claimed in claim 1, wherein the keratolytic agent comprises salicylic acid.

3. A composition as claimed in claim 2, wherein the concentration of salicylic acid is at least 0.01 percent by weight.

4. A composition as claimed in claim 2, wherein the concentration of salicylic acid is less than 10 percent by weight.

5. A composition according to claim 1, wherein one of the actives comprises lactic acid or a salt thereof in the concentration of at least 0.01 percent by weight.

6. A composition as claimed in claim 5, wherein the concentration of lactic acid or a salt thereof is less than 10 percent by weight.

7. A composition as claimed in claim 1, wherein one of the actives comprises glycyrrhizinic acid or a salt or derivative thereof in the concentration of at least 0.01 percent by weight.

8. A composition as claimed in claim 7, wherein the concentration of glycyrrhizinic acid or a salt or derivative thereof is less than 2 percent by weight.

9. A composition as claimed in claim 1, wherein one of the actives comprises bisabolol in the concentration of bisabolol is at least 0.001 percent by weight.

10. A composition as claimed in claim 9, wherein the concentration of bisabolol is less than 1 percent by weight.

11. A composition as claimed in claim 1, wherein one of the actives comprises cetylhydroxyproline palmitamide in the concentration of at least 0.001 percent by weight.

12. A composition as claimed in claim 11, wherein the concentration of cetylhydroxyproline palmitamide is less than 1 percent by weight.

13. A composition as claimed in claim 1, wherein one of the actives comprises allantoin in the concentration at least 0.01 percent by weight.

14. A composition as claimed in claim 13, wherein the concentration of allantoin is less than 5 percent by weight.

15. A composition as claimed in claim 1, wherein one of the actives comprises niacinamide in the concentration of at least 0.01 percent by weight.

16. A composition as claimed in claim 15, wherein the concentration of niacinamide is less than 10 percent by weight.

17. A composition as claimed in claim 1, wherein one of the actives comprises epilobium angustifolium in the concentration of at least 0.001 percent by weight.

18. A composition as claimed in claim 17, wherein the concentration of epilobium angustifolium is less than 1 percent by weight.

19. A skincare composition according to claim 1, wherein the keratolytic agent comprises 0.1 to 5 wt % salicylic acid or a salt thereof, and the at least two actives are selected from the group consisting of:

0.1 to 5 wt % lactic acid or a salt thereof;

0.01 to 1 wt % glycyrrhizinic acid or a salt or derivative;

0.001 to 1 wt % bisabolol;

0.001 to 1 wt % cetylhydroxyproline palmitamide

0.1 to 2 wt % allantoin;

0.1 to 5 wt % niacinamide; and

,

0.001 to 1% epilobium angustifolium extract.

20. A skincare composition according to claim 1, wherein the keratolytic agent comprises 1 to 3 wt % salicylic acid or a salt thereof, and the at least two actives are selected from the group consisting of:

1 to 3 wt % lactic acid or a salt thereof;

0.01 to 0.5 wt % glycyrrhizinic acid or a salt or derivative thereof;

0.02 to 0.5 wt % bisabolol;

0.01 to 0.5 wt % cetylhydroxyproline palmitamide;

0.2 to 1 wt % allantoin;

0.5 to 5 wt % niacinamide; and

,

0.01 to 0.5% epilobium angustifolium extract.

21. A composition as claimed in claim 1 wherein the pH is in the range from 3.5 to 6.0.

22. A composition as claimed in claim 1 further comprising one or more further topically active skincare agents selected from the group consisting of an antimicrobial or anti-bacterial compound, an anti-viral compound, an anti-fungal compound, an anti-inflammatory compound and an anthelmintic compound.

23. A composition as claimed in claim 1 having the form of one of an aqueous solution surfactant wash, an oily solution surfactant wash, a dispersion, an emulsion, or a gel.

25. A composition as claimed in claim 23 having the form of an emulsion comprising an oil-in-water emulsion.

26. A composition as claimed in claim 23 having the form of a gel comprising an aqueous gel.

27. A composition as claimed in claim 1 further comprising one or both of a gelling agent and a thickening agent.

28. A composition as claimed in claim 1 further comprising an aqueous solvent system.

29. A composition as claimed in claim 28, wherein the aqueous solvent system is a mixed solvent system comprising water in admixture with a co-solvent.

30. A composition as claimed in claim 29, wherein the co-solvent is an alcohol.

31. A composition as claimed in claim 1 further comprising one or more excipients selected from the group consisting of emulsifiers, emollients, lipids, humectants, moisturizers, binders, conditioning agents, emulsion stabilizing salts, preservatives, chelating agents, sequestering agents, abrasives, pH adjusters, surfactants, perfumes and colorings.

32. An article comprising a fibrous substrate impregnated with a skincare composition according to claim 1.

33. An article as claimed in claim 32, the fibrous substrate selected from the group consisting of cellulose fibers, cotton fibers, and a mixture thereof.

34. A method for the prophylactic or remedial treatment of acne comprising the topical application to the skin of a patient of the skincare composition according to claim 1.

35. A method as claimed in claim 34, which is a cosmetic method.

36. A method as claimed in claim 34, which is a therapeutic method.

37. The use of the composition according to claim 1 in a composition for the prophylactic or remedial treatment of acne by topical application of the composition to the skin.

40. A composition as claimed in claim 23 having the form of an emulsion selected from the group consisting of an oil-in-water emulsion, a water-in-oil emulsion, and a microemulsion.

24. (canceled)

38. A method for reducing irritancy associated with the topical application of a skincare composition comprising salicylic acid in combination with at two actives selected from the group consisting of lactic acid or a salt thereof;

glycyrrhizinic acid or a salt or derivative thereof;

bisabolol;

cetylhydroxyproline palmitamide;

allantoin;

niacinamide;

and epilobium angustifolium extract.

39. A cosmetic method for improving the appearance of skin afflicted by acne lesions, comprising reducing the redness of lesions by the topical application of a skincare composition comprising salicylic acid in combination with at least two actives selected from the group consisting of:

lactic acid or a salt thereof;

glycyrrhizinic acid or a salt or derivative thereof;

bisabolol;

cetylhydroxyproline palmitamide;

allantoin;

niacinamide; and

epilobium angustifolium extract.