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METHOD FOR COMBINED IMAGING AND TREATING ORGANS AND TISSUES

  • US 20120190925A1
  • Filed: 01/25/2012
  • Published: 07/26/2012
  • Est. Priority Date: 01/25/2011
  • Status: Abandoned Application
First Claim
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1. A method for in vivo diagnosis, visualization or therapy of residual diseased tissue in a subject in need thereof comprising:

  • (a) illuminating an in vivo exposed body cavity, integument, or organ of a subject containing diseased tissue with light having at least one excitation wavelength in the range from about 401 nm to about 510 nm;

    (b) directly viewing the illuminated cavity, integument, or organ with or without the aid of an endoscope fluorescence emitted from the body cavity or organ in response to the light from a fluorescent targeting construct comprising a fluorophore-tagged tumor-specific antibody or a fluorophore-tagged tumor avid moiety and a therapeutic isotope molecule, wherein the fluorophore-tagged antibody or fluorophore-tagged tumor avid moiety is responsive to the excitation wavelength administered to the subject and which has specifically bound to and/or been taken up by the diseased tissue in the exposed body cavity or organ; and

    (c) determining by direct visualization without the aid of a capture device the location and/or surface area of the diseased tissue in the subject from the fluorescence provided by the targeting construct.

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