METHOD AND APPARATUS FOR IN VIVO SURVEILLANCE OF CIRCULATING BIOLOGICAL COMPONENTS
First Claim
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1. A method for collecting markers associated with circulating cells, comprising the steps of:
- providing a probe comprising a metallic guidewire comprising a binding surface and an atraumatic distal tip, wherein the binding surface comprises an outer nanostructured polymer zone and an inner non-porous zone, wherein the nanostructured polymer zone has affixed thereto at least one binding partner for binding a marker, and wherein the nanostructured polymer zone is configured to immobilize a marker to the binding surface upon binding of the marker to the binding partner, thereby increasing the surface area of the binding surface;
positioning at least a portion of the probe in an anatomical structure of a living organism;
maintaining the probe in a generally fixed position for greater than 1 hour; and
removing the probe from the living organism.
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Abstract
The invention relates generally to in vivo collection of circulating molecules, tumor cells and other biological markers using a collecting probe. The probe is configured for placement within a living organism for an extended period of time to provide sufficient yield of biological marker for analysis.
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Citations
20 Claims
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1. A method for collecting markers associated with circulating cells, comprising the steps of:
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providing a probe comprising a metallic guidewire comprising a binding surface and an atraumatic distal tip, wherein the binding surface comprises an outer nanostructured polymer zone and an inner non-porous zone, wherein the nanostructured polymer zone has affixed thereto at least one binding partner for binding a marker, and wherein the nanostructured polymer zone is configured to immobilize a marker to the binding surface upon binding of the marker to the binding partner, thereby increasing the surface area of the binding surface; positioning at least a portion of the probe in an anatomical structure of a living organism; maintaining the probe in a generally fixed position for greater than 1 hour; and removing the probe from the living organism. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18)
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19. A method for collecting markers associated with circulating cells, comprising the steps of:
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providing a guidewire comprising a binding surface and an atraumatic distal tip, wherein the binding surface comprises an outer nanostructured polymer zone and an inner non-porous zone, wherein the nanostructured polymer zone has affixed thereto at least one binding partner for binding a marker, and wherein the nanostructured polymer zone is configured to immobilize a marker to the binding surface upon binding of the marker to the binding partner, thereby increasing the surface area of the binding surface; positioning at least a portion of the guidewire in an anatomical structure of a living organism; maintaining the guidewire in a generally fixed position for greater than 1 hour; and removing the guidewire from the living organism.
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20. A system for collecting markers associated with circulating cells, comprising:
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a probe comprising a guidewire comprising a binding surface and an atraumatic distal tip, wherein the binding surface comprises an outer nanostructured polymer zone and an inner non-porous zone, wherein the nanostructured polymer zone has affixed thereto at least one binding partner for binding a marker, and wherein the nanostructured polymer zone is configured to immobilize a marker to the binding surface upon binding of the marker to the binding partner, thereby increasing the surface area of the binding surface; wherein at least a portion of the guidewire is configured to be placed within an anatomical structure of a living organism.
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Specification