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METHOD AND APPARATUS FOR IN VIVO SURVEILLANCE OF CIRCULATING BIOLOGICAL COMPONENTS

  • US 20120191009A1
  • Filed: 12/21/2011
  • Published: 07/26/2012
  • Est. Priority Date: 12/22/2003
  • Status: Active Grant
First Claim
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1. A method for collecting markers associated with circulating cells, comprising the steps of:

  • providing a probe comprising a metallic guidewire comprising a binding surface and an atraumatic distal tip, wherein the binding surface comprises an outer nanostructured polymer zone and an inner non-porous zone, wherein the nanostructured polymer zone has affixed thereto at least one binding partner for binding a marker, and wherein the nanostructured polymer zone is configured to immobilize a marker to the binding surface upon binding of the marker to the binding partner, thereby increasing the surface area of the binding surface;

    positioning at least a portion of the probe in an anatomical structure of a living organism;

    maintaining the probe in a generally fixed position for greater than 1 hour; and

    removing the probe from the living organism.

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