CALIBRATION METHOD FOR THE PROSPECTIVE CALIBRATION OF MEASURING EQUIPMENT
First Claim
1. A method for operating measuring equipment for detecting at least one analyte in a bodily fluid with a continuously monitoring sensor, the method comprising:
- detecting at least three calibration points, each calibration point comprising a measurement signal from the measuring equipment and a reference value of an associated reference measurement, wherein the reference value corresponds to an actual present value of concentration of the analyte in the bodily fluid;
establishing a plurality of possible slopes between the calibration points;
using a robust estimation method to determine a probable slope from the plurality of possible slopes, the robust estimation method comprising a statistical estimation method which supplies stable statistical estimators even if outliers occur or if distribution assumptions are only approximately valid, the robust estimation being based on one or more permutation algorithms and/or on one or more sorting algorithms; and
performing at least one measurement in which the probable slope is used with the measurement equipment to determine a concentration of the analyte in the bodily fluid.
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Accused Products
Abstract
A method for operating measuring equipment for detecting an analyte in a bodily fluid by means of a continuously measuring blood glucose sensor. A calibration method is carried out for the prospective calibration of the measuring equipment. At least three calibration points are detected in the calibration method, wherein each calibration point comprises a measurement signal from the measuring equipment and a reference value of an associated reference measurement. A plurality of possible slopes are established between the calibration points. At least one robust estimation method, using a formation of at least one median is used to determine a probable slope from the plurality of possible slopes. Furthermore, a measurement is carried out. During the measurement and using the probable slope, a concentration of the analyte in the bodily fluid is deduced from a measurement signal from the measuring equipment and the probable slope.
13 Citations
20 Claims
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1. A method for operating measuring equipment for detecting at least one analyte in a bodily fluid with a continuously monitoring sensor, the method comprising:
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detecting at least three calibration points, each calibration point comprising a measurement signal from the measuring equipment and a reference value of an associated reference measurement, wherein the reference value corresponds to an actual present value of concentration of the analyte in the bodily fluid; establishing a plurality of possible slopes between the calibration points; using a robust estimation method to determine a probable slope from the plurality of possible slopes, the robust estimation method comprising a statistical estimation method which supplies stable statistical estimators even if outliers occur or if distribution assumptions are only approximately valid, the robust estimation being based on one or more permutation algorithms and/or on one or more sorting algorithms; and performing at least one measurement in which the probable slope is used with the measurement equipment to determine a concentration of the analyte in the bodily fluid. - View Dependent Claims (2, 3, 4, 5, 6, 7, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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8. The method of claim 8, wherein the user is invited to carry out the calibration method if at least one current measurement signal lies in a region in which the calibration method was not yet carried out with sufficient calibration quality.
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18. A computer readable storage medium storing one or more programs, the one or more programs comprising instructions, which when executed by a computer of measuring equipment for detecting an analyte in a bodily fluid, cause the computer to perform a method comprising the following steps:
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detecting at least three calibration points, each calibration point comprising a measurement signal from the measuring equipment and a reference value of an associated reference measurement, wherein the reference value corresponds to an actual present value of concentration of the analyte in the bodily fluid; establishing a plurality of possible slopes between the calibration points; using a robust estimation method to determine a probable slope from the plurality of possible slopes, the robust estimation method comprising a statistical estimation method which supplies stable statistical estimators even if outliers occur or if distribution assumptions are only approximately valid, the robust estimation being based on one or more permutation algorithms and/or on one or more sorting algorithms; and performing at least one measurement in which the probable slope is used with the measurement equipment to determine a concentration of the analyte in the bodily fluid.
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19. Measuring equipment for detecting at least one analyte in a bodily fluid, comprising:
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a continuously measuring bodily fluid analyte sensor; a processor having a program stored in memory and configured for execution by the processor, the program including instructions for; detecting at least three calibration points, each calibration point comprising a measurement signal from the measuring equipment and a reference value of an associated reference measurement, wherein the reference value corresponds to an actual present value of concentration of the analyte in the bodily fluid; establishing a plurality of possible slopes between the calibration points; using a robust estimation method to determine a probable slope from the plurality of possible slopes, the robust estimation method comprising a statistical estimation method which supplies stable statistical estimators even if outliers occur or if distribution assumptions are only approximately valid, the robust estimation being based on one or more permutation algorithms and/or on one or more sorting algorithms; and performing at least one measurement in which the probable slope is used with the measurement equipment to determine a concentration of the analyte in the bodily fluid. - View Dependent Claims (20)
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Specification