CARRIER IMMUNOGLOBULINS AND USES THEREOF
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Abstract
Disclosed is an isolated antigen binding protein, such as but not limited to, an antibody or antibody fragment. Also disclosed are pharmaceutical compositions and medicaments comprising the antigen binding protein, isolated nucleic acid encoding it, vectors, host cells, and hybridomas useful in methods of making it. In some embodiments the antigen binding protein comprises one to twenty-four pharmacologically active chemical moieties conjugated thereto, such as a pharmacologically active polypeptide.
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Citations
118 Claims
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1-60. -60. (canceled)
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61. An isolated antigen binding protein, comprising an immunoglobulin heavy chain variable region and an immunoglobulin light chain variable region, wherein the heavy chain variable region comprises an amino acid sequence at least 95% identical to the sequence of SEQ ID NO:
- 250, SEQ ID NO;
252, SEQ ID NO;
254, SEQ ID NO;
256, SEQ ID NO;
258, or SEQ ID NO;
260. - View Dependent Claims (62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89)
- 250, SEQ ID NO;
- 90. An isolated antigen binding protein, comprising an immunoglobulin heavy chain variable region and an immunoglobulin light chain variable region, wherein the heavy chain variable region comprises an amino acid sequence at least 95% identical to the sequence of SEQ ID NO:
Specification