SUBSTITUTED POLYALKOXYSILOXANE COMPOSITIONS AND METHODS OF USE

• US 20120196832A1
• Filed: 04/13/2012
• Published: 08/02/2012
• Est. Priority Date: 10/04/2006
• Status: Active Grant

• Current Assignee: One Unlimited Incorporated
• Original Assignee: One Unlimited Incorporated
• Inventors: LURIA, LEONARD WILLIAM
• Granted Patent: US 8,552,135 B2
• Time in Patent Office: Days
• US Class Current: 514/63
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61P 17/02 for treating wounds, ulcers, burns, scars, keloids, or the like
• CPC Class Codes: A61P 17/10 Anti-acne agents
• CPC Class Codes: C07F 7/0838 Compounds with one or more Si-O-Si sequences compounds with a ring containing only alternating Si and O atoms, i.e. cyclosilanes C07F7/21
• CPC Class Codes: C07F 7/0876 Reactions involving the formation of bonds to a Si atom of a Si-O-Si sequence other than a bond of the Si-O-Si linkage
• CPC Class Codes: C08G 77/045 containing less than 25 silicon atoms
• CPC Class Codes: C08G 77/16 to hydroxyl groups
• CPC Class Codes: C08G 77/38 Polysiloxanes modified by chemical after-treatment C08G77/045 takes precedence
• CPC Class Codes: C09D 183/04 Polysiloxanes
• CPC Class Codes: Y10T 428/31612 As silicone, silane or siloxane

Abstract

Linear polydialkoxysiloxanes with 2-8 polymeric units have been reacted with alcohols by a transetherification reaction to provide hydrophilic and water soluble silicone products. The glycerol substituted siloxanes in particular are effective in topically treating skin lesions such as radiation burns. Compositions including the substituted polydialkoxysiloxane products inhibit biofilm formation when used as coatings on hard surfaces.

Claims

1. A composition comprising a linear polydialkoxy siloxane having 2-15 silicone polymer units wherein one or more alkoxy groups on the siloxane backbone is replaced with an alcohol.

2. The composition of claim 1 wherein the alkoxy groups are ethoxy or methoxy.

3. The composition of claim 1 wherein 30-60% of the alkoxy groups are replaced with the alcohol.

5. The composition of claim 1 wherein the alcohol is 1-propanol, 2-propanol, 1-butanol, 1-pentanol, 1-hexanol, 1,2-propane diol, 1,3-propane diol, 1,6-hexane diol, glycerol or propylene glycol.

6. The composition of claim 1 wherein the alcohol is BRONOPOL or glycerol.

7. The composition of claim 1 which comprises a compound having the structure:

8. The composition of claim 1 wherein the composition comprises a polysiloxane having the structure:

9. The composition of claim 2 comprised within a pharmaceutically acceptable carrier.

10. A method for treatment or prevention of skin lesions in a mammal in need thereof, comprising administering to said mammal an effective amount of the composition of claim 2.

11. The method of claim 10 wherein the composition comprises a compound having the structure:

12. The method of claim 10 wherein the skin lesion is topical dermatitis, rosacea, acne, scarring, cold sore, skin rash, or mechanical or actinic skin damage.

13. The method of claim 10 wherein the skin lesion is a radiation burn.

14. A kit for treatment of skin lesions, comprising:

the composition of claim 1; and

an excipient or carrier suitable for mixing with said substituted polydialkoxysiloxane suitable to provide a topical formulation.

15. The kit of claim 14 wherein the composition includes a compound with the structure of claim 7 wherein n is 2-4 and glycerol replaces up to about 30-50% of the ethoxy groups.

16. The kit of claim 14 wherein the skin lesion is topical dermatitis, rosacea, acne, scarring, cold sore, skin rash, or mechanical or actinic skin damage.

17. The kit of claim 14 wherein the skin lesion is a radiation burn.

18. A method for inhibiting biofilm formation on a surface, comprising, contacting a solid surface with a 0.25%-8% by volume solution comprising the composition of claim 1 with a solid surface to provide a coating resistant to biofilm formation.

19. The method of claim 18 where the solid surface is within an aqueous medium.

20. The method of claim 18 wherein the solid surface is glass, ceramic, plastic, metal or polymer.

21. The method of claim 18 wherein the solid surface is a live fish or plant in the aqueous medium.

22. The method of claim 18 wherein the biofilm is algal or bacterial.

23. The method of claim 22 wherein the bacterial biofilm is produced by Pseudomonas or Staphylococcus aureus.

4. The composition of claim further comprising non-linear polydialkoxy siloxanes having one or more alkoxy groups replaced with an alcohol.