METHOD FOR TREATING PSORIASIS

• US 20120202878A1
• Filed: 01/17/2012
• Published: 08/09/2012
• Est. Priority Date: 02/08/2011
• Status: Active Grant

• Current Assignee: The William M. Yarbrough Foundation
• Original Assignee: The William M. Yarbrough Foundation
• Inventors: Silver, Michael E.
• Granted Patent: US 9,532,969 B2
• Time in Patent Office: Days
• US Class Current: 514/514
• CPC Class Codes: A61K 31/26 Cyanate or isocyanate esters; Thiocyanate or isothiocyanate esters
• CPC Class Codes: A61K 47/542 Carboxylic acids, e.g. a fatty acid or an amino acid
• CPC Class Codes: A61P 17/06 Antipsoriatics

Abstract

A method for treating psoriasis including the steps of applying an isothiocyanate functional surfactant to an area affected by psoriasis, wherein the isothiocyanate functional surfactant comprises at least one isothiocyanate functional group associated with an aliphatic and/or aromatic carbon atom of the isothiocyanate functional surfactant.

Claims

1. A method for treating psoriasis, comprising the step(s) of:

applying an isothiocyanate functional surfactant to an area affected by psoriasis, wherein the isothiocyanate functional surfactant comprises at least one isothiocyanate functional group associated with an aliphatic and/or aromatic carbon atom of the isothiocyanate functional surfactant.

2. The method for treating psoriasis according to claim 1, further comprising the step of removing the isothiocyanate functional surfactant from the area affected by psoriasis.

11. The method for treating psoriasis, according to any one of claims 1 to 10, further comprising the step of applying an additional surfactant, wherein the additional surfactant is selected from at least one of the group comprising a non-ionic surfactant, an anionic surfactant, a cationic surfactant, a zwitterionic surfactant, and combinations thereof.

12. The method for treating psoriasis, according to any one of claims 1 to 11, wherein the psoriasis is selected from one of the groups comprising plaque psoriasis, guttate psoriasis, inverse psoriasis, pustular psoriasis, erythrodermic psoriasis, scalp psoriasis, and/or nail psoriasis.

3. A method for treating psoriasis, comprising the steps of:

applying an isothiocyanate functional surfactant to an area affected by psoriasis, wherein the isothiocyanate functional surfactant comprises at least one isothiocyanate functional group associated with an aliphatic and/or aromatic carbon atom of the isothiocyanate functional surfactant;

removing the isothiocyanate functional surfactant from the area affected by psoriasis; and

repeating the steps of applying and removing the isothiocyanate functional surfactant to/from the affected area.

4. A method for treating psoriasis, comprising the steps of:

washing an area affected by psoriasis with an isothiocyanate functional surfactant, wherein the isothiocyanate functional surfactant comprises at least one isothiocyanate functional group associated with an aliphatic and/or aromatic carbon atom of the isothiocyanate functional surfactant.

5. A method for treating psoriasis, comprising the step(s) of:

applying a lysine derivative to an area affected by psoriasis, wherein the lysine derivative comprises an α

-nitrogen and a ε

-nitrogen, and wherein an alkyl and/or alkanoyl substituent comprising at least approximately 8 carbon atoms is associated with the α

-nitrogen, and further wherein at least one isothiocyanate functional group is associated with the ε

-nitrogen.

6. A method for treating psoriasis, comprising the step(s) of:

applying a surfactant to an area affected by psoriasis, wherein the protonated form of the surfactant is represented by the following chemical structure;

7. A method for treating psoriasis, comprising the step(s) of:

applying a surfactant or a pharmaceutically acceptable salt thereof to an area affected by psoriasis, wherein the protonated form of the surfactant is represented by the following chemical structure;

8. A method for treating psoriasis, comprising the step(s) of:

applying a surfactant or a pharmaceutically acceptable salt thereof to an area affected by psoriasis, wherein the protonated form of the surfactant is represented by the following chemical structure;

9. A method for treating psoriasis, comprising the step(s) of:

applying a surfactant or a pharmaceutically acceptable salt thereof to an area affected by psoriasis, wherein the protonated form of the surfactant is represented by the following chemical structure;

10. A method for treating psoriasis, comprising the step(s) of:

applying a surfactant or a pharmaceutically acceptable salt thereof to an area affected by psoriasis, wherein the surfactant is represented by the following chemical structure;