IMPLANTS FOR REDUCING INTRAOCULAR PRESSURE

• US 20120203160A1
• Filed: 10/12/2010
• Published: 08/09/2012
• Est. Priority Date: 10/12/2009
• Status: Abandoned Application

• Current Assignee: The Board of Regents of the University of Colorado (University of Colorado System)
• Original Assignee: The Board of Regents of the University of Colorado (University of Colorado System)
• Inventors: Kahook, Malik Y., Mandava, Naresh, Shandas, Robin, Rech, Bryan
• Application Number:
  US13/501,599
• Publication Number:
  US 20120203160A1
• Time in Patent Office: Days
• US Class Current: 604/8
• CPC Class Codes: A61F 9/00781 Apparatus for modifying intraocular pressure, e.g. for glaucoma treatment drainage implants in general A61M27/002
• CPC Class Codes: A61K 9/0051 Ocular inserts, ocular implants
• CPC Class Codes: A61L 2400/16 Materials with shape-memory or superelastic properties
• CPC Class Codes: A61L 2430/16 for reconstruction of eye parts, e.g. intraocular lens, cornea
• CPC Class Codes: C08L 2201/12 Shape memory

Abstract

The present invention provides ocular implants adapted to reside in Schlemm'"'"'s canal for reducing intraocular pressure of an eye and methods for using the same. In some embodiments the ocular implants comprise a thin rod adapted and configured to extend in a curved volume in Schlemm'"'"'s canal. The thin rod comprises a plurality of wave-shaped segments such that a sufficient number and amount of wave-shaped segments extend to the inner wall of the trabecular meshwork and to the outer wall of Schlemm'"'"'s canal thereby keeping Schlemm'"'"'s canal open.

Claims

1. An ocular implant adapted and configured to reside completely within Schlemm'"'"'s canal of an eye, wherein when implanted within Schlemm'"'"'s canal said implant conforms to the inner lumen of Schlemm'"'"'s canal and comprises a thin rod adapted and configured to extend in a curved volume whose longitudinal axis defines a plane when said rod resides in Schlemm'"'"'s canal of the eye and wherein said thin rod comprises a plurality of wave-shaped segments, a diameter in the range of about 5 to about 400 μ

m, a total length in the range of from about 0.5 to about 40 mm, a sufficient amount of tensile strength, and a sufficient number and amount of wave-shaped segments that extend to the outer wall of the trabecular meshwork and to the outer wall of Schlemm'"'"'s canal to keep Schlemm'"'"'s canal open.

2. The ocular implant of claim 1, wherein the maximum wave length of the wave-shaped segments of said thin rod is about 5 mm or less.

3. The ocular implant of claim 1, wherein the maximum wave amplitude of the wave-shaped segments is at about 1 mm or less.

4. The ocular implant of claim 1, wherein the minimum tensile strength of the wave-shaped segment is at least about 5 psi.

5. The ocular implant of claim 1, wherein the diameter of said rod is from about 100 to about 200 μ

m.

6. The ocular implant of claim 1, wherein the total length of said thin-rod ranges from about 2 to about 12 mm.

7. The ocular implant of claim 1, wherein said thin-rod is made from a material comprising a shape-memory polymer.

8. The ocular implant of claim 7, wherein said shape-memory polymer is non-wave shaped at room temperature.

9. The ocular implant of claim 8, wherein said shape-memory polymer comprises a plurality of wave-shaped segments when placed within Schlemm'"'"'s canal of an eye.

10. The ocular implant of claim 1, wherein said thin-rod is made from a material comprising a biocompatible polymer, medical grade stainless steel, titanium, nitinol, or plastic, metallic, glass, polyether ether ketone, thermoplastic materials, thermal set materials, photosensitive plastics or acrylic materials.

11. The ocular implant of claim 10, wherein the biocompatible polymer comprises acrylate, methacrylate, or a mixture thereof.

12. A method for reducing intraocular pressure in a subject, said method comprising inserting an ocular implant of claim 1 in Schlemm'"'"'s canal of said subject.

13. The method of claim 12, wherein the ocular implant is implanted using device comprising a cannula or an injection device.

14. The method of claim 12, wherein said method reduces at least 1 mmHg of intraocular pressure.

15. The method of claim 12, wherein intraocular pressure is reduced by at least 10%.

16. A method for treating glaucoma in a subject, said method comprising inserting an ocular implant of claim 1 in Schlemm'"'"'s canal of the subject in need of such a treatment.