SYSTEM AND METHOD FOR IDENTIFYING DISEASE-INFLUENCING GENES
First Claim
1. A method for generating groups of individuals useful in researching influence of a disease on said individuals, comprising:
- selecting individuals having a risk factor for a disease;
providing to each individual a communications apparatus;
transmitting a computer program containing queries and predefined response choices to said communications apparatus, wherein said computer program when executed causes said communications apparatus to present said queries and predefined response choices to each individual via a touch sensitive display of said communications apparatus and collect responses to said queries, including at least one of the predefined response choices presented on the display of the communications apparatus, from each individual via said touch sensitive display of the communications apparatus;
receiving said responses to the queries from the individuals through the apparatus, said responses communicating information about the individuals;
storing the responses of each individual in a database;
defining a plurality of groups by categorizing the individuals having similar profiles based on the responses, wherein categorizing the individuals into groups includes one or more phenotypic classifications;
after defining said groups, receiving genotype information representative of individuals in each of said groups;
comparing said genotype information between said groups; and
generating a report for presentation on a display that represents a subset of said genotype information associated with each of said groups, wherein differences in said genotype information between said groups is expressed in terms of phenotypic classifications.
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Abstract
A system and method for using individuals'"'"' behavioral and environmental information in conjunction with their gene sequences to find drug candidates and drug targets. Individuals designated as having a high risk for developing a particular disease are each given a remotely programmable apparatus. Queries related to the individuals'"'"' behavior and environment are sent from a server to the remotely programmable apparatuses. The individuals'"'"' responses to the queries and any physiological information are sent back to the server. The process of collecting individuals'"'"' information can take place over a period of time to ensure accurate data and to allow researchers to observe progression of the disease. A data mining program on the server analyzes the individuals'"'"' behavioral and environmental information, as well as their gene sequences.
7 Citations
17 Claims
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1. A method for generating groups of individuals useful in researching influence of a disease on said individuals, comprising:
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selecting individuals having a risk factor for a disease; providing to each individual a communications apparatus; transmitting a computer program containing queries and predefined response choices to said communications apparatus, wherein said computer program when executed causes said communications apparatus to present said queries and predefined response choices to each individual via a touch sensitive display of said communications apparatus and collect responses to said queries, including at least one of the predefined response choices presented on the display of the communications apparatus, from each individual via said touch sensitive display of the communications apparatus; receiving said responses to the queries from the individuals through the apparatus, said responses communicating information about the individuals; storing the responses of each individual in a database; defining a plurality of groups by categorizing the individuals having similar profiles based on the responses, wherein categorizing the individuals into groups includes one or more phenotypic classifications; after defining said groups, receiving genotype information representative of individuals in each of said groups; comparing said genotype information between said groups; and generating a report for presentation on a display that represents a subset of said genotype information associated with each of said groups, wherein differences in said genotype information between said groups is expressed in terms of phenotypic classifications. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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9. A system for generating groups of individuals useful in researching influence of a disease on said individuals, comprising:
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a communications apparatus operable by an individual; and a communication network in signal communication with the communications apparatus and a server, a workstation configured to send scripted queries and predefined response choices, a genotyping system configured to provide genotype information representative of the individual, and a patient profile system configured to receive responses from the individual and genotype information analyses via the communications network and the server, wherein the server transmits a computer program containing the scripted queries and predefined response choices to the communications apparatus, the computer program when executed causes the communications apparatus to present the scripted queries and predefined response choices to the individual via a touch sensitive display of said communications apparatus and collect responses to the queries containing information about the individual and at least one of the predefined response choices presented on the touch sensitive display of said communications apparatus, wherein the genotype information is compared based upon groups formed by categorizing individuals having a risk factor for a disease using the responses to the scripted queries in the patient profile system to identify one or more individuals having similar profiles, wherein categorizing the individuals into groups includes one or more phenotypic classifications, and differences in said genotype information between said groups is expressed in terms of phenotypic classifications. - View Dependent Claims (10, 11, 12)
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13. A system for identifying groups of individuals useful in researching influence of disease on said individuals, comprising:
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at least one communications apparatus in signal communication with a monitoring device configured to measure physiologic and environmental conditions, the communications apparatus and monitoring device being operable by at least one individual; and a communication network in signal communications with each communications apparatus and a server, a workstation configured to send scripted queries and predefined response choices, a genotyping system configured to provide genotype information representative of the at least one individual, and a patient profile system configured to receive responses and measurements from the at least one individual and genotype information analyses via the communications network and the server, wherein the server transmits a computer program containing the scripted queries and predefined response choices to the communication apparatus, the computer program when executed causes the communication apparatus to present the scripted queries and predefined response choices to the individual via a touch sensitive display of the communications apparatus and collect responses to the queries containing information about the individual and at least one of the predefined response choices presented on the touch sensitive display of said communications apparatus, wherein the genotype information representative of the at least one individual is compared based upon groups formed by categorizing individuals having a risk factor for a disease using the responses and measurements to the scripted queries in the patient profile system to identify one or more individuals having similar profiles, wherein categorizing the individuals into groups includes one or more phenotypic classifications, and differences in said genotype information between said groups is expressed in terms of phenotypic classifications. - View Dependent Claims (14, 15, 16, 17)
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Specification