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ORALLY EFFECTIVE METHYLPHENIDATE EXTENDED RELEASE POWDER AND AQUEOUS SUSPENSION PRODUCT

  • US 20120207824A1
  • Filed: 09/26/2011
  • Published: 08/16/2012
  • Est. Priority Date: 02/15/2011
  • Status: Active Grant
First Claim
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1. A methylphenidate aqueous extended release oral suspension comprising at least 50% by weight water based on the total weight of the liquid component of the suspension, said suspension consisting of a combination of (a) a sustained release, cured, water-permeable, water-insoluble, non-ionic, polymeric diffusion barrier coated methylphenidate-ion exchange resin complex-matrix, wherein the barrier coating comprises polyvinylacetate and a plasticizer, (b) an immediate release methylphenidate component, (c) water, and (d) pharmaceutically acceptable excipients,said suspension having a pH of about 3.5 to about 5, and said suspension providing a therapeutically effective plasma profile of methylphenidate for about 12 hours.

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