METHOD OF LOCATING AN INGESTED CAPSULE

• US 20120209083A1
• Filed: 12/14/2011
• Published: 08/16/2012
• Est. Priority Date: 09/08/2006
• Status: Abandoned Application

• Current Assignee: Given Imaging Incorporated (Medtronic Plc)
• Original Assignee: The Smart Pill Corporation
• Inventors: Semler, John R.
• Application Number:
  US13/326,045
• Publication Number:
  US 20120209083A1
• Time in Patent Office: Days
• US Class Current: 600/301
• CPC Class Codes: A61B 5/036 by means introduced into body tracts A61B5/032 and A61B5/035 take precedence
• CPC Class Codes: A61B 5/06 Devices, other than using radiation, for detecting or locating foreign bodies for removing same A61B17/50 ; determining position of probes within or on the body of the patient
• CPC Class Codes: A61B 5/14539 for measuring pH
• CPC Class Codes: A61B 5/42 Detecting, measuring or recording for evaluating the gastrointestinal, the endocrine or the exocrine systems A61B1/00, A61B5/4857, A61B5/486, A61B5/4866, A61B5/4869 take precedence

Abstract

A method of determining the location of an ingested capsule comprising the steps of providing an ingestible capsule having a pH sensor and a pressure sensor, having a subject ingest the capsule, recording pH measurements from the pH sensor as a function of time as the capsule moves through at least a portion of the gastrointestinal tract of the subject, recording pressure measurements from the pressure sensor as a function of time as the capsule moves through at least a portion of the gastrointestinal tract of the subject, deriving a frequency of contractions pressure pattern as a function of time and the pressure measurements, and identifying an appreciable variation in the frequency pressure pattern in substantially the same time period as an appreciable variation in the pH to determine the capsule'"'"'s location at a first position in the gastrointestinal tract of the subject.

Claims

1. A method of determining movement of an ingested capsule from a first segment of a gastrointestinal tract to a second segment of said gastrointestinal tract comprising the steps of:

providing an ingestible capsule having a pH sensor and a pressure sensor;

having a subject ingest said capsule;

recording pH measurements from said pH sensor as a function of time as said capsule moves through at least a portion of said gastrointestinal tract of said subject;

recording pressure measurements from said pressure sensor as a function of time as said capsule moves through at least a portion of said gastrointestinal tract of said subject;

deriving a frequency of contraction pressure pattern as a function of time and said pressure measurements; and

identifying an appreciable variation in said frequency pressure pattern in substantially the same time period as an appreciable variation in said pH to determine said capsule'"'"'s location at a first position between the ileum and the caecum of said gastrointestinal tract of said subject.

2. The method set forth in claim 1, wherein said step of identifying an appreciable variation in said frequency pressure pattern in substantially the same time period as an appreciable variation in said measured pH comprises the steps of:

providing a reference pH and a reference frequency pressure pattern; and

analyzing said pH variations for said subject and said frequency pressure pattern variations for said subject relative to said respective references.

3. The method set forth in claim 1, wherein said frequency pressure pattern comprises frequency of contractions relative to a baseline over a given time interval.

4. The method set forth in claim 1, wherein said appreciable variation in said frequency pressure pattern is identified by an algorithm.

5. The method set forth in claim 1, and further comprising the step of identifying a second appreciable variation in said frequency pressure pattern in substantially the same time period as a second appreciable variation in said measured pH to determine said capsule'"'"'s location at a second position between the stomach and the small bowel of said gastrointestinal tract of said subject.

6. The method set forth in claim 5, and further comprising the step of determining transit time between said first position and said second position.

7. A method of determining movement of an ingested capsule from a first segment of a gastrointestinal tract to a second segment of said gastrointestinal tract comprising the steps of:

providing an ingestible capsule having a pH sensor and a pressure sensor;

having a subject ingest said capsule;

recording pH measurements from said pH sensor as a function of time as said capsule moves through at least a portion of the gastrointestinal tract of said subject;

recording pressure measurements from said pressure sensor as a function of time as said capsule moves through at least a portion of said gastrointestinal tract of said subject;

deriving a frequency of contraction pressure pattern as a function of time and said pressure measurements;

identifying an appreciable variation in said pH and frequency pressure pattern to determine said capsule'"'"'s location at a first position; and

identifying an appreciable variation in said pH and frequency pressure pattern to determine said capsule'"'"'s location at a second position.

8. The method set forth in claim 7, wherein said step of identifying an appreciable variation in said frequency pressure pattern comprises the steps of:

providing a reference frequency pressure pattern; and

analyzing said frequency pressure pattern variations for said subject relative to said reference.

9. The method set forth in claim 7, wherein said step of identifying an appreciable variation in said pH comprises the steps of:

providing a reference pH; and

analyzing said pH variations for said subject relative to said reference.

10. The method set forth in claim 9, wherein said reference pH is a sustained pH change that exceeds about 3.

11. The method set forth in claim 7, wherein said frequency pressure pattern comprises frequency of contractions relative to a baseline over a given time interval.

12. The method set forth in claim 7, wherein said appreciable variation in said frequency pressure pattern and said appreciable variation in said pH is identified by an algorithm.

13. The method set forth in claim 7, and further comprising the step of determining transit time between said first position and said second position.

14. The method set forth in claim 7, wherein said first location is a junction between the stomach and the small bowel of said gastrointestinal tract of said subject and said second location is a junction between the ileum and the caecum of said gastrointestinal tract of said subject.

15. A method of determining movement of an ingested capsule from a first segment of a gastrointestinal tract to a second segment of said gastrointestinal tract comprising the steps of:

providing an ingestible capsule having a pH sensor and a pressure sensor;

having a subject ingest said capsule;

recording pH measurements from said pH sensor as a function of time as said capsule moves through at least a portion of said gastrointestinal tract of said subject;

recording pressure measurements from said pressure sensor as a function of time as said capsule moves through at least a portion of said gastrointestinal tract of said subject;

deriving a frequency of contractions pressure pattern as a function of time and said pressure measurements;

providing a reference pH and a reference frequency pressure pattern;

analyzing said pH variations for said subject and said frequency pressure pattern variations for said subject relative to said respective references to determine said capsule'"'"'s location at a first position.

16. The method set forth in claim 15, wherein said frequency pressure pattern comprises frequency of contractions relative to a baseline over a given time interval.

17. The method set forth in claim 15, and further comprising the steps of analyzing said pH variations for said subject and said pressure pattern variations for said subject relative to said respective references to determine said capsule'"'"'s location at a second position.

18. The method set forth in claim 17, and further comprising the step of determining transit time between said first position and said second position.

19. The method set forth in claim 17, wherein said first location is a junction between the stomach and the small bowel of said gastrointestinal tract of said subject and said second location is a junction between the ileum and the caecum of said gastrointestinal tract of said subject.