Apparatus and Methods for Cleaning Reagent Dispensing Tips of a Screening Unit

• US 20120211026A1
• Filed: 10/29/2010
• Published: 08/23/2012
• Est. Priority Date: 10/30/2009
• Status: Abandoned Application

• Current Assignee: Douglas Scientific LLC
• Original Assignee: Douglas Scientific LLC
• Inventors: Schoeneck, Richard Jerome
• Application Number:
  US13/504,537
• Publication Number:
  US 20120211026A1
• Time in Patent Office: Days
• US Class Current: 134/10
• CPC Class Codes: B01L 13/02 for receptacle or instruments
• CPC Class Codes: B01L 2300/0681 Filter
• CPC Class Codes: B01L 2400/049 vacuum
• CPC Class Codes: B01L 3/02 Burettes; Pipettes
• CPC Class Codes: B01L 3/021 Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids
• CPC Class Codes: G01N 35/1004 Cleaning sample transfer devices
• CPC Class Codes: G01N 35/1065 Multiple transfer devices

Abstract

A plurality of reagent dispensing tips (15) are inserted through frustoconical openings (28) in a cover (16) of a cleaning chamber in the form of intersecting axial bores (14) and sprayed with wash fluid from spray passages (34) in the peripheral wall (20) of the cover (16). Wash fluid from the spray passages (34) and flowing through the reagent dispensing tips (15), if hollow, can be drained from the cleaning chamber through a drain port (42). Air is drawn through the frustoconical openings (28) around the reagent dispensing tips (15) into the cleaning chamber, through filter element (64) and from a waste chamber (50) by a vacuum source (78) to remove wash fluid from and otherwise dry the reagent dispensing tips (15).

Claims

1. Method comprising:

inserting a reagent dispensing tip into a cleaning chamber;

spraying wash fluid on the reagent dispensing tip while inserted in the cleaning chamber; and

moving a gas through the cleaning chamber after spraying wash fluid.

2. The method of claim 1 wherein inserting the reagent dispensing tip comprises inserting the reagent dispensing tip into a restricted opening into the cleaning chamber;

and wherein moving the gas comprises supplying a vacuum to draw the gas through the restricted opening and around the reagent dispensing tip.

3. The method of claim 2 wherein supplying the vacuum comprises supplying the vacuum to a waste chamber in fluid communication with the cleaning chamber, with moving the gas including passing the gas through a filter element in the waste chamber.

4. The method of claim 1 wherein moving the gas comprises moving air through the cleaning chamber.

5. The method of claim 1 further comprising:

draining wash fluid from the cleaning chamber before moving the gas through the cleaning chamber.

6. The method of claim 1 wherein spraying wash fluid comprises spraying wash fluid through a spray passage into the cleaning chamber and moving the reagent dispensing tip in a direction parallel to the reagent dispensing tip and relative to the spray passage when spraying wash fluid through the spray passage.

7. The method of claim 1 wherein inserting the reagent dispensing tip comprises inserting a hollow reagent dispensing tip into the cleaning chamber;

and wherein the method further comprises;

flowing wash fluid through the reagent dispensing tip while inserted in the cleaning chamber.

8. The method of claim 1 wherein spraying wash fluid comprises spraying wash fluid to follow a downward spiral path in the cleaning chamber having a cylindrical configuration concentric to the reagent dispensing tip.

9. The method of claim 1 wherein inserting the reagent dispensing tip comprises inserting a plurality of reagent dispensing tips arranged in a plane in a spaced, parallel relation into the cleaning chamber in a form of a plurality of intersecting axial bores.

10. The method of claim 9 wherein inserting the plurality of reagent dispensing tips comprises inserting the plurality of reagent dispensing tips arranged in an array including at least one row and at least one column.

11. Apparatus comprising, in combination:

a cleaning chamber;

a reagent dispensing tip moveable relative to the cleaning chamber, with the cleaning chamber including a spray passage spraying wash fluid on the reagent dispensing tip moving relative to the cleaning chamber; and

a pressure differential source moving a gas through the cleaning chamber and around the reagent dispensing tip.

12. The apparatus of claim 11 with the reagent dispensing tip moveable relative to the cleaning chamber in a movement direction parallel to the reagent dispensing tip, with the spray passage being aligned with the movement direction.

13. The apparatus of claim 11 wherein the pressure differential source comprises a vacuum source in fluid communication with the cleaning chamber and wherein the apparatus further comprises, in combination:

a waste chamber in fluid communication with the cleaning chamber; and

a filter element received in the waste chamber, with the filter element being in fluid communication intermediate the cleaning chamber and the vacuum source.

15. The apparatus of claim 11 wherein wash fluid is dispensed through the reagent dispensing tip into the cleaning chamber.

16. The apparatus of claim 11 further comprising, in combination:

a closeable drain plug in a bottom of the cleaning chamber.

17. The apparatus of claim 11 wherein the cleaning chamber is an axial bore having a cylindrical configuration concentric to the reagent dispensing tip.

18. The apparatus of claim 17 wherein the cleaning chamber includes a cover having a peripheral wall corresponding to and for slideable receipt into the axial bore and a top integrally connected to an upper edge of the peripheral wall, with the top including a restricted opening for receipt of the reagent dispensing tip, with the spray passage formed in the peripheral wall.

19. The apparatus of claim 18 further comprising, in combination:

first and second seals on an outer surface of the peripheral wall and in sealing engagement with the axial bore; and

a channel formed on the outer surface of the peripheral wall, with the spray passage in fluid communication with the channel, wherein the restricted opening is a frustoconical opening of decreasing size toward the spray passage.

21. The apparatus of claim 11 further comprising, in combination:

a plurality of reagent dispensing tips arranged in a plane in a spaced, parallel relation with the reagent dispensing tip, with the cleaning chamber being in a form of plurality of intersecting axial bores.

22. The apparatus of claim 21 wherein the plurality of reagent dispensing tips are arranged in an array including at least one row and at least one column.

14. (canceled)

20. (canceled)