IMPLANTABLE SYSTEMS AND METHODS FOR USE THEREWITH FOR MONITORING AND MODIFYING ARTERIAL BLOOD PRESSURE WITHOUT REQUIRING AN INTRAVASCULAR PRESSURE TRANSDUCER

• US 20120215275A1
• Filed: 02/23/2011
• Published: 08/23/2012
• Est. Priority Date: 02/23/2011
• Status: Active Grant

• Current Assignee: Pacesetter Incorporated (Abbott Laboratories Incorporated)
• Original Assignee: Pacesetter Incorporated (Abbott Laboratories Incorporated)
• Inventors: Wenzel, Brian Jeffrey, Benser, Michael E., Farazi, Taraneh Ghaffari, Fayram, Timothy A., Karst, Edward, Keel, Allen, Hou, Wenbo, Gill, Jong
• Granted Patent: US 8,478,403 B2
• Time in Patent Office: Days
• US Class Current: 607/19
• CPC Class Codes: A61B 5/0031 Implanted circuitry
• CPC Class Codes: A61B 5/02125 of pulse wave propagation time
• CPC Class Codes: A61B 5/02158 provided with two or more sensor elements
• CPC Class Codes: A61B 5/02416 using photoplethysmograph signals, e.g. generated by infrared radiation A61B5/14552 takes precedence
• CPC Class Codes: A61B 5/283 Invasive
• CPC Class Codes: A61B 5/349 Detecting specific parameters of the electrocardiograph cycle
• CPC Class Codes: A61N 1/36507 controlled by gradient or slope of the heart potential
• CPC Class Codes: A61N 1/36564 controlled by blood pressure
• CPC Class Codes: A61N 1/36585 controlled by two or more physical parameters

Abstract

Embodiments of the present invention are directed to implantable systems, and methods for use therewith, that monitor and modify a patient'"'"'s arterial blood pressure without requiring an intravascular pressure transducer. In accordance with an embodiment, for each of a plurality of periods of time, there is a determination one or more metrics indicative of pulse arrival time (PAT), each of which are indicative of how long it takes for the left ventricle to generate a pressure pulsation that travels from the patient'"'"'s aorta to a location remote from the patient'"'"'s aorta. Based on the one or more metrics indicative of PAT, the patient'"'"'s arterial blood pressure is estimated. Changes in the arterial blood pressure are monitored over time. Additionally, the patient'"'"'s arterial blood pressure can be modified by initiating and/or adjusting pacing and/or other therapy based on the estimates of the patient'"'"'s arterial blood pressure and/or monitored changes therein.

Claims

1. For use with an implantable system, a method for monitoring and modifying a patient'"'"'s arterial blood pressure without requiring an intravascular pressure transducer, the method comprising:

(a) for each of a plurality of periods of time per day during which the patient'"'"'s heart is being paced,

(a.1) obtaining a signal indicative of electrical activity of the patient'"'"'s heart, and a signal indicative of changes in arterial blood volume remote from the patient'"'"'s heart;

(a.2) detecting one or more predetermined features of the signal indicative of electrical activity of the patient'"'"'s heart, and one or more predetermined features of the signal indicative of changes in arterial blood volume remote from the patient'"'"'s heart;

(a.3) determining one or more metrics indicative of pulse arrival time (PAT), each metric indicative of PAT determined by determining a time from one of the detected features of the signal indicative of electrical activity of the patient'"'"'s heart to one of the detected features of the signal indicative of changes in arterial blood volume remote from the patient'"'"'s heart; and

(a.4) estimating the patient'"'"'s arterial blood pressure based on at least one of the one or more metrics indicative of PAT;

(b) monitoring changes in the patient'"'"'s arterial blood pressure based on the estimates of the patient'"'"'s arterial blood pressure; and

(c) modifying the patient'"'"'s arterial blood pressure by adjusting at least one pacing parameter and/or pacing configuration based on the monitored changes in the patient'"'"'s arterial blood pressure.

2. The method of claim 1, wherein at step (c) the modifying the patient'"'"'s arterial blood pressure comprises, performing one or more of the following:

(c.1) adjusting a pacing rate;

(c.2i) adjusting an atrio-ventricular (AV) interval; and

(c.3) adjusting a number of pacing site within the left ventricular chamber; and

(c.4) adjusting one or more pacing site locations within the left ventricular chamber.

3. The method of claim 1, wherein:

step (b) includes monitoring a circadian variability of the patient'"'"'s arterial blood pressure; and

step (c) includes

(c.1) adjusting at least one pacing parameter and/or pacing configuration to increase the circadian variability if the circadian variability is below a first threshold; and

(c.2) adjusting at least one pacing parameter and/or pacing configuration to decrease the circadian variability if the circadian variability is above a second threshold.

4. The method of claim 1, wherein:

step (b) includes monitoring a circadian variability pattern of the patient'"'"'s arterial blood pressure; and

step (c) includes adjusting at least one pacing parameter and/or pacing configuration to cause the circadian variability pattern of the patient'"'"'s arterial blood pressure to track a predetermined circadian variability pattern.

5. The method of claim 1, wherein:

step (a) also includes monitoring changes in the patient'"'"'s activity level; and

step (c) includes adjusting at least one pacing parameter and/or pacing configuration based on the monitored changes in the patient'"'"'s arterial blood pressure and based on the monitored changes in the patient'"'"'s activity level.

6. The method of claim 5, wherein step (c) includes at least one of the following:

(c.1) adjusting at least one pacing parameter and/or pacing configuration to increase the patient'"'"'s arterial blood pressure if an increase in the patient'"'"'s arterial blood pressure is too low for the detected change in the patient'"'"'s activity level; and

(c.2) adjusting at least one pacing parameter and/or pacing configuration to decrease the patient'"'"'s arterial blood pressure if the patient'"'"'s arterial blood pressure is too high for the detected change in the patient'"'"'s activity level.

7. The method of claim 1, wherein:

step (a) also includes monitoring changes in the patient'"'"'s body position; and

step (c) includes adjusting at least one pacing parameter and/or pacing configuration based on the monitored changes in the patient'"'"'s arterial blood pressure and based on the monitored changes in the patient'"'"'s body position.

8. The method of claim 7, wherein:

step (c) includes adjusting at least one pacing parameter and/or pacing configuration to increase the patient'"'"'s arterial blood pressure when a change from a supine body position to a vertical body position is detected.

9. The method of claim 7, wherein step (c) includes at least one of the following:

(c.1) adjusting at least one pacing parameter and/or pacing configuration to increase the patient'"'"'s arterial blood pressure if the change in the patient'"'"'s arterial blood pressure is too low for the detected change in the patient'"'"'s body position; and

(c.2) adjusting at least one pacing parameter and/or pacing configuration to decrease the patient'"'"'s arterial blood pressure if the change in the patient'"'"'s arterial blood pressure is too high for the detected change in the patient'"'"'s body position.

10. The method of claim 1, further comprising tracking cardiovascular risk based on the monitored changes in the patient'"'"'s arterial blood pressure.

11. The method of claim 1, further comprising tracking disease progression based on the monitored changes in the patient'"'"'s arterial blood pressure.

12. An implantable system configured to monitor and modify a patient'"'"'s arterial blood pressure without an intravascular pressure transducer, the system comprising:

one or more pulse generator configured to pace the patient'"'"'s heart;

one or more sensing circuit configured to obtaining a signal indicative of electrical activity of the patient'"'"'s heart;

a plethysmography sensor configured to obtain a signal indicative of changes in arterial blood volume remote from the patient'"'"'s heart;

a monitor configured to, for each of a plurality of periods of time per day during which the patient'"'"'s heart is being paced,

detect one or more predetermined features of the signal indicative of electrical activity of the patient'"'"'s heart;

detect one or more predetermined features of the signal indicative of changes in arterial blood volume remote from the patient'"'"'s heart;

determine one or more metrics indicative of pulse arrival time (PAT) by determining a time from at least one of the detected features of the signal indicative of electrical activity of the patient'"'"'s heart to at least one of the detected features of the signal indicative of changes in arterial blood volume remote from the patient'"'"'s heart; and

estimate the patient'"'"'s arterial blood pressure based on at least one of the one or more metrics indicative of PAT;

wherein the monitor is also configured to monitor changes in the patient'"'"'s arterial blood pressure based on the estimates of the patient'"'"'s arterial blood pressure; and

a controller configured to modify the patient'"'"'s arterial blood pressure by adjusting at least one pacing parameter and/or pacing configuration based on the monitored changes in the patient'"'"'s arterial blood pressure.

13. The implantable system of claim 12, wherein:

the controller is configured to modify arterial blood pressure by adjusting a pacing rate, adjusting an atrio-ventricular (AV) interval, adjusting a number of pacing sites within the left ventricular chamber, and adjusting one or more pacing site locations within the left ventricular chamber.

14. The implantable system of claim 12, wherein:

the monitor is configured to monitor a circadian variability of the patient'"'"'s arterial blood pressure; and

the controller is configured to

adjust at least one pacing parameter and/or pacing configuration to increase the circadian variability if the circadian variability is below a first threshold; and

adjust at least one pacing parameter and/or pacing configuration to decrease the circadian variability if the circadian variability is above a second threshold.

15. The implantable system of claim 12, wherein:

the monitor is configured to monitor a circadian variability pattern of the patient'"'"'s arterial blood pressure; and

the controller is configured to adjust at least one pacing parameter and/or pacing configuration to cause the circadian variability pattern of the patient'"'"'s arterial blood pressure to track a predetermined circadian variability pattern.

16. The implantable system of claim 12, further comprising:

an activity sensor configured to detect changes in the patient'"'"'s activity level;

wherein the monitor is configured to

adjust at least one pacing parameter and/or pacing configuration to increase the patient'"'"'s arterial blood pressure if an increase in the patient'"'"'s arterial blood pressure is too low for the detected change in the patient'"'"'s activity level; and

adjust at least one pacing parameter and/or pacing configuration to decrease the patient'"'"'s arterial blood pressure if the patient'"'"'s arterial blood pressure is too high for the detected change in the patient'"'"'s activity level.

17. The implantable system of claim 12, further comprising:

a posture sensor configured to monitor changes in the patient'"'"'s body position;

wherein the controller is configured to

adjust at least one pacing parameter and/or pacing configuration to increase the patient'"'"'s arterial blood pressure if the change in the patient'"'"'s arterial blood pressure is too low for the detected change in the patient'"'"'s body position; and

adjust at least one pacing parameter and/or pacing configuration to decrease the patient'"'"'s arterial blood pressure if the change in the patient'"'"'s arterial blood pressure is too high for the detected change in the patient'"'"'s body position.

18. The implantable system of claim 12, wherein the monitor is also configured to track cardiovascular risk and/or disease progression based on the monitored changes in the patient'"'"'s arterial blood pressure.

19. For use with an implantable system, a method for monitoring and modifying a patient'"'"'s arterial blood pressure without requiring an intravascular pressure transducer, the method comprising:

(a) for each of a plurality of periods of time

(a.1) determining one or more metrics indicative of pulse arrival time (PAT), each of which are indicative of how long it takes a pulse wave to travel from the patient'"'"'s aorta to a location remote from the patient'"'"'s aorta; and

(a.2) estimating the patient'"'"'s arterial blood pressure based on at least one of the one or more metrics indicative of PAT;

(b) modifying the patient'"'"'s arterial blood pressure by initiating and/or adjusting pacing and/or other therapy based on the estimates of the patient'"'"'s arterial blood pressure and/or changes therein.

20. An implantable system configured to monitor and modify a patient'"'"'s arterial blood pressure without an intravascular pressure transducer, the system comprising:

one or more sensing circuit configured to obtaining a signal indicative of electrical activity of the patient'"'"'s heart;

a plethysmography sensor configured to obtain a signal indicative of changes in arterial blood volume remote from the patient'"'"'s heart;

a monitor configured to, for each of a plurality of periods of time,

determine one or more metrics indicative of pulse arrival time (PAT), each of which are indicative of how long it takes a pulse wave to travel from the patient'"'"'s aorta to a location remote from the patient'"'"'s aorta; and

estimate the patient'"'"'s arterial blood pressure based on at least one of the one or more metrics indicative of PAT;

a controller configured to modify the patient'"'"'s arterial blood pressure by initiating and/or adjusting pacing and/or other therapy based on the estimates of the patient'"'"'s arterial blood pressure and/or changes therein.