COATED BIOLOGICAL MATERIAL HAVING IMPROVED PROPERTIES
First Claim
Patent Images
1. A coated biological material for the manufacture of heart valve prostheses, characterized in that the surface of the biological material is covered entirely or partially with a coating comprising a biocompatible anorganic material.
1 Assignment
0 Petitions
Accused Products
Abstract
Some embodiments of the present invention relate to coated biological material for the manufacture of heart valve prostheses, characterized in that the surface of the biological material is covered entirely or partially with a coating which contains or is composed of a biocompatible anorganic material, and to a process for manufacturing such a coated biological material.
-
Citations
20 Claims
- 1. A coated biological material for the manufacture of heart valve prostheses, characterized in that the surface of the biological material is covered entirely or partially with a coating comprising a biocompatible anorganic material.
- 9. A process for manufacturing a coated biological material comprising the steps of using pulsed laser deposition (PLD) to deposit a coating on at least a portion of the biological material, the coating comprising a biocompatible anorganic material.
-
20. A process for manufacturing a valve cusp of a heart valve prosthesis comprising the steps of:
-
providing a valve cusp made of a biologic material comprising a decellulariced extracellular matrix; operating pulsed laser deposition (PLD) at a frequency of 1 Hz to 300 Hz, a pulse duration of 0.1 ns to 200 ns and an energy density of 0.1 J/cm2 to 30 J/cm2 to coat the surface of the valve cusp with a coating layer having a thickness of between about 100 nm to 3 μ
m, the layer consisting entirely of a biocompatible anorganic material that comprises amorphous carbon having one of an sp2 hybridization portion of 30% to 70% and an sp3 hybridization portion of 70% to 30%; and
,wherein any imunogenic components of the valve cusp are thereby insulated from exposure to the surrounding environment by the biocompatible anorganic coating.
-
Specification