BIVALENT, BISPECIFIC ANTIBODIES
First Claim
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1. An isolated nucleic acid encoding the heavy chain of an antibody wherein the VH domain of said heavy chain is replaced by the VL domain of the corresponding light chain of said antibody.
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Abstract
The present invention relates to nucleic acids which encode the heavy chains and light chains of a novel domain exchanged, bivalent, bispecific antibody, and vectors comprising the same.
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Citations
36 Claims
- 1. An isolated nucleic acid encoding the heavy chain of an antibody wherein the VH domain of said heavy chain is replaced by the VL domain of the corresponding light chain of said antibody.
- 4. An isolated nucleic acid encoding the light chain of an antibody wherein the VL domain of said light chain is replaced by the VH domain of the corresponding heavy chain of said antibody.
- 18. An isolated nucleic acid encoding the heavy chain of an anti-angiopoietin-2 antibody wherein the constant heavy chain domain CH3 is altered or replaced by the CH1 domain of said heavy chain or the CL domain of the light chain for said antibody.
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24. A bivalent, bispecific antibody, comprising:
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a) the light chain and heavy chain of an antibody specifically binding to a first antigen; and b) the light chain and heavy chain of an antibody specifically binding to a second antigen, wherein the variable domains VL and VH from the antibody specifically binding to a second antigen are replaced by each other. - View Dependent Claims (25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36)
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Specification