PERFLUOROCARBON GEL FORMULATIONS

• US 20120225102A1
• Filed: 04/16/2012
• Published: 09/06/2012
• Est. Priority Date: 11/25/2008
• Status: Abandoned Application

• Current Assignee: Oxygen Biotherapeutics, Inc.
• Original Assignee: Oxygen Biotherapeutics, Inc.
• Inventors: Klein, Gerald, Kiral, Richard, Stern, Chris J.
• Application Number:
  US13/447,874
• Publication Number:
  US 20120225102A1
• Time in Patent Office: Days
• US Class Current: 424/400
• CPC Class Codes: A61K 9/0014 Skin, i.e. galenical aspects of topical compositions non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00
• CPC Class Codes: A61K 9/0034 Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
• CPC Class Codes: A61K 9/06 Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels composition of ointments, creams or gels A61K47/00
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61P 17/02 for treating wounds, ulcers, burns, scars, keloids, or the like
• CPC Class Codes: A61P 17/10 Anti-acne agents
• CPC Class Codes: A61P 31/04 Antibacterial agents
• CPC Class Codes: Y02A 50/30 Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

A perfluorocarbon gel composition is disclosed with numerous uses including topical medical and cosmetic uses.

Claims

1-36. -36. (canceled)

37. A method of treating acne in a subject suffering therefrom comprising topically administering to the skin of the subject a composition comprising a perfluorocarbon effective to treat the subject'"'"'s acne.

39. The method of claim 37, wherein the perfluorocarbon is perfluoro(tert-butylcyclohexane).

41. The method of claim 37, wherein the perfluorocarbon is an oxygenated perfluorocarbon.

42. New) The method of claim 37, wherein the composition is a pharmaceutical composition and comprises a pharmaceutically acceptable carrier, or wherein the composition is a cosmetic composition and comprises a cosmetically acceptable carrier.

43. The method of claim 37, wherein the composition a perflurocarbon emulsion, liquid, lotion, ointment, cream, gel, pomade, shampoo or conditioner or foam.

44. The method of claim 41, wherein the perfluorocarbon emulsion has a particle size of about 0.3 microns or less.

45. The method of claim 42, wherein the perfluorocarbon emulsion has a particle size of about 0.05 to 0.1 microns.

46. The method of claim 41, wherein the perfluorocarbon emulsion is an egg yolk phospholipid emulsion buffered in an sotonic medium.

47. The method of any claim 37, wherein the temperature of the composition administered is 10°

C.-30.0°

C.

48. The method of claim 37, wherein the composition is administered at 0.1°

C. to 20.0°

C. below the subject'"'"'s body temperature.

49. The method of claim 37, wherein the subject is human.

50. The method of claim 37, further comprising administering a topical retinoid to the subject.

51. The method of claim 37, further comprising administering a topical antibiotic or systemic antibiotic to the subject.

52. The method of claim 37, further comprising topically administering an anti-inflammatory agent to the subject.

53. The method of claim 37, further comprising administer ng a. topical retinoid, benzoyl peroxide, azelaic acid, a peroxide, tretinoin, or isotretinoin to the subject.

54. The method of claim 37, wherein the subject has skin comedones, pustules or papules which are ameliorated by the method.

55. The method of claim 37, wherein the composition comprises H₂O₂.

38. A method of reducing acne-scarring in a subject suffering from acne vulgaris, treating a Propionibacterium acnes infection of a skin follicle of a subject, reducing proliferation of Propionibacterium acnes in the dermis of a subject, preventing acne in a subject susceptible therefrom, or killing Propionibacterium acnes located on or in the skin of a subject comprising topically administering to the skin of the subject a composition comprising a perfluorocarbon effective to reduce acne-scarring in the subject, treat the Propionibacterium acnes infection of the skin follicle of the subject, reduce proliferation of Propionibacterium acnes in the dermis of the subject, prevent acne in the subject, or kill Propionibacterium acnes located on or in the skin of the subject.

40. The method of claim 38, wherein the perfluorocarbon is perfluoro(tert-butylcyclohexane).

56. A method of increasing oxygen tension in skin of a subject comprising topically administering to the skin of the subject a composition comprising a perfluorocarbon effective to increase the oxygen tension in the skin of the subject, wherein the oxygen tension is increased in a follicle of the skin of the subject.