Method and Composition for Improved Anabolism

• US 20120225139A1
• Filed: 05/01/2012
• Published: 09/06/2012
• Est. Priority Date: 11/09/2009
• Status: Active Grant

• Current Assignee: Glanbia Performance Nutrition Ltd.
• Original Assignee: Bio-Engineered Supplements & Nutrition Incorporated (Glanbia Company-Operative Society Limited)
• Inventors: Ferguson, Chris, Abraham, Sal
• Granted Patent: US 8,491,943 B2
• Time in Patent Office: Days
• US Class Current: 424/728
• CPC Class Codes: A23L 33/10 using additives addition of substantially indigestible substances A23L33/21
• CPC Class Codes: A23L 33/105 Plant extracts, their artificial duplicates or their derivatives
• CPC Class Codes: A23L 33/17 Amino acids, peptides or proteins
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 36/00 Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines antigens from pollen A61K39/36
• CPC Class Codes: A61K 36/296 Epimedium
• CPC Class Codes: A61P 21/06 Anabolic agents androgens A61P5/26

Abstract

Nutritional compositions are provided containing at least one PPAR agonist, at least one PGC-1alpha agonist, and at least one creatine derivative. Methods of promoting anabolism and improving or enhancing physical performance using the compositions are provided. The compositions and methods can be combined with physical training or exercise.

Claims

1-24. -24. (canceled)

25. A nutritional composition comprising:

an amount of Epimedium sagittatum and phytanic acid effective to increase PPAR-alpha activity;

an amount of at least one PGC-1alpha agonist effective to increase PGC-1 alpha activity;

at least one creatine compound selected from the group consisting of creatine, creatine heptyl ester, creatine ethyl ester, creatinol-O-Phosphate, a salt thereof, and combinations thereof; and

a nutraceutically acceptable carrier,

wherein the nutritional composition stimulates anabolism in an individual.

26. The nutritional composition of claim 25, further comprising at least one additional PPAR-alpha agonist selected from one or more of the group consisting of Epimedium grandiflorum, sodium pyruvate, and combinations thereof.

27. The nutritional composition of claim 25, wherein the at least one PGC-1alpha agonist is selected from the group consisting of Epimedium sagittatum, Epimedium grandiflorum, sodium pyruvate, piceatannol, Rhodiola rosea, Japanese Knotweed, and combinations thereof.

28. The nutritional composition of claim 26, wherein the at least one additional PPAR-alpha agonist and the at least one PGC-1alpha agonist are the same component.

29. The nutritional composition of claim 25, further including at least one of a component selected from the group consisting of heptanol, heptaminol, L-lyxoflavin, Oxytropis muricata, hydroxyphenethylamine, N-benzoyl-2-hydroxyphenethylamine, N-nicotinoyl-2-hydroxyphenethylamine, Echeveria glauca, Rhodiola rosea, Panax gingseng, alpha-hydroxyisovaleric acid, alpha-hydroxyisocaproic acid, alpha-hydroxy-beta-methyl valeric acid, alpha-hydroxy-gamma-methylthiobutyric acid, alpha-hydroxy-beta-phenylpropionic acid, alpha-hydroxy-beta-imidazolepropionic acid, alpha-hydroxy-beta-hydroxybutyric acid, alpha-hydroxy-gamma-aminocaproic acid, alpha-hydroxy-gamma-guanidinovaleric acid, kamferol-3,7-dirhamnoside, Shilajit moomiyo extract, Kudzu, Hawthorn, Loquat leaf extract, and mixtures thereof.

34. A method for enhancing physical performance or recovery, the method comprising administering to the subject an effective amount of a nutritional composition according to claim 25.

35. The method of claim 34, wherein the effective amount of the nutritional composition is a daily dose from about 1 gram to about 100 grams.

36. The method of claim 34, further comprising administering the nutritional composition before, during, or after exercise.

37. The method of claim 34, wherein said method increases total work output.

38. The method of claim 34, wherein said method increases muscle growth.

30. A nutritional composition comprising:

an amount of at least one PPAR agonist effective to increase PPAR-alpha activity;

an amount of Rhodiola rosea effective to increase PGC-1alpha activity;

at least one creatine compound selected from the group consisting of creatine, creatine heptyl ester, creatine ethyl ester, creatinol-O-Phosphate, a salt thereof, and combinations thereof; and

a nutraceutically acceptable carrier,

wherein the nutritional composition stimulates anabolism in an individual.

31. The nutritional composition of claim 30, wherein the at least one PPAR agonist is selected from one or more of the group consisting of Epimedium sagittatum, Epimedium grandiflorum, phytanic acid, sodium pyruvate, and combinations thereof.

32. The nutritional composition of claim 30, further comprising at least one additional PGC-1alpha agonist selected from the group consisting of Epimedium sagittatum, Epimedium grandiflorum, sodium pyruvate, piceatannol, Rhodiola rosea, Japanese Knotweed, and combinations thereof.

33. The nutritional composition of claim 30, further comprising at least one of a component selected from the group consisting of heptanol, heptaminol, L-lyxoflavin, Oxytropis muricata, hydroxyphenethylamine, N-benzoyl-2-hydroxyphenethylamine, N-nicotinoyl-2-hydroxyphenethylamine, Echeveria glauca, Panax gingseng, alpha-hydroxyisovaleric acid, alpha-hydroxyisocaproic acid, alpha-hydroxy-beta-methyl valeric acid, alpha-hydroxy-gamma-methylthiobutyric acid, alpha-hydroxy-beta-phenylpropionic acid, alpha-hydroxy-beta-imidazolepropionic acid, alpha-hydroxy-beta-hydroxybutyric acid, alpha-hydroxy-gamma-aminocaproic acid, alpha-hydroxy-gamma-guanidinovaleric acid, kamferol-3,7-dirhamnoside, Shilajit moomiyo extract, Kudzu, Hawthorn, Loquat leaf extract, and mixtures thereof.