SYSTEMS, METHODS, AND DEVICES HAVING STRETCHABLE INTEGRATED CIRCUITRY FOR SENSING AND DELIVERING THERAPY
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Accused Products
Abstract
System, devices and methods are presented that integrate stretchable or flexible circuitry, including arrays of active devices for enhanced sensing, diagnostic, and therapeutic capabilities. The invention enables conformal sensing contact with tissues of interest, such as the inner wall of a lumen, a the brain, or the surface of the heart. Such direct, conformal contact increases accuracy of measurement and delivery of therapy. Further, the invention enables the incorporation of both sensing and therapeutic devices on the same substrate allowing for faster treatment of diseased tissue and fewer devices to perform the same procedure.
124 Citations
38 Claims
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2. An apparatus for detecting and measuring aspects of a tissue of a subject'"'"'s body, comprising:
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a. a stretchable substrate; b. stretchable circuitry disposed on said substrate, said circuitry comprising; (i) a first array of sensing devices comprising contact sensors to generate data indicating that one or more sensors of said first array of sensing devices is in contact with said tissue and to generate data indicative of an area of said contact, (ii) a second array of sensing devices to detect data indicative of a parameter of said tissue; and c. a processing facility in electronic communication with said circuitry, wherein the processing facility receives data indicative of said area of said contact and activates one or more of said sensing devices in said second array that correspond to said area of said contact.
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34. An apparatus for delivery of a therapeutic agent to tissue in a subject'"'"'s body, the apparatus comprising:
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a stretchable substrate; a stretchable circuit positioned at least in part on said substrate, the circuitry comprising; a first plurality of electrodes coupled to the substrate, the first plurality of electrodes configured to deliver the therapeutic agent; a second plurality of contact sensors coupled to the substrate, the second plurality of contact sensors configured to generate data indicative of contact of a portion of the apparatus with the tissue, and at least one processing device coupled to the first plurality of electrodes configured to deliver the therapeutic agent and the second plurality of contact sensors, the processing device configured to activate one or more electrode in the first plurality of electrodes in response to receipt of a signal from one or more contact sensors indicative of contact of the portion of the apparatus with the tissue. - View Dependent Claims (35, 36)
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37. A method to determine parameters of a tissue comprising the steps of:
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a. placing a device comprising a stretchable array of sensors in contact with said tissue; b. determining a subset of sensors in said array of sensors that are in conformal contact with said tissue; and c. activating one or more sensors in said subset of sensors that are in conformal contact with said tissue.
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38. A method to determine parameters of a tissue comprising the steps of:
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a. placing in contact with said tissue a device comprising a stretchable array of contact sensors and an array of sensors to detect data indicative of a parameter of said tissue; b. using said contact sensors to determine a portion of said device that is in conformal contact with said tissue; and c. activating one or more sensors in said array of sensors to detect data indicative of a parameter of said tissue, wherein said one or more sensors are determined to be in said portion of said device that is in conformal contact with said tissue.
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Specification