Vacuum Ablation Apparatus and Method

• US 20120226271A1
• Filed: 05/16/2012
• Published: 09/06/2012
• Est. Priority Date: 03/25/2005
• Status: Abandoned Application

• Current Assignee: AngioDynamics, Inc.
• Original Assignee: AngioDynamics, Inc.
• Inventors: Callas, Peter, Pearson, Robert M.
• Application Number:
  US13/472,557
• Publication Number:
  US 20120226271A1
• Time in Patent Office: Days
• US Class Current: 606/33
• CPC Class Codes: A61B 18/148 having a short, rigid shaft for accessing the inner body transcutaneously, e.g. for neurosurgery or arthroscopy
• CPC Class Codes: A61B 2018/00291 using suction
• CPC Class Codes: A61B 2018/00333 Breast
• CPC Class Codes: A61B 2018/143 multiple needles
• CPC Class Codes: A61B 2018/1475 Electrodes retractable in or deployable from a housing

Abstract

Ablation devices and associated methods are provided for use in ablating a target tissue, such as a cystic lesion. The ablation apparatus includes an integral or connected elongate probe and a deployable structure that is axially slidable along the outer surface of the electrode. The electrode can be disposed at the probe'"'"'s distal end region for ablating tissue when the electrode(s) are activated to create an ablated margin of tissue at least partially surrounding the target tissue. Suction can be applied with a vacuum source operably connected to the proximal end region of the deployable structure. A target tissue, such as a cystic lesion, can be drawn against the surface of the electrical probe.

Claims

1. A method for electrically ablating a target tissue, comprising:

positioning a probe assembly in or near the target tissue to be ablated, wherein the probe assembly comprises a probe having a proximal end, a distal end, and an outer surface; and

a deployable structure having an inner surface, wherein at least a portion of the deployable structure surrounds at least a portion of the outer surface of the probe;

positioning the deployable structure near the target tissue;

applying suction to at least a portion of the probe assembly; and

applying electrical energy to the probe to electrically ablate the tissue.

2. The method of claim 1, wherein the method further comprises axially adjusting the deployable structure along the outer surface of the probe before positioning the deployable structure, wherein the deployable structure is one or more of a shield, a barrier, a skirt, a suction cup, and a cone.

3. The method of claim 1, wherein during the step of positioning the deployable structure, the method further comprises positioning at least a portion of the deployable structure against a surface of a patient'"'"'s skin.

4. The method of claim 1, wherein the deployable structure further comprises a plurality of ribs positioned on the inner surface, and a chamber, wherein during the step of applying suction, the suction is applied to the chamber.

5. The method of claim 4, wherein during the step of applying suction to the chamber, the deployable structure transitions from an unbiased state to a biased state, wherein the plurality of ribs surrounds the outer surface of the probe in a contacting relationship.

6. The method of claim 4, further comprising forming an air-tight seal between at least a portion of the deployable structure and a surface of a patient'"'"'s skin during the step of applying suction.

7. The method of claim 1, wherein at least one opening is positioned at the distal end of the probe, and wherein the method further comprises applying suction at the at least one opening of the positioned probe to draw at least a portion of target tissue into contact with the at least one opening of the probe.

8. The method of claim 7, wherein at least one deployable electrode is aligned with the at least one opening, and wherein during the step of applying suction, at least a portion of target tissue is drawn into contact with the at least one electrode.

9. The method of claim 1, wherein the method further comprises stabilizing the deployable structure and the probe relative to the target tissue during the step of applying suction.

10. The method of claim 1, wherein the target tissue comprises one or more of a cyst, cancerous tissue, uterine fibroids, a tumor with a necrotic core, a polyp, a lesion, a vessel, a duct, an aneurysm, and a body cavity.

11. The method of claim 10, wherein the method further comprises removing at least a portion of the target tissue through suction, wherein the target tissue comprises a liquid.

12. The method of claim 1, further comprising applying electrical pulses to the probe in an amount which is sufficient to induce irreversible electroporation of cells of the target tissue tissue, but which is insufficient to induce thermal damage to substantially all of the target tissue such that the identified tissue cells are killed by irreversible electroporation.

13. The method of claim 1, further comprising applying electrical energy as one or more of radiofrequency energy and microwave energy.

14. The method of claim 1, further comprising infusing at least one agent into the target tissue before, during, or after the step of applying suction, or any combination thereof, wherein the agent is selected from the group comprising:

saline, D5W, and a hypo-tonic solution.

15. The method of claim 1, wherein the method further comprises before applying suction, applying electrical energy to ablate at least a portion of the target tissue.

16. The method of claim 14, wherein the method further comprises applying electrical energy in the form of a sufficient number of electrical pulses to irreversibly electroporate the target tissue.

17. The method of claim 14, wherein the method further comprises applying electrical energy as one or more of radiofrequency energy and microwave energy.

18. The method of claim 1, wherein the method further comprises during the step of applying electrical energy to the target tissue, maintaining the suction.

19. The method of claim 1, wherein the probe comprises a lumen extending along a longitudinal axis of the probe, and wherein suction is applied through the lumen of the probe.

20. The method of claim 1, wherein the probe comprises a lumen extending along a longitudinal axis of the probe, and wherein before, during, or after the step of applying electrical energy, or any combination thereof, at least one agent is infused into the lumen of the probe, wherein the agent is selected from the group comprising:

saline, D5W, and a hypo-tonic solution.

22. The method of claim 20, further comprising applying electrical pulses to the probe in an amount which is sufficient to induce irreversible electroporation of cells of the target tissue, but which is insufficient to induce thermal damage to substantially all of the target tissue such that the identified tissue cells are killed by irreversible electroporation.

23. The method of claim 20, wherein the method further comprises before the step of applying suction, applying electrical energy to the electrodes to electrically ablate the target tissue.

24. The method of claim 20, wherein the target tissue comprises one or more of a cyst, cancerous tissue, uterine fibroids, a tumor with a necrotic core, a polyp, a lesion, a vessel, a duct, an aneurysm, and a body cavity.

25. The method of claim 23, wherein the method further comprises collapsing the aneurysm in or near the aneurysm during the step of applying electrical energy to the at least one electrode.

26. The method of claim 20, further comprising infusing at least one agent into the target tissue before, during, or after the step of applying suction, or any combination thereof, wherein the agent is selected from the group comprising:

saline, D5W, an iso-tonic solution, a hypo-tonic solution, and a hyper-tonic solution.

27. The method of claim 20, wherein during the step of applying electrical energy, suction is maintained.

28. The method of claim 20, wherein the method further comprises stabilizing the target tissue in relationship to the probe during the step of applying suction to the target tissue.

29. The method of claim 20, wherein the probe comprises a lumen extending along a longitudinal axis of the probe, and wherein suction is applied through the lumen of the probe.

30. The method of claim 20, wherein the probe comprises a lumen, and wherein before, during, or after the step of applying electrical energy, or any combination thereof, at least one agent is infused into the lumen of the probe, wherein the agent is selected from the group comprising:

saline, D5W, an iso-tonic solution, a hypo-tonic solution, and a hyper-tonic solution.

21. A method for electrically ablating a target tissue, comprising:

positioning a probe in or near a tissue to be ablated, wherein the probe comprises a proximal end and a distal end, wherein at least one opening is positioned at the distal end of the probe, and wherein at least one electrode is aligned with the at least one opening;

applying suction at the at least one opening of the positioned probe to draw at least a portion of the tissue to be ablated into contact with the at least one opening of the probe; and

applying electrical energy through the at least one electrode to electrically ablate the tissue.

31. The method of claim 21, wherein the method further comprises removing at least a portion of the target tissue through suction, wherein the target tissue comprises a liquid.

32. A probe assembly comprising a probe having a proximal end, a distal end, an outer surface, and a tissue contacting surface, wherein the tissue contacting surface comprises a deployable structure, wherein at least a portion of the deployable structure surrounds at least a portion of the outer surface of the probe, wherein the deployable structure is configured to be fixed to the outer surface of the probe and the tissue.