Method and System for Treatment of a Body of a Mammal in Cardiac Arrest

• US 20120226337A1
• Filed: 03/03/2011
• Published: 09/06/2012
• Est. Priority Date: 03/03/2011
• Status: Active Grant

• Current Assignee: Inserm (institut national de la sant et de la recherche mdicale
• Original Assignee: Inserm (institut national de la sant et de la recherche mdicale
• Inventors: Tissier, Renaud, Berdeaux, Alain
• Granted Patent: US 9,439,804 B2
• Time in Patent Office: Days
• US Class Current: 607/105
• CPC Class Codes: A61F 2007/0063 for cooling
• CPC Class Codes: A61F 2007/0069 with return means
• CPC Class Codes: A61F 7/12 Devices for heating or cooling internal body cavities

Abstract

Method for treatment of a body of a mammal in cardiac arrest, comprising the step of performing a therapeutic hypothermia of the body after the cardiac arrest has occurred, said therapeutic hypothermia comprising:

• • cooling the body to a target temperature during a cooling time period, said cooling being performed by total liquid ventilation which comprises alternately filling lungs of the body with a cooling liquid and removing from the lungs said cooling liquid,
  • maintaining the body at the target temperature for a hypothermia duration.

Claims

1. Method for treatment of a body of a mammal in cardiac arrest, comprising the step of performing a therapeutic hypothermia of the body after the cardiac arrest has occurred, said therapeutic hypothermia comprising:

cooling the body to a target temperature during a cooling time period, said cooling being performed by total liquid ventilation which comprises alternately filling lungs of the body with a cooling liquid and removing from the lungs said cooling liquid,

maintaining the body at the target temperature for a hypothermia duration.

2. Method for treatment according to claim 1, further comprising the step of attempting resuscitation of the mammal after the cardiac arrest has occurred.

3. Method for treatment according to claim 2, wherein the therapeutic hypothermia is begun after the step of attempting resuscitation.

4. Method for treatment according to claim 2, wherein the therapeutic hypothermia is begun during the step of attempting resuscitation.

5. Method for treatment according to claim 2, wherein the therapeutic hypothermia is begun before the step of attempting resuscitation.

6. Method for treatment according to claim 2, wherein the step of attempting resuscitation comprises resumption of spontaneous circulation.

7. Method for treatment according to claim 1, wherein the therapeutic hypothermia further comprises removing the cooling liquid after the cooling time period has elapsed, the maintenance of the body at the target temperature being performed by conventional gas ventilation.

8. Method for treatment according to claim 1, further comprising the step of rewarming the body after the hypothermia duration has elapsed.

9. Method for treatment according to claim 1, wherein the mammal is an adult human.

10. System for treatment of a body of a mammal in cardiac arrest, comprising:

a cooling device adapted to cool the body to a target temperature during a cooling time period, said cooling device being adapted to perform total liquid ventilation and comprising;

a reservoir filled with a cooling liquid,

a pumping arrangement adapted to alternately fill lungs of the body with the cooling liquid and remove from the lungs said cooling liquid,

a temperature maintaining device adapted to maintain the body at the target temperature for a hypothermia duration.

11. System for treatment according to claim 10, wherein the cooling liquid is chosen in the group consisting of perfluorocarbons.

12. System for treatment according to claim 10, further comprising at least one resuscitation apparatus adapted to attempt resuscitation of the mammal.