DRUG ADMINISTRATION CONTROLLER

• US 20120227739A1
• Filed: 05/18/2012
• Published: 09/13/2012
• Est. Priority Date: 01/17/2006
• Status: Active Grant

• Current Assignee: Masimo Corporation
• Original Assignee: Masimo Corporation
• Inventors: Kiani, Massi E.
• Granted Patent: US 9,333,316 B2
• Time in Patent Office: Days
• US Class Current: 128/204.23
• CPC Class Codes: A61M 16/0057 Pumps therefor
• CPC Class Codes: A61M 16/12 by mixing different gases
• CPC Class Codes: A61M 2202/0208 Oxygen
• CPC Class Codes: A61M 2202/0233 Carbon monoxide
• CPC Class Codes: A61M 2202/0241 Anaesthetics; Analgesics
• CPC Class Codes: A61M 2205/18 with alarm
• CPC Class Codes: A61M 2205/3313 used specific wavelengths
• CPC Class Codes: A61M 2205/3375 Acoustical, e.g. ultrasonic, measuring means
• CPC Class Codes: A61M 2205/3561 local, e.g. within room or hospital
• CPC Class Codes: A61M 2205/3592 using telemetric means, e.g. radio or optical transmission
• CPC Class Codes: A61M 2205/502 User interfaces, e.g. screens or keyboards
• CPC Class Codes: A61M 2230/005 Parameter used as control input for the apparatus
• CPC Class Codes: A61M 2230/04 Heartbeat characteristics, e.g. ECG, blood pressure modulation
• CPC Class Codes: A61M 2230/10 Electroencephalographic signals
• CPC Class Codes: A61M 2230/204 partial carbon monoxide pressure (P-CO)
• CPC Class Codes: A61M 2230/205 partial oxygen pressure (P-O2)
• CPC Class Codes: A61M 2230/207 hematocrit
• CPC Class Codes: A61M 2230/30 Blood pressure A61M2230/04 takes precedence
• CPC Class Codes: A61M 2230/42 Rate
• CPC Class Codes: A61M 2230/432 partial CO2 pressure (P-CO2)
• CPC Class Codes: A61M 2230/50 : Temperature
• CPC Class Codes: A61M 5/142 : Pressure infusion, e.g. using pumps
• CPC Class Codes: A61M 5/1723 : using feedback of body parameters, e.g. blood-sugar, pressure measurement of body parameters A61B5/00

Abstract

A drug administration controller has a sensor that generates a sensor signal to a physiological measurement device, which measures a physiological parameter in response. A control output responsive to the physiological parameter or a metric derived from the physiological parameter causes a drug administration device to affect the treatment of a person, such as by initiating, pausing, halting or adjusting the dosage of drugs administered to the person.

Claims

1. A drug administration method comprising:

measuring at least one physiological parameter with a noninvasive optical sensor attached to a patient;

deriving at least one parameter trend for the at least one measured physiological parameter, the trend indicating if the at least one parameter for each measured physiological parameter is increasing or decreasing at a certain rate over a certain time; and

controlling a drug administration device based at least on one of the at least one parameter trends, wherein the at least one physiological parameter is a measure of blood methemoglobin (HbMet).

2. The drug administration method according to claim 1 comprising deriving at least one parameter limit, a parameter pattern and a parameter variability.

3. The drug administration method according to claim 1 wherein controlling comprises pausing the drug administration device when HbMet is trending upward.

4. The drug administration method according to claim 1 wherein controlling comprises pausing the drug administration device when HbMet is above a HbMet limit.

5. A drug administration controller comprising:

at least one noninvasive optical sensor that generates at least one sensor signal in response to a physiological state of a living being;

at least one physiological measurement device that generates measurements of at least one physiological parameter in response to the at least one sensor signal, said at least on physiological parameter including methemoglobin (HbMet);

a rule-based processor that generates a control output in response to at least trends of the physiological parameter measurements, the trends indicating if the physiological parameter measurements are increasing or decreasing at a certain rate over a certain time; and

a drug administration device responsive to one or more control outputs so as to affect the treatment of the living being including at least one of initiating, pausing, halting or adjusting the dosage of administered drugs.

6. The drug administration controller according to claim 5 wherein the drug administration device is one of a drug infusion device and a medical gas inhalation device.

7. The drug administration controller according to claim 5 further comprising a sound sensor attached proximate to a neck site so as to measure respiration rate.

8. A drug administration method comprising:

measuring a physiological parameter in response to a sensor attached to a patient;

deriving a metric corresponding to the physiological parameter; and

controlling a drug administration device based upon the metric, the metric being a number of cyclical desaturations over a given timeframe greater than a predetermined threshold.

9. The drug administration method of claim 8, further comprising measuring the physiological parameter using a pulse oximeter.

10. The drug administration method of claim 8, further comprising controlling the drug administration based upon the metric and a measure of perfusion index.

11. The drug administration method of claim 10, further comprising controlling the drug administration based on a carboxyhemoglobin measurement.

12. A drug administration controller comprising:

at least one sensor that generates at least one sensor signal in response to a physiological state of a living being;

at least one physiological measurement device that generates measurements of at least one physiological parameter in response to the at least one sensor signal;

a processor that generates a control output in response to the physiological parameter measurements, the physiological parameter measurements including a measure of a number of cyclical desaturations over a given timeframe which is greater than a predetermined threshold; and

a drug administration device responsive to one or more control outputs so as to affect the treatment of the living being including at least one of initiating, pausing, halting or adjusting the dosage of administered drugs.

13. The drug administration controller according to claim 12, wherein the drug administration device is one of a drug infusion device and a medical gas inhalation device.

14. The drug administration controller according to claim 13, wherein the at least one sensor comprises:

an optical sensor attached to a tissue site so as to measure at least one blood parameter; and

a sound sensor attached proximate to a neck site so as to measure respiration rate.