METHOD FOR MONITORING ANTICOAGULANT THERAPY
First Claim
1. A method for measuring the activity of an anticoagulant drug in a patient, which is based on measuring in a test plasma sample from said patient combined activity of only coagulation factors II and X, the method comprising:
- mixing said test plasma sample with plasma deficient in only factor II and factor X,adding to said test plasma sample one or more coagulation reagent and calcium, anddetermining blood clotting ability by measuring blood clotting time or thrombin generation.
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Abstract
A method of measuring the combined activity of both and only coagulation factors II and X for the purpose of monitoring anticoagulant therapy, and kits for using the method. The method involves mixing of test plasma from a human to be tested with specially prepared plasma deficient in both and only coagulation factors II and X but with normal levels of other factors (referred to herein as Fiix-deficient plasma or Fiix plasma), in order to correct for any possible deficiency in other coagulation factors than FII and FX in the test sample. By adding a coagulation reagent and calcium, the generation of thrombin or fibrin can be measured. Kits of the invention comprise a coagulation reagent, calcium and specially made plasma that is deficient in both and only factor II and factor FX.
21 Citations
17 Claims
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1. A method for measuring the activity of an anticoagulant drug in a patient, which is based on measuring in a test plasma sample from said patient combined activity of only coagulation factors II and X, the method comprising:
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mixing said test plasma sample with plasma deficient in only factor II and factor X, adding to said test plasma sample one or more coagulation reagent and calcium, and determining blood clotting ability by measuring blood clotting time or thrombin generation. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. A test kit for measuring the activity of an anticoagulant drug in a patient, comprising:
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a coagulation reagent, and normal plasma that is deficient in factor II and factor X and which contains other factors including factor VII and IX (Fiix deficient plasma). - View Dependent Claims (11, 12, 13, 14, 15, 16, 17)
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Specification